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Results: 1 to 20 of 21

1.

The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease.

Karuppagounder SS, Brahmachari S, Lee Y, Dawson VL, Dawson TM, Ko HS.

Sci Rep. 2014 May 2;4:4874. doi: 10.1038/srep04874.

2.

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.

Lee Y, Karuppagounder SS, Shin JH, Lee YI, Ko HS, Swing D, Jiang H, Kang SU, Lee BD, Kang HC, Kim D, Tessarollo L, Dawson VL, Dawson TM.

Nat Neurosci. 2013 Oct;16(10):1392-400. doi: 10.1038/nn.3500. Epub 2013 Aug 25.

3.

Sulfhydration mediates neuroprotective actions of parkin.

Vandiver MS, Paul BD, Xu R, Karuppagounder S, Rao F, Snowman AM, Ko HS, Lee YI, Dawson VL, Dawson TM, Sen N, Snyder SH.

Nat Commun. 2013;4:1626. doi: 10.1038/ncomms2623.

4.

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.

Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14103-8. doi: 10.1073/pnas.1108799108. Epub 2011 Aug 8.

5.

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.

Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, Troconso JC, Dawson VL, Dawson TM.

Cell. 2011 Mar 4;144(5):689-702. doi: 10.1016/j.cell.2011.02.010.

6.

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.

Ko HS, Lee Y, Shin JH, Karuppagounder SS, Gadad BS, Koleske AJ, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16691-6. doi: 10.1073/pnas.1006083107. Epub 2010 Sep 7.

7.

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.

Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM.

Nat Med. 2010 Sep;16(9):998-1000. doi: 10.1038/nm.2199. Epub 2010 Aug 22.

8.

Genetic animal models of Parkinson's disease.

Dawson TM, Ko HS, Dawson VL.

Neuron. 2010 Jun 10;66(5):646-61. doi: 10.1016/j.neuron.2010.04.034. Review.

9.

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.

Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, Magrané J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, Li C, Tieu K, Przedborski S.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):378-83. doi: 10.1073/pnas.0911187107. Epub 2009 Dec 4.

10.

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease.

Tsang AH, Lee YI, Ko HS, Savitt JM, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Chung KK.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4900-5. doi: 10.1073/pnas.0810595106. Epub 2009 Mar 9. Erratum in: Proc Natl Acad Sci U S A. 2009 May 26;106(21):8791.

11.

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.

Ko HS, Bailey R, Smith WW, Liu Z, Shin JH, Lee YI, Zhang YJ, Jiang H, Ross CA, Moore DJ, Patterson C, Petrucelli L, Dawson TM, Dawson VL.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2897-902. doi: 10.1073/pnas.0810123106. Epub 2009 Feb 5.

12.

Role of tuberin in neuronal degeneration.

Habib SL, Michel D, Masliah E, Thomas B, Ko HS, Dawson TM, Abboud H, Clark RA, Imam SZ.

Neurochem Res. 2008 Jun;33(6):1113-6. doi: 10.1007/s11064-007-9558-8. Epub 2008 Mar 5.

13.

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.

Tan JM, Wong ES, Kirkpatrick DS, Pletnikova O, Ko HS, Tay SP, Ho MW, Troncoso J, Gygi SP, Lee MK, Dawson VL, Dawson TM, Lim KL.

Hum Mol Genet. 2008 Feb 1;17(3):431-9. Epub 2007 Nov 1.

14.

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase.

Andres-Mateos E, Perier C, Zhang L, Blanchard-Fillion B, Greco TM, Thomas B, Ko HS, Sasaki M, Ischiropoulos H, Przedborski S, Dawson TM, Dawson VL.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14807-12. Epub 2007 Aug 31.

15.

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations.

Wong ES, Tan JM, Wang C, Zhang Z, Tay SP, Zaiden N, Ko HS, Dawson VL, Dawson TM, Lim KL.

J Biol Chem. 2007 Apr 20;282(16):12310-8. Epub 2007 Feb 28.

16.

Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.

Ko HS, Kim SW, Sriram SR, Dawson VL, Dawson TM.

J Biol Chem. 2006 Jun 16;281(24):16193-6. Epub 2006 May 3.

17.

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.

Wang C, Ko HS, Thomas B, Tsang F, Chew KC, Tay SP, Ho MW, Lim TM, Soong TW, Pletnikova O, Troncoso J, Dawson VL, Dawson TM, Lim KL.

Hum Mol Genet. 2005 Dec 15;14(24):3885-97. Epub 2005 Nov 8.

18.

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

Ko HS, von Coelln R, Sriram SR, Kim SW, Chung KK, Pletnikova O, Troncoso J, Johnson B, Saffary R, Goh EL, Song H, Park BJ, Kim MJ, Kim S, Dawson VL, Dawson TM.

J Neurosci. 2005 Aug 31;25(35):7968-78.

19.

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

Sriram SR, Li X, Ko HS, Chung KK, Wong E, Lim KL, Dawson VL, Dawson TM.

Hum Mol Genet. 2005 Sep 1;14(17):2571-86. Epub 2005 Jul 27.

20.
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