Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1987 1
1988 1
1989 2
1990 1
1992 1
1996 1
1999 1
2000 4
2002 1
2003 4
2004 2
2005 1
2006 2
2007 5
2008 5
2009 3
2010 2
2011 4
2012 2
2013 6
2014 2
2015 2
2016 3
2017 5
2018 2
2019 1
2021 2
2022 2
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

61 results

Results by year

Filters applied: . Clear all
Page 1
Rapid and Sensitive Quantification of Intracellular Glycyl-Sarcosine for Semi-High-Throughput Screening for Inhibitors of PEPT-1.
von Linde T, Bajraktari-Sylejmani G, Haefeli WE, Burhenne J, Weiss J, Sauter M. von Linde T, et al. Pharmaceutics. 2021 Jul 3;13(7):1019. doi: 10.3390/pharmaceutics13071019. Pharmaceutics. 2021. PMID: 34371711 Free PMC article.
Its role in the uptake of small bioactive peptides and various therapeutics makes it an important target for the investigation of the systemic absorption of small peptide-like active compounds and prodrug strategies of poorly absorbed therapeutics. The dipeptide glycyl- …
Its role in the uptake of small bioactive peptides and various therapeutics makes it an important target for the investigation of the system …
In vivo effects of glycyl-glutamate and glycyl-sarcosine on gabapentin oral absorption in rat.
Nguyen TV, Fleisher D, Smith DE. Nguyen TV, et al. Pharm Res. 2007 Aug;24(8):1538-43. doi: 10.1007/s11095-007-9272-x. Epub 2007 Mar 23. Pharm Res. 2007. PMID: 17380260
In agreement, the oral absorption of gabapentin, relative to the intravenous dose, was 79% after glycyl-glutamate loading but only 47% when drug was administered alone. However, when glycyl-sarcosine was added to the orally administered admixture of gabapentin plus …
In agreement, the oral absorption of gabapentin, relative to the intravenous dose, was 79% after glycyl-glutamate loading but only 47% when …
Crystal structure and conformation of glycyl-glycyl-sarcosine.
Subramanian E, Parthasarathy R. Subramanian E, et al. Int J Pept Protein Res. 1989 May;33(5):345-7. doi: 10.1111/j.1399-3011.1989.tb00692.x. Int J Pept Protein Res. 1989. PMID: 2767887
Crystals of the tripeptide, glycyl-glycyl-sarcosine (C7H13N3O4) from aqueous methanol are orthorhombic, space group Pbcn with cell parameters at 294 K of a = 8.279(1), b = 9.229(4), c = 24.447(5)A, V = 1868.0 A3, M.W. = 203.2, and Z = 8. ...
Crystals of the tripeptide, glycyl-glycyl-sarcosine (C7H13N3O4) from aqueous methanol are orthorhombic, space group Pbcn with …
Structural Design of Oligopeptides for Intestinal Transport Model.
Hong SM, Tanaka M, Koyanagi R, Shen W, Matsui T. Hong SM, et al. J Agric Food Chem. 2016 Mar 16;64(10):2072-9. doi: 10.1021/acs.jafc.6b00279. Epub 2016 Mar 4. J Agric Food Chem. 2016. PMID: 26924013
Glycyl-sarcosine (Gly-Sar) is a well-known model substrate for the intestinal uptake of dipeptides through peptide transporter 1 (PepT1). ...
Glycyl-sarcosine (Gly-Sar) is a well-known model substrate for the intestinal uptake of dipeptides through peptide transporter …
Lysine Dipeptide Enhances Gut Structure and Whole-Body Protein Synthesis in Neonatal Piglets with Intestinal Atrophy.
Kirupananthan D, Bertolo RF, Brunton JA. Kirupananthan D, et al. J Nutr. 2022 Aug 9;152(8):1843-1850. doi: 10.1093/jn/nxac095. J Nutr. 2022. PMID: 35481706 Free article.
METHODS: Piglets aged 7-8 days were PN-fed for 4 days to induce intestinal atrophy, then were refed with enteral diets with equimolar lysine supplied as lysyl-lysine (Lys-Lys; n = 7), free lysine (n = 7), or Lys-Lys with glycyl-sarcosine (n = 6; to determine whether …
METHODS: Piglets aged 7-8 days were PN-fed for 4 days to induce intestinal atrophy, then were refed with enteral diets with equimolar lysine …
Functional characterization of oligopeptide transporter 1 of dairy cows.
Xu Q, Liu Z, Liu H, Zhao F, Huang X, Wu Y, Liu J. Xu Q, et al. J Anim Sci Biotechnol. 2018 Jan 23;9:7. doi: 10.1186/s40104-017-0219-8. eCollection 2018. J Anim Sci Biotechnol. 2018. PMID: 29387385 Free PMC article.
Therefore, the purpose of this study was to characterize bPepT1 functionally using a mammalian cell expression system. The uptake of radiolabeled dipeptide glycyl-sarcosine ([(3)H]-Gly-Sar) into the bPepT1-transfected Chinese hamster ovary cells was measured at vari …
Therefore, the purpose of this study was to characterize bPepT1 functionally using a mammalian cell expression system. The uptake of radiola …
Rapid and sensitive hydrophilic interaction chromatography/tandem mass spectrometry method for the determination of glycyl-sarcosine in cell homogenates.
Sun Y, Sun J, Liu J, Yin S, Chen Y, Zhang P, Pu X, Sun Y, He Z. Sun Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 1;877(7):649-52. doi: 10.1016/j.jchromb.2009.01.019. Epub 2009 Jan 21. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19201665
A rapid, selective and sensitive hydrophilic interaction chromatography/tandem mass spectrometry (HILIC/MS/MS) was developed and validated for the determination of glycyl-sarcosine (Gly-Sar) in Caco-2 cell homogenates. After a simple protein precipitation with aceto …
A rapid, selective and sensitive hydrophilic interaction chromatography/tandem mass spectrometry (HILIC/MS/MS) was developed and validated f …
Rat Kidney Slices for Evaluation of Apical Membrane Transporters in Proximal Tubular Cells.
Arakawa H, Kubo H, Washio I, Staub AY, Nedachi S, Ishiguro N, Nakanishi T, Tamai I. Arakawa H, et al. J Pharm Sci. 2019 Aug;108(8):2798-2804. doi: 10.1016/j.xphs.2019.03.031. Epub 2019 Apr 5. J Pharm Sci. 2019. PMID: 30959054
Na(+)-dependent uptake of ergothioneine (Octn1), carnitine (Octn2), and methyl-alpha-D-glucopyranoside (Sglt1/2) by rat kidney slices was observed, and the uptake was decreased by selective inhibitors. In addition, uptake of glycyl-sarcosine (Pept1/2) showed H(+)-de …
Na(+)-dependent uptake of ergothioneine (Octn1), carnitine (Octn2), and methyl-alpha-D-glucopyranoside (Sglt1/2) by rat kidney slices was ob …
Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins.
Lu X, Chan T, Xu C, Zhu L, Zhou QT, Roberts KD, Chan HK, Li J, Zhou F. Lu X, et al. J Antimicrob Chemother. 2016 Feb;71(2):403-12. doi: 10.1093/jac/dkv340. Epub 2015 Oct 22. J Antimicrob Chemother. 2016. PMID: 26494147 Free PMC article.
RESULTS: Colistin and polymyxin B potently inhibited PEPT2-mediated [(3)H]glycyl-sarcosine uptake (IC50 11.4 3.1 and 18.3 4.2 muM, respectively). In contrast, they had no or only mild inhibitory effects on the transport activity of the other 14 SLCs evaluated. MIPS- …
RESULTS: Colistin and polymyxin B potently inhibited PEPT2-mediated [(3)H]glycyl-sarcosine uptake (IC50 11.4 3.1 and 18.3 4.2 …
61 results