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Items: 1 to 20 of 708

1.

Mitochondrial Dysfunction during the Early Stages of Excitotoxic Spinal Motor Neuron Degeneration in Vivo.

Santa-Cruz LD, Guerrero-Castillo S, Uribe-Carvajal S, Tapia R.

ACS Chem Neurosci. 2016 Apr 29. [Epub ahead of print]

PMID:
27090876
2.

[The pathogenesis of amyotrophic lateral sclerosis and frontal lobe dementia is unraveling: pathology of the nucleus and glutamate sensitivity].

Tienari P, Kiviharju A, Valori M, Lindholm D, Laaksovirta H.

Duodecim. 2016;132(5):423-31. Finnish.

PMID:
27089615
3.

The herbal extract KCHO-1 exerts a neuroprotective effect by ameliorating oxidative stress via heme oxygenase-1 upregulation.

Lee DS, Ko W, Song BK, Son I, Kim DW, Kang DG, Lee HS, Oh H, Jang JH, Kim YC, Kim S.

Mol Med Rep. 2016 Apr 14. doi: 10.3892/mmr.2016.5129. [Epub ahead of print]

PMID:
27082826
4.

Metabotropic glutamate receptors in cancer.

Yu LJ, Wall BA, Wangari-Talbot J, Chen S.

Neuropharmacology. 2016 Feb 16. pii: S0028-3908(16)30046-6. doi: 10.1016/j.neuropharm.2016.02.011. [Epub ahead of print] Review.

PMID:
26896755
5.

Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis.

Moujalled D, White AR.

CNS Drugs. 2016 Mar;30(3):227-43. doi: 10.1007/s40263-016-0317-8.

PMID:
26895253
6.

Protective effect of valproic acid on cultured motor neurons under glutamate excitotoxic conditions. Ultrastructural study.

Nagańska E, Matyja E, Taraszewska A, Rafałowska J.

Folia Neuropathol. 2015;53(4):309-16.

PMID:
26785365
7.

Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors.

Siklos M, BenAissa M, Thatcher GR.

Acta Pharm Sin B. 2015 Nov;5(6):506-19. doi: 10.1016/j.apsb.2015.08.001. Epub 2015 Sep 26. Review.

8.

Multifactorial Gene Therapy Enhancing the Glutamate Uptake System and Reducing Oxidative Stress Delays Symptom Onset and Prolongs Survival in the SOD1-G93A ALS Mouse Model.

Benkler C, Barhum Y, Ben-Zur T, Offen D.

J Mol Neurosci. 2016 Jan;58(1):46-58. doi: 10.1007/s12031-015-0695-2. Epub 2015 Dec 21.

PMID:
26691332
9.

Disruption of TCA Cycle and Glutamate Metabolism Identified by Metabolomics in an In Vitro Model of Amyotrophic Lateral Sclerosis.

Veyrat-Durebex C, Corcia P, Piver E, Devos D, Dangoumau A, Gouel F, Vourc'h P, Emond P, Laumonnier F, Nadal-Desbarats L, Gordon PH, Andres CR, Blasco H.

Mol Neurobiol. 2015 Dec 14. [Epub ahead of print]

PMID:
26666663
10.

C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.

O'Rourke JG, Bogdanik L, Muhammad AK, Gendron TF, Kim KJ, Austin A, Cady J, Liu EY, Zarrow J, Grant S, Ho R, Bell S, Carmona S, Simpkinson M, Lall D, Wu K, Daughrity L, Dickson DW, Harms MB, Petrucelli L, Lee EB, Lutz CM, Baloh RH.

Neuron. 2015 Dec 2;88(5):892-901. doi: 10.1016/j.neuron.2015.10.027.

PMID:
26637796
11.

Aberrant association of misfolded SOD1 with Na(+)/K(+)ATPase-α3 impairs its activity and contributes to motor neuron vulnerability in ALS.

Ruegsegger C, Maharjan N, Goswami A, Filézac de L'Etang A, Weis J, Troost D, Heller M, Gut H, Saxena S.

Acta Neuropathol. 2016 Mar;131(3):427-51. doi: 10.1007/s00401-015-1510-4. Epub 2015 Nov 30.

PMID:
26619836
12.

Cognitive impairment in amyotrophic lateral sclerosis, clues from the SOD1 mouse.

Spalloni A, Longone P.

Neurosci Biobehav Rev. 2016 Jan;60:12-25. doi: 10.1016/j.neubiorev.2015.11.006. Epub 2015 Nov 19. Review.

PMID:
26602023
13.

PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene.

Brownell AL, Kuruppu D, Kil KE, Jokivarsi K, Poutiainen P, Zhu A, Maxwell M.

J Neuroinflammation. 2015 Nov 24;12:217. doi: 10.1186/s12974-015-0439-9.

14.

Excitotoxicity in ALS: Overstimulation, or overreaction?

King AE, Woodhouse A, Kirkcaldie MT, Vickers JC.

Exp Neurol. 2016 Jan;275 Pt 1:162-71. doi: 10.1016/j.expneurol.2015.09.019. Epub 2015 Nov 13. Review.

PMID:
26584004
15.

Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis.

Golko-Perez S, Mandel S, Amit T, Kupershmidt L, Youdim MB, Weinreb O.

Neurotox Res. 2016 Feb;29(2):208-17. doi: 10.1007/s12640-015-9574-4. Epub 2015 Nov 18.

PMID:
26581376
16.

Bcl11b: A New Piece to the Complex Puzzle of Amyotrophic Lateral Sclerosis Neuropathogenesis?

Lennon MJ, Jones SP, Lovelace MD, Guillemin GJ, Brew BJ.

Neurotox Res. 2016 Feb;29(2):201-7. doi: 10.1007/s12640-015-9573-5. Epub 2015 Nov 12.

PMID:
26563995
17.

Homocysteine aggravates ROS-induced depression of transmitter release from motor nerve terminals: potential mechanism of peripheral impairment in motor neuron diseases associated with hyperhomocysteinemia.

Bukharaeva E, Shakirzyanova A, Khuzakhmetova V, Sitdikova G, Giniatullin R.

Front Cell Neurosci. 2015 Oct 6;9:391. doi: 10.3389/fncel.2015.00391. eCollection 2015.

18.

Glial TDP-43 regulates axon wrapping, GluRIIA clustering and fly motility by autonomous and non-autonomous mechanisms.

Romano G, Appocher C, Scorzeto M, Klima R, Baralle FE, Megighian A, Feiguin F.

Hum Mol Genet. 2015 Nov 1;24(21):6134-45. doi: 10.1093/hmg/ddv330. Epub 2015 Aug 13.

19.

Investigation of vitamin D receptor polymorphisms in amyotrophic lateral sclerosis.

Török N, Török R, Klivényi P, Engelhardt J, Vécsei L.

Acta Neurol Scand. 2016 Apr;133(4):302-8. doi: 10.1111/ane.12463. Epub 2015 Jul 20.

PMID:
26190642
20.

Neural and glial progenitor transplantation as a neuroprotective strategy for Amyotrophic Lateral Sclerosis (ALS).

Haidet-Phillips AM, Maragakis NJ.

Brain Res. 2015 Dec 2;1628(Pt B):343-50. doi: 10.1016/j.brainres.2015.06.035. Epub 2015 Jul 14. Review.

PMID:
26187754
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