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Page 1
Coagulopathy in COVID-19: Focus on vascular thrombotic events.
Shi W, Lv J, Lin L. Shi W, et al. J Mol Cell Cardiol. 2020 Sep;146:32-40. doi: 10.1016/j.yjmcc.2020.07.003. Epub 2020 Jul 15. J Mol Cell Cardiol. 2020. PMID: 32681845 Free PMC article. Review.
Inflammatory storm, uncontrolled inflammation-mediated endothelial injury and renin angiotensin system (RAS) dysregulation are the potential mechanisms. ...In this review, we introduce the clinical features of coagulation and the increased vascular thrombotic …
Inflammatory storm, uncontrolled inflammation-mediated endothelial injury and renin angiotensin system (RAS) dysregulat …
Persistent and progressive pulmonary fibrotic changes in a model of fat embolism.
Poisner AM, Adler F, Uhal B, McIff TE, Schroeppel JP, Mehrer A, Herndon BL, Lankachandra KM, Molteni A. Poisner AM, et al. J Trauma Acute Care Surg. 2012 Apr;72(4):992-8. doi: 10.1097/TA.0b013e31823c96b0. J Trauma Acute Care Surg. 2012. PMID: 22491616
This study detailed the persistence of the lung damage and investigated the input of the renin-angiotensin system in its pathology. ...CONCLUSIONS: This model extends the effect of FE on pulmonary pathology to 6 weeks, revealing pe …
This study detailed the persistence of the lung damage and investigated the input of the renin-angiotensin system …
Evidence for angiotensin mediation of the late histopathological effects of pulmonary fat embolism: Protection by losartan in a rat model.
Poisner A, Bass D, Fletcher A, Jain A, England JP, Davis MG, Arif D, Molteni A. Poisner A, et al. Exp Lung Res. 2018 Sep;44(7):361-367. doi: 10.1080/01902148.2018.1552339. Epub 2019 Jan 13. Exp Lung Res. 2018. PMID: 30638089
PURPOSE: In a model of fat embolism using triolein-treated rats, we have reported that the acute pulmonary histopathological changes at 48 hrs were ameliorated by the angiotensin AT1 receptor blocker losartan, the angiotensin converting enzyme inhibito …
PURPOSE: In a model of fat embolism using triolein-treated rats, we have reported that the acute pulmonary histopathological c …
COVID-19 and cancer: A guide with suggested COVID-19 rule-out criteria to support clinical decision-making.
Larson C, Oronsky B, Goyal S, Ray C, Hedjran F, Hammond TC, Kesari S, Caroen S, Lybeck M, Dobalian VE, Oronsky A, Reid T. Larson C, et al. Biochim Biophys Acta Rev Cancer. 2020 Dec;1874(2):188412. doi: 10.1016/j.bbcan.2020.188412. Epub 2020 Aug 20. Biochim Biophys Acta Rev Cancer. 2020. PMID: 32827582 Free PMC article. Review.
Moreover, because the signs and symptoms of COVID-19 are easily misattributed to the sequelae of cancer itself, such as pulmonary embolism, or its treatment, such as nausea and diarrhea, diagnosis may be delayed or missed. Potential COVID-19 rule out criteria, based …
Moreover, because the signs and symptoms of COVID-19 are easily misattributed to the sequelae of cancer itself, such as pulmonary …
The renin inhibitor aliskiren protects rat lungs from the histopathologic effects of fat embolism.
Fletcher AN, Molteni A, Ponnapureddy R, Patel C, Pluym M, Poisner AM. Fletcher AN, et al. J Trauma Acute Care Surg. 2017 Feb;82(2):338-344. doi: 10.1097/TA.0000000000001278. J Trauma Acute Care Surg. 2017. PMID: 28107310 Free PMC article.
BACKGROUND: Fat embolism (FE) and the consequent FE syndrome occurring after trauma or surgery can lead to serious pulmonary injury, including ARDS and death. Current treatment of FE syndrome is limited to supportive therapy. We have shown in a rat model that the …
BACKGROUND: Fat embolism (FE) and the consequent FE syndrome occurring after trauma or surgery can lead to serious pulmonary i …
Imbalance of angiotensin-converting enzymes affects myocardial apoptosis during cardiac arrest induced by acute pulmonary embolism in a porcine model.
Xiao HL, Zhao LX, Yang J, Tong N, An L, Liu QT, Xie MR, Li CS. Xiao HL, et al. Int J Mol Med. 2019 Apr;43(4):1575-1584. doi: 10.3892/ijmm.2019.4109. Epub 2019 Feb 26. Int J Mol Med. 2019. PMID: 30816437 Free PMC article.
Acute pulmonary embolism (APE) with cardiac arrest (CA) is associated with a high mortality rate. ...A recent study by our group discovered a post-resuscitation imbalance in the serum angiotensin-converting enzyme (ACE)2/ACE axis of the renin-angiot …
Acute pulmonary embolism (APE) with cardiac arrest (CA) is associated with a high mortality rate. ...A recent study by our gro …
Natriuretic peptides and their therapeutic potential in heart failure treatment: An updated review.
Namdari M, Eatemadi A, Negahdari B. Namdari M, et al. Cell Mol Biol (Noisy-le-grand). 2016 Sep 30;62(11):1-7. Cell Mol Biol (Noisy-le-grand). 2016. PMID: 27755944 Review.
The potency of BNP has also been researched into in cases like myocardial ischemia and infarction, cor pulmonale, and acute pulmonary embolism (PE). Based on their vaso-dilatory and diuretic properties and ability to inhibit renin-angiotensin-aldostero …
The potency of BNP has also been researched into in cases like myocardial ischemia and infarction, cor pulmonale, and acute pulmonary …
The role of renoscintigraphy and surgery in the management of Page kidney: A case report.
Chiu YL, Hu C, Lee SD, Chen PY, Wang CP. Chiu YL, et al. Medicine (Baltimore). 2017 Apr;96(16):e6560. doi: 10.1097/MD.0000000000006560. Medicine (Baltimore). 2017. PMID: 28422842 Free PMC article.
RATIONALE: Page kidney is an uncommon condition that hypertension occurs secondary to microvascular ischemia and alternation of small-vessel hemodynamics due to external compression of renal parenchyma and activation of the renin-angiotensin-aldosterone system …
RATIONALE: Page kidney is an uncommon condition that hypertension occurs secondary to microvascular ischemia and alternation of small-vessel …
Mitigating effects of captopril and losartan on lung histopathology in a rat model of fat embolism.
McIff TE, Poisner AM, Herndon B, Lankachandra K, Molteni A, Adler F. McIff TE, et al. J Trauma. 2011 May;70(5):1186-91. doi: 10.1097/TA.0b013e3181e50df6. J Trauma. 2011. PMID: 20693918
Fat embolism can lead to major pulmonary damage associated with fat embolism syndrome (FES). ...CONCLUSIONS: The results suggest that the use of drugs that act on the renin-Ang system might provide an effective and targeted therapy for fat em …
Fat embolism can lead to major pulmonary damage associated with fat embolism syndrome (FES). ...CONCLUSIONS: The result …
Perindopril effects on angiotensin I elimination in lung after experimental myocardial injury induced by intracoronary microembolization in rats.
Kalenikova EI, Gorodetskaya EA, Zacharova NV, Shechter AB, Medvedev OS. Kalenikova EI, et al. J Cardiovasc Pharmacol. 1998 Oct;32(4):608-15. doi: 10.1097/00005344-199810000-00013. J Cardiovasc Pharmacol. 1998. PMID: 9781929
Thus in rats with coronary microembolization, a higher proportion of Ang I in lung circulation is eliminated by pathways independent of angiotensin-converting enzyme. ...Our data demonstrate the cardioprotective action of perindopril based on its beneficial influenc …
Thus in rats with coronary microembolization, a higher proportion of Ang I in lung circulation is eliminated by pathways independent …