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Page 1
Analysis of shared heritability in common disorders of the brain.
Brainstorm Consortium; Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinge… See abstract for full author list ➔ Brainstorm Consortium, et al. Science. 2018 Jun 22;360(6395):eaap8757. doi: 10.1126/science.aap8757. Science. 2018. PMID: 29930110 Free PMC article.
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,64 …
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic …
Gilles de la Tourette syndrome.
Robertson MM, Eapen V, Singer HS, Martino D, Scharf JM, Paschou P, Roessner V, Woods DW, Hariz M, Mathews CA, Črnčec R, Leckman JF. Robertson MM, et al. Nat Rev Dis Primers. 2017 Feb 2;3:16097. doi: 10.1038/nrdp.2016.97. Nat Rev Dis Primers. 2017. PMID: 28150698 Review.
Gilles de la Tourette syndrome (GTS) is a childhood-onset neurodevelopmental disorder that is characterized by several motor and phonic tics. ...Management usually includes psychoeducation and reassurance, behavioural methods, pharmacotherapy an …
Gilles de la Tourette syndrome (GTS) is a childhood-onset neurodevelopmental disorder that is characteriz …
Tics and Tourette syndrome.
Efron D, Dale RC. Efron D, et al. J Paediatr Child Health. 2018 Oct;54(10):1148-1153. doi: 10.1111/jpc.14165. J Paediatr Child Health. 2018. PMID: 30294996 Review.
Tourette syndrome is a heterogeneous disorder. The genetic basis is complex, and both in utero and ex utero environmental factors may modify the phenotypic expression of the disorder. ...In this article, the clinical features and pathophysiology of Tourett …
Tourette syndrome is a heterogeneous disorder. The genetic basis is complex, and both in utero and ex utero environment …
Tics.
Pringsheim T, Davenport WJ, Lang A. Pringsheim T, et al. Curr Opin Neurol. 2003 Aug;16(4):523-7. doi: 10.1097/01.wco.0000084232.82329.47. Curr Opin Neurol. 2003. PMID: 12869813 Review.
PURPOSE OF REVIEW: This paper reviews the recent literature concerning Tourette syndrome and related disorders. RECENT FINDINGS: Tourette syndrome is a common disorder in children and adolescents, with an established association with attention deficit …
PURPOSE OF REVIEW: This paper reviews the recent literature concerning Tourette syndrome and related disorders. RECENT FINDING …
Tourette syndrome and obsessive-compulsive disorder: A comprehensive review of structural alterations and neurological mechanisms.
Shitova AD, Zharikova TS, Kovaleva ON, Luchina AM, Aktemirov AS, Olsufieva AV, Sinelnikov MY, Pontes-Silva A, Zharikov YO. Shitova AD, et al. Behav Brain Res. 2023 Sep 13;453:114606. doi: 10.1016/j.bbr.2023.114606. Epub 2023 Jul 30. Behav Brain Res. 2023. PMID: 37524204 Review.
Currently, it is possible to study the pathogenesis of Tourette's syndrome (TS) in more detail, due to more advanced methods of neuroimaging. ...A neurotransmitter deficiency in CSTC has been demonstrated by immunohistochemical and genetic methods, but …
Currently, it is possible to study the pathogenesis of Tourette's syndrome (TS) in more detail, due to more advanced methods o …
A Review and Update on Tourette Syndrome: Where Is the Field Headed?
Gunduz A, Okun MS. Gunduz A, et al. Curr Neurol Neurosci Rep. 2016 Apr;16(4):37. doi: 10.1007/s11910-016-0633-x. Curr Neurol Neurosci Rep. 2016. PMID: 26936259 Review.
Tourette syndrome (TS) is a childhood onset neurologic disorder with manifestations including multiple motor and phonic tics, and in most cases a variety of behavioral comorbidities such as attention deficit hyperactivity disorder, obsessive compulsive disorder, and …
Tourette syndrome (TS) is a childhood onset neurologic disorder with manifestations including multiple motor and phonic tics, …
Recent progress on Tourette syndrome.
Ueda K, Black KJ. Ueda K, et al. Fac Rev. 2021 Sep 7;10:70. doi: 10.12703/r/10-70. eCollection 2021. Fac Rev. 2021. PMID: 34557874 Free PMC article. Review.
Tic disorders and Tourette syndrome are the most common movement disorders in children and are characterized by movements or vocalizations. Clinically, Tourette syndrome is frequently associated with comorbid psychiatric symptoms. ...
Tic disorders and Tourette syndrome are the most common movement disorders in children and are characterized by movements or v …
A personal 35 year perspective on Gilles de la Tourette syndrome: assessment, investigations, and management.
Robertson MM. Robertson MM. Lancet Psychiatry. 2015 Jan;2(1):88-104. doi: 10.1016/S2215-0366(14)00133-3. Epub 2015 Jan 8. Lancet Psychiatry. 2015. PMID: 26359615 Review.
After having examined the definition, clinical phenomenology, comorbidity, psychopathology, and phenotypes in the first paper of this Series, here I discuss the assessment, including neuropsychology, and the effects of Gilles de la Tourette syndrome …
After having examined the definition, clinical phenomenology, comorbidity, psychopathology, and phenotypes in the first paper of this Series …
Tourette's Syndrome.
Shavitt RG, Hounie AG, Rosário Campos MC, Miguel EC. Shavitt RG, et al. Psychiatr Clin North Am. 2006 Jun;29(2):471-86. doi: 10.1016/j.psc.2006.02.005. Psychiatr Clin North Am. 2006. PMID: 16650718 Free article. Review.
One of the main features of tic-related OCD is the frequent presence of sensory phenomena preceding the compulsions, in the absence of obsessions. Genetic epidemiologic studies provide consistent evidence for the association between TS and OCD. ...Genes interact with envir …
One of the main features of tic-related OCD is the frequent presence of sensory phenomena preceding the compulsions, in the absence of obses …
Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development.
Hughes DE, Kunitoki K, Elyounssi S, Luo M, Bazer OM, Hopkinson CE, Dowling KF, Doyle AE, Dunn EC, Eryilmaz H, Gilman JM, Holt DJ, Valera EM, Smoller JW, Cecil CAM, Tiemeier H, Lee PH, Roffman JL. Hughes DE, et al. Nat Neurosci. 2023 Jun;26(6):959-969. doi: 10.1038/s41593-023-01321-8. Epub 2023 May 18. Nat Neurosci. 2023. PMID: 37202553 Free PMC article.
We leveraged polygenic scores (PGSs) to parse genomic risk for childhood symptoms and to uncover related neurodevelopmental mechanisms with transcriptomic and neuroimaging data. In independent samples (Adolescent Brain Cognitive Development, Generation R) a narrow cross-di …
We leveraged polygenic scores (PGSs) to parse genomic risk for childhood symptoms and to uncover related neurodevelopmental mechanisms with …
44 results