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Fraxin represses NF-kappaB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis.
Zeng J, Liang L, Chen R, Li C, Pan L, Wen M, Lv D, Liu M, Xu Z, Huang H. Zeng J, et al. Eur J Pharmacol. 2023 Sep 15;955:175915. doi: 10.1016/j.ejphar.2023.175915. Epub 2023 Jul 17. Eur J Pharmacol. 2023. PMID: 37467841
However, the regulatory role of Fraxin on diabetic RIF remains unclear. In this study, we investigated the renal protective benefits of Fraxin against diabetic RIF and elucidated its mechanisms. ...Thus, Fraxin may be a potential drug candidate for treating D …
However, the regulatory role of Fraxin on diabetic RIF remains unclear. In this study, we investigated the renal protective benefits …
Fraxin inhibits lipopolysaccharide-induced inflammatory cytokines and protects against endotoxic shock in mice.
Li W, Li W, Yu J, Liu F, Zang L, Xiao X, Zhao J, Yao Q, Niu X. Li W, et al. Fundam Clin Pharmacol. 2020 Feb;34(1):91-101. doi: 10.1111/fcp.12500. Epub 2019 Aug 28. Fundam Clin Pharmacol. 2020. PMID: 31325387
Fraxin, the effective component isolated from Cortex Fraxini, has been reported to have anti-inflammation effects. ...We used Kunming male mice to establish the model, and we found that fraxin could improve the survival rate of the LPS-induced mice. Histopathologica …
Fraxin, the effective component isolated from Cortex Fraxini, has been reported to have anti-inflammation effects. ...We used Kunming …
Fraxin Prevents Chemically Induced Hepatotoxicity by Reducing Oxidative Stress.
Chang BY, Jung YS, Yoon CS, Oh JS, Hong JH, Kim YC, Kim SY. Chang BY, et al. Molecules. 2017 Apr 6;22(4):587. doi: 10.3390/molecules22040587. Molecules. 2017. PMID: 28383514 Free PMC article.
However, pharmacological activities of fraxin remain to be elucidated. This study investigated the potential hepatoprotective effects of fraxin and the underlying signaling mechanism involved. ...Fraxin protected Hep G2 cells through Nrf2 pathway-dependent HO …
However, pharmacological activities of fraxin remain to be elucidated. This study investigated the potential hepatoprotective effects …
Fraxin inhibits melanogenesis by suppressing the ERK/MAPK pathway and antagonizes oxidative stress by activating the NRF2 pathway.
Luo L, Yu X, Zeng H, Hu Y, Jiang L, Huang J, Fu C, Chen J, Zeng Q. Luo L, et al. Heliyon. 2023 Aug 3;9(8):e18929. doi: 10.1016/j.heliyon.2023.e18929. eCollection 2023 Aug. Heliyon. 2023. PMID: 37600361 Free PMC article.
In this study, we further explored the anti-melanogenic activities of fraxin were explored in vitro and in vivo. We found that pretreatment with fraxin decreased the melanin content of MNT1 cells and zebrafishes. ...Further experimentation revealed that fraxin …
In this study, we further explored the anti-melanogenic activities of fraxin were explored in vitro and in vivo. We found that pretre …
Fraxin in Combination with Dexamethasone Attenuates LPS-Induced Liver and Heart Injury and Their Anticytokine Activity in Mice.
Shaker NS, Sahib HB. Shaker NS, et al. Adv Virol. 2023 Sep 11;2023:5536933. doi: 10.1155/2023/5536933. eCollection 2023. Adv Virol. 2023. PMID: 37727368 Free PMC article.
Therefore, further investigation is warranted into the role of fraxin as an anticytokine storm agent and the involvement of IL-8 in cytokine storms. The present study examines the preventive efficacy of fraxin and the combination of fraxin and dexamethasone ( …
Therefore, further investigation is warranted into the role of fraxin as an anticytokine storm agent and the involvement of IL-8 in c …
Is natural fraxin an overlooked radical scavenger?
Nam PC, Thong NM, Hoa NT, Quang DT, Hoang LP, Mechler A, Vo QV. Nam PC, et al. RSC Adv. 2021 Apr 15;11(24):14269-14275. doi: 10.1039/d1ra01360b. eCollection 2021 Apr 15. RSC Adv. 2021. PMID: 35423974 Free PMC article.
Fraxin (FX) (7-hydroxy-6-methoxycoumarin 8-glucoside) is a typical natural product of the coumarin family. ...
Fraxin (FX) (7-hydroxy-6-methoxycoumarin 8-glucoside) is a typical natural product of the coumarin family. ...
Fraxin Prevents Knee Osteoarthritis through Inhibiting Chondrocyte Apoptosis in an Experimental Rat Osteoarthritis Model.
Qian Z, Ru X, Liu C, Huang X, Sun Q. Qian Z, et al. Protein Pept Lett. 2021;28(11):1298-1302. doi: 10.2174/0929866528666211022152556. Protein Pept Lett. 2021. PMID: 34719360
OBJECTIVE: The objective of this study is to investigate the effect of fraxin on knee OA in a rat model and probe into the possible molecular mechanism. ...Fraxin remarkably down-regulated the expression of cleaved-Caspase-3 while significantly up-regulated the expr …
OBJECTIVE: The objective of this study is to investigate the effect of fraxin on knee OA in a rat model and probe into the possible m …
Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside) confers protection against ionizing radiation-induced intestinal epithelial injury in vitro and in vivo.
Tang FL, Xie LW, Tang LF, Lu HY, Zhu RQ, Wang DF, Tian Y, Cai S, Li M. Tang FL, et al. Int Immunopharmacol. 2024 Mar 10;129:111637. doi: 10.1016/j.intimp.2024.111637. Epub 2024 Feb 8. Int Immunopharmacol. 2024. PMID: 38335653
Several studies have underscored the anti-inflammatory, antibacterial, antioxidant, and immunomodulatory properties of fraxin. However, the efficacy of fraxin at preventing or mitigating RIID remains unclear. ...In summary, fraxin is demonstrated to possess t …
Several studies have underscored the anti-inflammatory, antibacterial, antioxidant, and immunomodulatory properties of fraxin. Howeve …
Fraxin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting the NF-kappaB and NLRP3 signalling pathways.
Li W, Li W, Zang L, Liu F, Yao Q, Zhao J, Zhi W, Niu X. Li W, et al. Int Immunopharmacol. 2019 Feb;67:1-12. doi: 10.1016/j.intimp.2018.12.003. Epub 2018 Dec 6. Int Immunopharmacol. 2019. PMID: 30530164
Fraxin, the effective component of the Chinese traditional medicine Cortex Fraxini, is reported to have anti-inflammatory effects. ...Overall, fraxin played a protective role in LPS-induced lung injury by inhibiting the NF-kappaB and NLRP3 signalling pathways....
Fraxin, the effective component of the Chinese traditional medicine Cortex Fraxini, is reported to have anti-inflammatory effects. .. …
Fraxin Alleviates LPS-Induced ARDS by Downregulating Inflammatory Responses and Oxidative Damages and Reducing Pulmonary Vascular Permeability.
Ma X, Liu X, Feng J, Zhang D, Huang L, Li D, Yin L, Li L, Wang XZ. Ma X, et al. Inflammation. 2019 Oct;42(5):1901-1912. doi: 10.1007/s10753-019-01052-8. Inflammation. 2019. PMID: 31273573
However, the effects of fraxin on ARDS have yet to be reported. In the present study, the protective effect of fraxin in lipopolysaccharide (LPS)-induced ARDS in a mouse model was analyzed. ...Fraxin might increase the superoxide dismutase (SOD) activity to a …
However, the effects of fraxin on ARDS have yet to be reported. In the present study, the protective effect of fraxin in lipop …
79 results