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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1966 1
1968 3
1969 2
1970 1
1971 1
1972 1
1973 1
1974 2
1975 3
1976 1
1978 1
1981 1
1982 2
1984 1
1985 1
1986 2
1987 2
1988 4
1989 13
1990 8
1991 13
1992 22
1993 24
1994 37
1995 40
1996 41
1997 54
1998 69
1999 95
2000 99
2001 126
2002 136
2003 208
2004 264
2005 299
2006 365
2007 385
2008 451
2009 521
2010 593
2011 723
2012 851
2013 1009
2014 1180
2015 1261
2016 1326
2017 1504
2018 1658
2019 1776
2020 1941
2021 1761
2022 930
2023 813
2024 281

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18,237 results

Results by year

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Page 1
Targeting TGF-beta signal transduction for fibrosis and cancer therapy.
Peng D, Fu M, Wang M, Wei Y, Wei X. Peng D, et al. Mol Cancer. 2022 Apr 23;21(1):104. doi: 10.1186/s12943-022-01569-x. Mol Cancer. 2022. PMID: 35461253 Free PMC article. Review.
Given the critical role of TGF-beta and its downstream molecules in the progression of fibrosis and cancers, therapeutics targeting TGF-beta signaling appears to be a promising strategy. ...In this review, we summarized the biological process of TGF-beta, with its dual rol …
Given the critical role of TGF-beta and its downstream molecules in the progression of fibrosis and cancers, therapeutics targeting T …
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH).
Xu X, Poulsen KL, Wu L, Liu S, Miyata T, Song Q, Wei Q, Zhao C, Lin C, Yang J. Xu X, et al. Signal Transduct Target Ther. 2022 Aug 13;7(1):287. doi: 10.1038/s41392-022-01119-3. Signal Transduct Target Ther. 2022. PMID: 35963848 Free PMC article. Review.
Currently, lifestyle interventions are the most essential and effective strategies for preventing and controlling NAFL without the development of fibrosis. While there are still limited appropriate drugs specifically to treat NAFL/NASH, growing progress is being seen in el …
Currently, lifestyle interventions are the most essential and effective strategies for preventing and controlling NAFL without the developme …
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues.
Parola M, Pinzani M. Parola M, et al. Mol Aspects Med. 2019 Feb;65:37-55. doi: 10.1016/j.mam.2018.09.002. Epub 2018 Sep 13. Mol Aspects Med. 2019. PMID: 30213667 Free article. Review.
Liver fibrogenesis, is a dynamic, highly integrated molecular, cellular and tissue process responsible for driving the excess accumulation of extracellular matrix (ECM) components (i.e., liver fibrosis) sustained by an eterogeneous population of hepatic myofibroblasts (MFs …
Liver fibrogenesis, is a dynamic, highly integrated molecular, cellular and tissue process responsible for driving the excess accumulation o …
Ferroptosis and Liver Fibrosis.
Pan Q, Luo Y, Xia Q, He K. Pan Q, et al. Int J Med Sci. 2021 Jul 25;18(15):3361-3366. doi: 10.7150/ijms.62903. eCollection 2021. Int J Med Sci. 2021. PMID: 34522161 Free PMC article. Review.
Ferroptosis is usually accompanied with the dysfunction of lipid repair enzyme (glutathione peroxidase 4, GPX4), large masses of iron accumulation and lipid peroxidation of polyunsaturated fatty acids (PUFAs). Ferroptosis is related to several signaling pathways, including …
Ferroptosis is usually accompanied with the dysfunction of lipid repair enzyme (glutathione peroxidase 4, GPX4), large masses of iron accumu …
Pathogenesis of liver cirrhosis.
Zhou WC, Zhang QB, Qiao L. Zhou WC, et al. World J Gastroenterol. 2014 Jun 21;20(23):7312-24. doi: 10.3748/wjg.v20.i23.7312. World J Gastroenterol. 2014. PMID: 24966602 Free PMC article. Review.
Liver cirrhosis is the final pathological result of various chronic liver diseases, and fibrosis is the precursor of cirrhosis. Many types of cells, cytokines and miRNAs are involved in the initiation and progression of liver fibrosis and cirrhosis. ...At the molecu …
Liver cirrhosis is the final pathological result of various chronic liver diseases, and fibrosis is the precursor of cirrhosis. Many …
Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog.
Edeling M, Ragi G, Huang S, Pavenstädt H, Susztak K. Edeling M, et al. Nat Rev Nephrol. 2016 Jul;12(7):426-39. doi: 10.1038/nrneph.2016.54. Epub 2016 May 3. Nat Rev Nephrol. 2016. PMID: 27140856 Free PMC article. Review.
Kidney fibrosis is a common histological manifestation of functional decline in the kidney. ...Although transient activation of these pathways is needed for repair of injured tissue, their sustained activation is thought to promote fibrosis. ...
Kidney fibrosis is a common histological manifestation of functional decline in the kidney. ...Although transient activation of these …
Mechanisms of hepatic stellate cell activation.
Tsuchida T, Friedman SL. Tsuchida T, et al. Nat Rev Gastroenterol Hepatol. 2017 Jul;14(7):397-411. doi: 10.1038/nrgastro.2017.38. Epub 2017 May 10. Nat Rev Gastroenterol Hepatol. 2017. PMID: 28487545 Review.
Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic liver disease and NASH. Activation of hepatic stellate cells (HSCs) - transdiffere …
Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular matrix resulting from chronic liver inju …
TGF-beta/SMAD Pathway and Its Regulation in Hepatic Fibrosis.
Xu F, Liu C, Zhou D, Zhang L. Xu F, et al. J Histochem Cytochem. 2016 Mar;64(3):157-67. doi: 10.1369/0022155415627681. Epub 2016 Jan 8. J Histochem Cytochem. 2016. PMID: 26747705 Free PMC article. Review.
In this review, we focus on the TGF-beta/SMAD and other relative signaling pathways, and discussed the role and molecular mechanisms of TGF-beta/SMAD in the pathogenesis of hepatic fibrosis. Moreover, we address the possibility of novel therapeutic approaches to hep …
In this review, we focus on the TGF-beta/SMAD and other relative signaling pathways, and discussed the role and molecular mechanisms …
TGF-beta: the master regulator of fibrosis.
Meng XM, Nikolic-Paterson DJ, Lan HY. Meng XM, et al. Nat Rev Nephrol. 2016 Jun;12(6):325-38. doi: 10.1038/nrneph.2016.48. Epub 2016 Apr 25. Nat Rev Nephrol. 2016. PMID: 27108839 Review.
Inhibition of the TGF-beta isoform, TGF-beta1, or its downstream signalling pathways substantially limits renal fibrosis in a wide range of disease models whereas overexpression of TGF-beta1 induces renal fibrosis. ...The role of Smad proteins in the regulati …
Inhibition of the TGF-beta isoform, TGF-beta1, or its downstream signalling pathways substantially limits renal fibrosis in a …
Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3beta/beta-catenin and TGF-beta1/Smad2/3 signaling pathways.
Lv Q, Wang J, Xu C, Huang X, Ruan Z, Dai Y. Lv Q, et al. Mol Med. 2020 May 24;26(1):49. doi: 10.1186/s10020-020-00173-3. Mol Med. 2020. PMID: 32448163 Free PMC article.
This study explored the signaling pathways involved in anti-fibrosis role of PFD, thus laying a foundation for clinical application. ...In both tissues and cells, Wnt/GSK-3beta/beta-catenin and TGF-beta1/Smad2/3 signaling pathways were activated, which could …
This study explored the signaling pathways involved in anti-fibrosis role of PFD, thus laying a foundation for clinical applic …
18,237 results
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