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Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia.
Marballi KK, Alganem K, Brunwasser SJ, Barkatullah A, Meyers KT, Campbell JM, Ozols AB, Mccullumsmith RE, Gallitano AL. Marballi KK, et al. Transl Psychiatry. 2022 Aug 8;12(1):320. doi: 10.1038/s41398-022-02069-8. Transl Psychiatry. 2022. PMID: 35941129 Free PMC article.
Bioinformatics and network studies have identified the immediate early gene transcription factor early growth response 3 (EGR3) as a master regulator of genes differentially expressed in the brains of patients with neuropsychiatric illnesses ranging from schizophrenia and …
Bioinformatics and network studies have identified the immediate early gene transcription factor early growth response 3 (EGR3) as a …
EGR3 Immediate Early Gene and the Brain-Derived Neurotrophic Factor in Bipolar Disorder.
Pfaffenseller B, Kapczinski F, Gallitano AL, Klamt F. Pfaffenseller B, et al. Front Behav Neurosci. 2018 Feb 5;12:15. doi: 10.3389/fnbeh.2018.00015. eCollection 2018. Front Behav Neurosci. 2018. PMID: 29459824 Free PMC article.
Bipolar disorder (BD) is a severe psychiatric illness with a consistent genetic influence, involving complex interactions between numerous genes and environmental factors. ...Considering that EGR3 expression is induced by brain-derived neurotrophic factor (BDNF) tha
Bipolar disorder (BD) is a severe psychiatric illness with a consistent genetic influence, involving complex interactions between num
The Immediate Early Gene Egr3 Is Required for Hippocampal Induction of Bdnf by Electroconvulsive Stimulation.
Meyers KT, Marballi KK, Brunwasser SJ, Renda B, Charbel M, Marrone DF, Gallitano AL. Meyers KT, et al. Front Behav Neurosci. 2018 May 11;12:92. doi: 10.3389/fnbeh.2018.00092. eCollection 2018. Front Behav Neurosci. 2018. PMID: 29867393 Free PMC article.
Early growth response 3 (Egr3) is an immediate early gene (IEG) that is regulated downstream of a cascade of genes associated with risk for psychiatric disorders, and dysfunction of Egr3 itself has been implicated in schizophrenia, bipolar disorder, and depre …
Early growth response 3 (Egr3) is an immediate early gene (IEG) that is regulated downstream of a cascade of genes associated with ri …
TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors.
Weigelt K, Carvalho LA, Drexhage RC, Wijkhuijs A, de Wit H, van Beveren NJ, Birkenhäger TK, Bergink V, Drexhage HA. Weigelt K, et al. Brain Behav Immun. 2011 Aug;25(6):1162-9. doi: 10.1016/j.bbi.2011.03.006. Epub 2011 Mar 21. Brain Behav Immun. 2011. PMID: 21421043
INTRODUCTION: Immune activation is a characteristic of schizophrenia (SCZ), bipolar disorder (BD) and unipolar major depressive disorder (MDD). ...TREM-1 expression levels correlated in particular to ATF3 and EGR3 expression levels, DAP12 expression levels correlate …
INTRODUCTION: Immune activation is a characteristic of schizophrenia (SCZ), bipolar disorder (BD) and unipolar major depressive disor …
Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer.
Tabarés-Seisdedos R, Rubenstein JL. Tabarés-Seisdedos R, et al. Mol Psychiatry. 2009 Jun;14(6):563-89. doi: 10.1038/mp.2009.2. Epub 2009 Feb 10. Mol Psychiatry. 2009. PMID: 19204725 Review.
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contri …
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2 …
Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia.
Yamada K, Gerber DJ, Iwayama Y, Ohnishi T, Ohba H, Toyota T, Aruga J, Minabe Y, Tonegawa S, Yoshikawa T. Yamada K, et al. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2815-20. doi: 10.1073/pnas.0610765104. Epub 2007 Feb 20. Proc Natl Acad Sci U S A. 2007. PMID: 17360599 Free PMC article.
In a postmortem brain study, EGR1, EGR2, and EGR3 transcripts were shown to be down-regulated in the prefrontal cortex of schizophrenic, but not bipolar, patients. These findings raise a potentially important role for EGR genes in schizophrenia pathogenesis. Because …
In a postmortem brain study, EGR1, EGR2, and EGR3 transcripts were shown to be down-regulated in the prefrontal cortex of schizophren …
Differential expression of transcriptional regulatory units in the prefrontal cortex of patients with bipolar disorder: potential role of early growth response gene 3.
Pfaffenseller B, da Silva Magalhães PV, De Bastiani MA, Castro MA, Gallitano AL, Kapczinski F, Klamt F. Pfaffenseller B, et al. Transl Psychiatry. 2016 May 10;6(5):e805. doi: 10.1038/tp.2016.78. Transl Psychiatry. 2016. PMID: 27163206 Free PMC article.
Bipolar disorder (BD) is a severe mental illness with a strong genetic component. ...With a high stringency threshold, the consensus across tests was achieved only for the EGR3 regulon. We identified EGR3 in the prefrontal cortex as a potential key target, ro
Bipolar disorder (BD) is a severe mental illness with a strong genetic component. ...With a high stringency threshold, the consensus
Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.
Mansour HA, Talkowski ME, Wood J, Chowdari KV, McClain L, Prasad K, Montrose D, Fagiolini A, Friedman ES, Allen MH, Bowden CL, Calabrese J, El-Mallakh RS, Escamilla M, Faraone SV, Fossey MD, Gyulai L, Loftis JM, Hauser P, Ketter TA, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel J, Sachs GS, Sklar P, Smoller JW, Laird N, Keshavan M, Thase ME, Axelson D, Birmaher B, Lewis D, Monk T, Frank E, Kupfer DJ, Devlin B, Nimgaonkar VL. Mansour HA, et al. Bipolar Disord. 2009 Nov;11(7):701-10. doi: 10.1111/j.1399-5618.2009.00756.x. Bipolar Disord. 2009. PMID: 19839995 Free PMC article.
OBJECTIVE: Published studies suggest associations between circadian gene polymorphisms and bipolar I disorder (BPI), as well as schizoaffective disorder (SZA) and schizophrenia (SZ). ...RESULTS: Using gene-based tests, suggestive associations were noted between EGR3
OBJECTIVE: Published studies suggest associations between circadian gene polymorphisms and bipolar I disorder (BPI), as well as schiz …
Family-based association study of early growth response gene 3 with child bipolar I disorder.
Gallitano AL, Tillman R, Dinu V, Geller B. Gallitano AL, et al. J Affect Disord. 2012 May;138(3):387-96. doi: 10.1016/j.jad.2012.01.011. Epub 2012 Feb 25. J Affect Disord. 2012. PMID: 22370066 Free PMC article.
BACKGROUND: The risk for relapse of child bipolar I disorder (BP-I) is highly correlated with environmental factors. ...The objective of this study is to evaluate whether single nucleotide polymorphisms (SNPs) in EGR genes are associated with the risk to develop child b
BACKGROUND: The risk for relapse of child bipolar I disorder (BP-I) is highly correlated with environmental factors. ...The objective …
Inflammatory gene expression in monocytes of patients with schizophrenia: overlap and difference with bipolar disorder. A study in naturalistically treated patients.
Drexhage RC, van der Heul-Nieuwenhuijsen L, Padmos RC, van Beveren N, Cohen D, Versnel MA, Nolen WA, Drexhage HA. Drexhage RC, et al. Int J Neuropsychopharmacol. 2010 Nov;13(10):1369-81. doi: 10.1017/S1461145710000799. Epub 2010 Jul 15. Int J Neuropsychopharmacol. 2010. PMID: 20633309 Free article.
Accumulating evidence indicates an activated inflammatory response system as a vulnerability factor for schizophrenia (SZ) and bipolar disorder (BD). We aimed to detect a specific inflammatory monocyte gene expression signature in SZ and compare such signature with our rec …
Accumulating evidence indicates an activated inflammatory response system as a vulnerability factor for schizophrenia (SZ) and bipolar
11 results