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miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair.

Czochor JR, Sulkowski P, Glazer PM.

Mol Cancer Res. 2016 Apr;14(4):363-73. doi: 10.1158/1541-7786.MCR-15-0399. Epub 2016 Feb 5.


Nanotechnology for delivery of peptide nucleic acids (PNAs).

Gupta A, Bahal R, Gupta M, Glazer PM, Saltzman WM.

J Control Release. 2016 Jan 8. pii: S0168-3659(16)30004-9. doi: 10.1016/j.jconrel.2016.01.005. [Epub ahead of print]


DNA-dependent targeting of cell nuclei by a lupus autoantibody.

Weisbart RH, Chan G, Jordaan G, Noble PW, Liu Y, Glazer PM, Nishimura RN, Hansen JE.

Sci Rep. 2015 Jul 9;5:12022. doi: 10.1038/srep12022.


YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.

Stachelek GC, Peterson-Roth E, Liu Y, Fernandez RJ 3rd, Pike LR, Qian JM, Abriola L, Hoyer D, Hungerford W, Merkel J, Glazer PM.

Mol Cancer Res. 2015 Oct;13(10):1389-97. doi: 10.1158/1541-7786.MCR-15-0036. Epub 2015 Jun 26.


Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment.

Scanlon SE, Glazer PM.

DNA Repair (Amst). 2015 Aug;32:180-9. doi: 10.1016/j.dnarep.2015.04.030. Epub 2015 May 1. Review.


Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium.

McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME.

Nat Commun. 2015 Apr 27;6:6952. doi: 10.1038/ncomms7952.


Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines.

Colis LC, Hegan DC, Kaneko M, Glazer PM, Herzon SB.

J Am Chem Soc. 2015 May 6;137(17):5741-7. doi: 10.1021/ja513117p. Epub 2015 Apr 22.


LKB1 preserves genome integrity by stimulating BRCA1 expression.

Gupta R, Liu AY, Glazer PM, Wajapeyee N.

Nucleic Acids Res. 2015 Jan;43(1):259-71. doi: 10.1093/nar/gku1294. Epub 2014 Dec 8.


MicroRNA silencing for cancer therapy targeted to the tumour microenvironment.

Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ.

Nature. 2015 Feb 5;518(7537):107-10. doi: 10.1038/nature13905. Epub 2014 Nov 17.


Therapeutic genome mutagenesis using synthetic donor DNA and triplex-forming molecules.

Reza F, Glazer PM.

Methods Mol Biol. 2015;1239:39-73. doi: 10.1007/978-1-4939-1862-1_4.


Single-stranded ╬│PNAs for in vivo site-specific genome editing via Watson-Crick recognition.

Bahal R, Quijano E, McNeer NA, Liu Y, Bhunia DC, Lopez-Giraldez F, Fields RJ, Saltzman WM, Ly DH, Glazer PM.

Curr Gene Ther. 2014;14(5):331-42.


Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung.

Fields RJ, Quijano E, McNeer NA, Caputo C, Bahal R, Anandalingam K, Egan ME, Glazer PM, Saltzman WM.

Adv Healthc Mater. 2015 Feb 18;4(3):361-6. doi: 10.1002/adhm.201400355. Epub 2014 Aug 25.


Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1.

Lu Y, Wajapeyee N, Turker MS, Glazer PM.

Cell Rep. 2014 Jul 24;8(2):501-13. doi: 10.1016/j.celrep.2014.06.035. Epub 2014 Jul 17.


Targeted genome modification via triple helix formation.

Ricciardi AS, McNeer NA, Anandalingam KK, Saltzman WM, Glazer PM.

Methods Mol Biol. 2014;1176:89-106. doi: 10.1007/978-1-4939-0992-6_8.


HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutS╬▒.

Zhang M, Xiang S, Joo HY, Wang L, Williams KA, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, Dong H, Shan B, Fang B, Radhakrishnan R, Glazer PM, Matthias P, Koomen J, Seto E, Bepler G, Nicosia SV, Chen J, Li C, Gu L, Li GM, Bai W, Wang H, Zhang X.

Mol Cell. 2014 Jul 3;55(1):31-46. doi: 10.1016/j.molcel.2014.04.028. Epub 2014 May 29.


The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA.

Colis LC, Woo CM, Hegan DC, Li Z, Glazer PM, Herzon SB.

Nat Chem. 2014 Jun;6(6):504-10. doi: 10.1038/nchem.1944. Epub 2014 May 11.


Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.

Scanlon SE, Glazer PM.

Mol Cancer Res. 2014 Jul;12(7):1016-28. doi: 10.1158/1541-7786.MCR-13-0628. Epub 2014 Mar 31.


Triplex-mediated genome targeting and editing.

Reza F, Glazer PM.

Methods Mol Biol. 2014;1114:115-42. doi: 10.1007/978-1-62703-761-7_8.



Sweasy JB, Glazer PM.

Yale J Biol Med. 2013 Dec;86(4):441-2. No abstract available.


Hypoxia and DNA repair.

Glazer PM, Hegan DC, Lu Y, Czochor J, Scanlon SE.

Yale J Biol Med. 2013 Dec 13;86(4):443-51.

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