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1984 1
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19 results

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Page 1
Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3).
Fanidi A, Muller DC, Yuan JM, Stevens VL, Weinstein SJ, Albanes D, Prentice R, Thomsen CA, Pettinger M, Cai Q, Blot WJ, Wu J, Arslan AA, Zeleniuch-Jacquotte A, McCullough ML, Le Marchand L, Wilkens LR, Haiman CA, Zhang X, Han J, Stampfer MJ, Smith-Warner SA, Giovannucci E, Giles GG, Hodge AM, Severi G, Johansson M, Grankvist K, Langhammer A, Krokstad S, Næss M, Wang R, Gao YT, Butler LM, Koh WP, Shu XO, Xiang YB, Li H, Zheng W, Lan Q, Visvanathan K, Bolton JH, Ueland PM, Midttun Ø, Ulvik A, Caporaso NE, Purdue M, Ziegler RG, Freedman ND, Buring JE, Lee IM, Sesso HD, Gaziano JM, Manjer J, Ericson U, Relton C, Brennan P, Johansson M. Fanidi A, et al. J Natl Cancer Inst. 2018 Jan 1;110(1):57-67. doi: 10.1093/jnci/djx119. J Natl Cancer Inst. 2018. PMID: 28922778 Free PMC article.
The association between these biomarkers and lung cancer risk was evaluated using conditional logistic regression models. ...We further noted that the association of folate was restricted to Europe/Australia and Asia, whereas no clear association was observed for the Unite …
The association between these biomarkers and lung cancer risk was evaluated using conditional logistic regression models. ...We furth …
Serum folate concentration and the incidence of lung cancer.
Durda K, Kąklewski K, Gupta S, Szydłowski M, Baszuk P, Jaworska-Bieniek K, Sukiennicki G, Kaczmarek K, Waloszczyk P, Narod S, Lubiński J, Jakubowska A. Durda K, et al. PLoS One. 2017 May 11;12(5):e0177441. doi: 10.1371/journal.pone.0177441. eCollection 2017. PLoS One. 2017. PMID: 28493936 Free PMC article.
BACKGROUND: Lung cancer is a leading cause of cancer-related mortality globally. ...The odds ratio for lung cancer declined with increasing serum content of the folate. ...
BACKGROUND: Lung cancer is a leading cause of cancer-related mortality globally. ...The odds ratio for lung cancer declined wi …
Genetic, epigenetic and genomic mechanisms of methionine dependency of cancer and tumor-initiating cells: What could we learn from folate and methionine cycles.
Guéant JL, Oussalah A, Zgheib R, Siblini Y, Hsu SB, Namour F. Guéant JL, et al. Biochimie. 2020 Jun;173:123-128. doi: 10.1016/j.biochi.2020.03.015. Epub 2020 Apr 11. Biochimie. 2020. PMID: 32289469 Review.
It is related to an increased demand for methionine and SAM, which is not compensated by the increased production of formate by glycine decarboxylase pathway in lung cancer tumor spheres. Tumor spheres of glioblastoma U251 are methionine-dependent through dis …
It is related to an increased demand for methionine and SAM, which is not compensated by the increased production of formate by glyci …
Correlation of toxicities and efficacies of pemetrexed with clinical factors and single-nucleotide polymorphisms: a prospective observational study.
Takeda Y, Naka G, Katsuya Y, Kobayashi K, Suzuki M, Hashimoto M, Hirano S, Uemura Y. Takeda Y, et al. BMC Cancer. 2023 Aug 26;23(1):800. doi: 10.1186/s12885-023-11257-8. BMC Cancer. 2023. PMID: 37633908 Free PMC article.
BACKGROUND: Pemetrexed is an efficacious multi-targeted antifolate with acceptable toxicity for non-squamous non-small cell lung cancer (non-Sq NSCLC) and malignant pleural mesothelioma. Vitamin B12 and folic acid as premedication can reduce the freque …
BACKGROUND: Pemetrexed is an efficacious multi-targeted antifolate with acceptable toxicity for non-squamous non-small cell lung canc …
Methyl-Donors Can Induce Apoptosis and Attenuate Both the Akt and the Erk1/2 Mediated Proliferation Pathways in Breast and Lung Cancer Cell Lines.
Kiss E, Forika G, Mohacsi R, Nemeth Z, Krenacs T, Dank M. Kiss E, et al. Int J Mol Sci. 2021 Mar 30;22(7):3598. doi: 10.3390/ijms22073598. Int J Mol Sci. 2021. PMID: 33808426 Free PMC article.
Therefore, we investigated the proposed cancer inhibitory effects of methyl-donors (in a mixture of L-methionine, choline chloride, folic acid, and vitamin B12) on MCF7 and T47D breast cancer as well as A549 and H1650 lung cancer cell lines. ...Therefo …
Therefore, we investigated the proposed cancer inhibitory effects of methyl-donors (in a mixture of L-methionine, choline chloride, …
Association of Three Single Nucleotide Polymorphisms in MTR and MTRR Genes with Lung Cancer in a Turkish Population.
Aksoy-Sagirli P, Erdenay A, Kaytan-Saglam E, Kizir A. Aksoy-Sagirli P, et al. Genet Test Mol Biomarkers. 2017 Jul;21(7):428-432. doi: 10.1089/gtmb.2017.0062. Epub 2017 May 24. Genet Test Mol Biomarkers. 2017. PMID: 28537809
Polymorphisms in folate metabolism may affect enzyme activities and thereby affect the cancer risk. Methionine synthase (MTR) and methionine synthase reductase (MTRR) are critical enzymes for the folate cycle. In this study, possible associations between genetic var …
Polymorphisms in folate metabolism may affect enzyme activities and thereby affect the cancer risk. Methionine synthase (MTR) and …
Dietary intake of selected B vitamins in relation to risk of major cancers in women.
Kabat GC, Miller AB, Jain M, Rohan TE. Kabat GC, et al. Br J Cancer. 2008 Sep 2;99(5):816-21. doi: 10.1038/sj.bjc.6604540. Epub 2008 Jul 29. Br J Cancer. 2008. PMID: 18665162 Free PMC article. Clinical Trial.
Although folic acid has been investigated for its potential to inhibit carcinogenesis, few epidemiologic studies have assessed the effects of intake of thiamin, riboflavin, and niacin, which may reduce cancer risk by acting as cofactors in folate metabolism or by ot …
Although folic acid has been investigated for its potential to inhibit carcinogenesis, few epidemiologic studies have assessed …
Metabolomics and integrated network pharmacology analysis reveal that ginkgolides act as potential active anticancer components by regulating one-carbon metabolism.
Zhou J, Qian M, Li C, Zhou W, Yao L, Chen Y, Abliz Z. Zhou J, et al. J Ethnopharmacol. 2022 Nov 15;298:115609. doi: 10.1016/j.jep.2022.115609. Epub 2022 Aug 8. J Ethnopharmacol. 2022. PMID: 35952968
Ginkgo biloba is a traditional Chinese medicinal with a long history, acting on the heart and lung meridians, and has been reported to have a significant effect on non-small cell lung cancer. ...The metabolomics results indicated that the ginkgolides had a significa …
Ginkgo biloba is a traditional Chinese medicinal with a long history, acting on the heart and lung meridians, and has been reported t …
Variants in folate pathway genes as modulators of genetic instability and lung cancer risk.
Piskac-Collier AL, Monroy C, Lopez MS, Cortes A, Etzel CJ, Greisinger AJ, Spitz MR, El-Zein RA. Piskac-Collier AL, et al. Genes Chromosomes Cancer. 2011 Jan;50(1):1-12. doi: 10.1002/gcc.20826. Genes Chromosomes Cancer. 2011. PMID: 20842733
Our results showed that individually, folate pathway SNPs were not associated with cytogenetic damage or lung cancer risk. However, in a polygenic disease such as lung cancer, gene-gene interactions are expected to play an important role in determining the phenotypi …
Our results showed that individually, folate pathway SNPs were not associated with cytogenetic damage or lung cancer risk. However, i …
A structural equation modelling approach to explore the role of B vitamins and immune markers in lung cancer risk.
Baltar VT, Xun WW, Johansson M, Ferrari P, Chuang SC, Relton C, Ueland PM, Midttun Ø, Slimani N, Jenab M, Clavel-Chapelon F, Boutron-Ruault MC, Fagherazzi G, Kaaks R, Rohrmann S, Boeing H, Weikert C, Bueno-de-Mesquita B, Boshuizen H, van Gils CH, Onland-Moret NC, Agudo A, Barricarte A, Navarro C, Rodríguez L, Castaño JM, Larrañaga N, Khaw KT, Wareham N, Allen NE, Crowe F, Gallo V, Norat T, Krogh V, Masala G, Panico S, Sacerdote C, Tumino R, Trichopoulou A, Lagiou P, Trichopoulos D, Rasmuson T, Hallmans G, Roswall N, Tjønneland A, Riboli E, Brennan P, Vineis P. Baltar VT, et al. Eur J Epidemiol. 2013 Aug;28(8):677-88. doi: 10.1007/s10654-013-9793-z. Epub 2013 Mar 27. Eur J Epidemiol. 2013. PMID: 23532743
Four putative mechanisms in the OCM and immunity were investigated in relation to lung cancer risk: methionine-homocysteine metabolism, folate cycle, transsulfuration, and mechanisms involved in inflammation and immune activation, all adjusted for tobacco exposure. …
Four putative mechanisms in the OCM and immunity were investigated in relation to lung cancer risk: methionine-homocysteine me …
19 results