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An Insight into the Mechanism of Holamine- and Funtumine-Induced Cell Death in Cancer Cells.
Badmus JA, Ekpo OE, Sharma JR, Sibuyi NRS, Meyer M, Hussein AA, Hiss DC. Badmus JA, et al. Molecules. 2020 Dec 3;25(23):5716. doi: 10.3390/molecules25235716. Molecules. 2020. PMID: 33287388 Free PMC article.
Holamine and funtumine, steroidal alkaloids with strong and diverse pharmacological activities are commonly found in the Apocynaceae family of Holarrhena. ...Both compounds also induced F-actin disorganization and inhibited topoisomerase-I activity. Although holamine and …
Holamine and funtumine, steroidal alkaloids with strong and diverse pharmacological activities are commonly found in the Apocynaceae …
Cytotoxic and cell cycle arrest properties of two steroidal alkaloids isolated from Holarrhena floribunda (G. Don) T. Durand & Schinz leaves.
Badmus JA, Ekpo OE, Hussein AA, Meyer M, Hiss DC. Badmus JA, et al. BMC Complement Altern Med. 2019 May 31;19(1):112. doi: 10.1186/s12906-019-2521-9. BMC Complement Altern Med. 2019. PMID: 31151442 Free PMC article.
RESULTS: Bioassay-guided fractionation yielded two steroidal alkaloids: holamine (1) and funtumine (2). The MTT reduction assay shows that both compounds exhibited selective dose-dependent cytotoxicity against the cancer cell lines studied. ...
RESULTS: Bioassay-guided fractionation yielded two steroidal alkaloids: holamine (1) and funtumine (2). The MTT reduction assay shows …
A new steroid derivative stabilizes g-quadruplexes and induces telomere uncapping in human tumor cells.
Brassart B, Gomez D, De Cian A, Paterski R, Montagnac A, Qui KH, Temime-Smaali N, Trentesaux C, Mergny JL, Gueritte F, Riou JF. Brassart B, et al. Mol Pharmacol. 2007 Sep;72(3):631-40. doi: 10.1124/mol.107.036574. Epub 2007 Jun 22. Mol Pharmacol. 2007. PMID: 17586599
Woodson and is known for its curarizing and DNA-binding properties. Steroid FG, a funtumine derivative substituted with a guanylhydrazone moiety, interacted selectively with the telomeric G-quadruplex in vitro. ...
Woodson and is known for its curarizing and DNA-binding properties. Steroid FG, a funtumine derivative substituted with a guanylhydra …