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Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor.
Baumgartner I, Rauh G, Pieczek A, Wuensch D, Magner M, Kearney M, Schainfeld R, Isner JM. Baumgartner I, et al. Ann Intern Med. 2000 Jun 6;132(11):880-4. doi: 10.7326/0003-4819-132-11-200006060-00005. Ann Intern Med. 2000. PMID: 10836914
BACKGROUND: Vascular endothelial growth factor (VEGF) promotes angiogenesis and vascular permeability. The extent to which VEGF may cause tissue edema in humans has not been established. OBJECTIVE: To evaluate patients undergoing VEGF gene transfer for eviden …
BACKGROUND: Vascular endothelial growth factor (VEGF) promotes angiogenesis and vascular permeability. The extent to which VEGF may cause ti …
Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: preliminary clinical results.
Isner JM, Baumgartner I, Rauh G, Schainfeld R, Blair R, Manor O, Razvi S, Symes JF. Isner JM, et al. J Vasc Surg. 1998 Dec;28(6):964-73; discussion 73-5. doi: 10.1016/s0741-5214(98)70022-9. J Vasc Surg. 1998. PMID: 9845647 Free article.
As part of a phase I clinical trial to document the safety and efficacy of intramuscular gene transfer of naked plasmid DNA-encoding vascular endothelial growth factor (phVEGF165) in the treatment of critical limb ischemia, we treated TAO in 6 patients. ...The evide …
As part of a phase I clinical trial to document the safety and efficacy of intramuscular gene transfer of naked plasmid DNA-en …
Adenoviral-mediated gene transfer of vascular endothelial growth factor in critical limb ischemia: safety results from a phase I trial.
Mohler ER 3rd, Rajagopalan S, Olin JW, Trachtenberg JD, Rasmussen H, Pak R, Crystal RG. Mohler ER 3rd, et al. Vasc Med. 2003;8(1):9-13. doi: 10.1191/1358863x03vm460oa. Vasc Med. 2003. PMID: 12866606 Clinical Trial.
All of the patients tolerated the injection well and there were no serious complications related to the procedure. Transient edema was noted in one patient. A total of 79 adverse events were reported over the course of one year. ...
All of the patients tolerated the injection well and there were no serious complications related to the procedure. Transient edema wa …
Adenovirus-mediated gene transfer of VEGF(121) improves lower-extremity endothelial function and flow reserve.
Rajagopalan S, Shah M, Luciano A, Crystal R, Nabel EG. Rajagopalan S, et al. Circulation. 2001 Aug 14;104(7):753-5. doi: 10.1161/hc3201.095192. Circulation. 2001. PMID: 11502697 Clinical Trial.
Accordingly, we investigated lower-extremity endothelial function in patients enrolled in a Phase I adenovirus-mediated gene delivery trial of VEGF(121.10). ...Peak walking times increased concomitant with improvement in endothelial function. CONCLUSIONS: Ade …
Accordingly, we investigated lower-extremity endothelial function in patients enrolled in a Phase I adenovirus-mediated gen …
Vascular endothelial growth factor-induced angiogenic gene therapy in patients with peripheral artery disease.
Kim HJ, Jang SY, Park JI, Byun J, Kim DI, Do YS, Kim JM, Kim S, Kim BM, Kim WB, Kim DK. Kim HJ, et al. Exp Mol Med. 2004 Aug 31;36(4):336-44. doi: 10.1038/emm.2004.44. Exp Mol Med. 2004. PMID: 15365252 Clinical Trial.
This phase 1 clinical trial tested the safety of intramuscular gene transfer by using naked plasmid DNA encoding the gene for VEGF, and analyzed the potential therapeutic benefits in patients with severe peripheral arterial disease (PAD). ...The study evaluat …
This phase 1 clinical trial tested the safety of intramuscular gene transfer by using naked plasmid DNA encoding the gene …
Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia.
Baumgartner I, Pieczek A, Manor O, Blair R, Kearney M, Walsh K, Isner JM. Baumgartner I, et al. Circulation. 1998 Mar 31;97(12):1114-23. doi: 10.1161/01.cir.97.12.1114. Circulation. 1998. PMID: 9537336
METHODS AND RESULTS: Gene transfer was performed in 10 limbs of 9 patients with nonhealing ischemic ulcers (n=7/10) and/or rest pain (n=10/10) due to peripheral arterial disease. ...PCR and Southern blot analyses indicated persistence of small amounts of plasmid DNA …
METHODS AND RESULTS: Gene transfer was performed in 10 limbs of 9 patients with nonhealing ischemic ulcers (n=7/10) and/or res …
Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb.
Isner JM, Pieczek A, Schainfeld R, Blair R, Haley L, Asahara T, Rosenfield K, Razvi S, Walsh K, Symes JF. Isner JM, et al. Lancet. 1996 Aug 10;348(9024):370-4. doi: 10.1016/s0140-6736(96)03361-2. Lancet. 1996. PMID: 8709735
BACKGROUND: Preclinical findings suggest that intra-arterial gene transfer of a plasmid which encodes for vascular endothelial growth factor (VEGF) can improve blood supply to the ischaemic limb. ...Three spider angiomas developed on the right foot/ankle about a wee …
BACKGROUND: Preclinical findings suggest that intra-arterial gene transfer of a plasmid which encodes for vascular endothelial …