Figure 3

Representative microscopic findings of skin tissue of mice treated with carrageenan and/or fucoidan or Cistanche tubulosa (CT) extract. A, normal; B, carrageenan alone; C, fucoidan 18 mg/kg; D, fucoidan 54 mg/kg; E, CT extract 54 mg/kg; F, CT extract 162 mg/kg; G, fucoidan 18 mg/kg+CT extract 54 mg/kg; H, fucoidan 54 mg/kg+CT extract 162 mg/kg; I, fucoidan 90 mg/kg+CT extract 270 mg/kg. Bar=200 µm.

Synergistic anti-inflammatory effects of Laminaria japonica fucoidan and Cistanche tubulosa extract

Lab Anim Res. 2012 June;28(2):91-97.
Figure 4Expression of Bcl-2, Bax, Survivin, ERK, cytochrome C, Caspase-3 and VEGF in 4T1 cells after 48 h treatment of fucoidan detected by Western blot.

Expression of the β-actin gene was used as the internal control. Data are mean±SD of one representative experiment performed in triplicate. Fucoidan significantly decreased the expression of Bcl-2, did not modulate the expression of Bax, but the ratio Bcl-2/Bax was decreased. Fucoidan also decreased the protein expression of Survivin and phosphorylated ERKs in 4T1 cells. Fucoidan treatment significantly increased levels of cytochrome C in the cytoplasm, whereas there was a significant corresponding decline of mitochondrial cytochrome C. Cytochrome oxidase (subunit II) was as sample loading control (cyt. oxid). The level of pro-caspase-3 decreased after fucoidan treatment, while the level of caspase-3 cleavage protein increased after fucoidan treatment. Fucoidan decreased VEGF expression in 4T1 cells. Lane 1: control cells; lanes 2–4: 4T1 cells treated with 50, 100 and 200 μg/ml fucoidan respectively. *P<0.05, vs. Control; **P<0.01, vs. Control.

Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo

PLoS One. 2012;7(8):e43483.
Figure 1Effect of fucoidan on the growth of normal mouse fibroblasts.

The effect of fucoidan on the proliferation of normal mouse fibroblasts (L929 cells) was measured by MTT assay. The cells viability of each fucoidan treatment group(50,100 and 200µg/ml) was not statistically significant, compared with that of untreated controls (P>0.05). Data are shown as mean ± S.D. Fucoidan did not affect the viability of normal mouse fibroblasts.

Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo

PLoS One. 2012;7(8):e43483.
Fig. 5

The inhibitory effect of fucoidan on SMC proliferation. The antiproliferative effect of fucoidan on SMC was stronger than that of heparin. Cell proliferation was inhibited at 50 µg/mL of both fucoidan and heparin. Above a concentration of 500 µg/mL, fucoidan showed a stronger antiproliferative effect on SMCs than heparin. ^*P<0.01

Biological effects of fucoidan isolated from Fucus vesiculosus on thrombosis and vascular cells

Korean J Hematol. 2010 March;45(1):51-57.

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Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo. [PLoS One. 2012]
Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo.
Xue M, Ge Y, Zhang J, Wang Q, Hou L, Liu Y, Sun L, Li Q. PLoS One. 2012; 7(8):e43483. Epub 2012 Aug 20.
Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection. [World J Gastroenterol. 2012]
Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection.
Mori N, Nakasone K, Tomimori K, Ishikawa C. World J Gastroenterol. 2012 May 14; 18(18):2225-30.
Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice. [Fitoterapia. 2012]
Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice.
Kim KJ, Yoon KY, Lee BY. Fitoterapia. 2012 Sep; 83(6):1105-9. Epub 2012 May 3.

123 free full-text articles in PubMed Central

Low molecular weight fucoidan against renal ischemia-reperfusion injury via inhibition of the MAPK signaling pathway. [PLoS One. 2013]
Low molecular weight fucoidan against renal ischemia-reperfusion injury via inhibition of the MAPK signaling pathway.
Chen J, Wang W, Zhang Q, Li F, Lei T, Luo D, Zhou H, Yang B. PLoS One. 2013; 8(2):e56224. Epub 2013 Feb 13.
DNA-fragments are transcytosed across CaCo-2 cells by adsorptive endocytosis and vesicular mediated transport. [PLoS One. 2013]
DNA-fragments are transcytosed across CaCo-2 cells by adsorptive endocytosis and vesicular mediated transport.
Johannessen LE, Spilsberg B, Wiik-Nielsen CR, Kristoffersen AB, Holst-Jensen A, Berdal KG. PLoS One. 2013; 8(2):e56671. Epub 2013 Feb 11.
Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. [PLoS One. 2013]
Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism.
Finley A, Chen Z, Esposito E, Cuzzocrea S, Sabbadini R, Salvemini D. PLoS One. 2013; 8(1):e55255. Epub 2013 Jan 25.

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