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Year Number of Results
1867 1
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1948 2
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1951 2
1952 1
1953 1
1955 2
1956 1
1957 2
1959 1
1960 3
1961 2
1962 1
1963 1
1964 2
1965 1
1966 11
1967 7
1968 6
1969 9
1970 10
1971 8
1972 11
1973 16
1974 15
1975 53
1976 48
1977 39
1978 44
1979 62
1980 57
1981 70
1982 94
1983 130
1984 121
1985 139
1986 172
1987 153
1988 174
1989 209
1990 193
1991 204
1992 212
1993 207
1994 208
1995 208
1996 206
1997 184
1998 179
1999 154
2000 200
2001 171
2002 198
2003 186
2004 269
2005 323
2006 310
2007 311
2008 318
2009 347
2010 349
2011 327
2012 409
2013 425
2014 373
2015 403
2016 420
2017 448
2018 458
2019 455
2020 496
2021 537
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2023 564
2024 215

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11,869 results

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Page 1
Did you mean double【生物】 (729,978 results)?
First-line Systemic Treatment Options for Metastatic Castration-Sensitive Prostate Cancer: A Living Systematic Review and Network Meta-analysis.
Riaz IB, Naqvi SAA, He H, Asghar N, Siddiqi R, Liu H, Singh P, Childs DS, Ravi P, Hussain SA, Murad MH, Boorjian SA, Sweeney C, Van Allen EM, Bryce AH. Riaz IB, et al. JAMA Oncol. 2023 May 1;9(5):635-645. doi: 10.1001/jamaoncol.2022.7762. JAMA Oncol. 2023. PMID: 36862387 Free PMC article.
IMPORTANCE: The effectiveness of triplet therapy compared with androgen pathway inhibitor (API) doublets in a heterogeneous patient population with metastatic castration-sensitive prostate cancer (mCSPC) is unknown. ...CONCLUSIONS AND RELEVANCE: The potential benefit obser …
IMPORTANCE: The effectiveness of triplet therapy compared with androgen pathway inhibitor (API) doublets in a heterogeneous patient p …
Benchmarking Computational Doublet-Detection Methods for Single-Cell RNA Sequencing Data.
Xi NM, Li JJ. Xi NM, et al. Cell Syst. 2021 Feb 17;12(2):176-194.e6. doi: 10.1016/j.cels.2020.11.008. Epub 2020 Dec 17. Cell Syst. 2021. PMID: 33338399 Free PMC article.
In single-cell RNA sequencing (scRNA-seq), doublets form when two cells are encapsulated into one reaction volume. ...We conducted a systematic benchmark study of nine cutting-edge computational doublet-detection methods. Our study included 16 real datasets, which c …
In single-cell RNA sequencing (scRNA-seq), doublets form when two cells are encapsulated into one reaction volume. ...We conducted a …
DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors.
McGinnis CS, Murrow LM, Gartner ZJ. McGinnis CS, et al. Cell Syst. 2019 Apr 24;8(4):329-337.e4. doi: 10.1016/j.cels.2019.03.003. Epub 2019 Apr 3. Cell Syst. 2019. PMID: 30954475 Free PMC article.
Here, we present a computational doublet detection tool-DoubletFinder-that identifies doublets using only gene expression data. ...We first use scRNA-seq datasets where the identity of doublets is known to show that DoubletFinder identifies doublets fo …
Here, we present a computational doublet detection tool-DoubletFinder-that identifies doublets using only gene expression data …
Axonemal Dynein Arms.
King SM. King SM. Cold Spring Harb Perspect Biol. 2016 Nov 1;8(11):a028100. doi: 10.1101/cshperspect.a028100. Cold Spring Harb Perspect Biol. 2016. PMID: 27527589 Free PMC article. Review.
Axonemal dyneins form the inner and outer rows of arms associated with the doublet microtubules of motile cilia. These enzymes convert the chemical energy released from adenosine triphosphate (ATP) hydrolysis into mechanical work by causing the doublets to slide wit …
Axonemal dyneins form the inner and outer rows of arms associated with the doublet microtubules of motile cilia. These enzymes conver …
Bursting Rate Variability.
Martin Del Campo Vera R, Jonckheere E. Martin Del Campo Vera R, et al. Front Physiol. 2021 Dec 2;12:724027. doi: 10.3389/fphys.2021.724027. eCollection 2021. Front Physiol. 2021. PMID: 34925052 Free PMC article.
Not only does it manifest itself visually as a train of short periods of accrued surface electromyographic (sEMG) activity in the traces, but it has a deeper underpinning because the sEMG bursts are synchronous with wavelet packets in the D8 subband of the Daubechies 3 (db3) wave …
Not only does it manifest itself visually as a train of short periods of accrued surface electromyographic (sEMG) activity in the traces, bu …
Current Chemotherapy Use in Neuroendocrine Tumors.
Chan DL, Singh S. Chan DL, et al. Endocrinol Metab Clin North Am. 2018 Sep;47(3):603-614. doi: 10.1016/j.ecl.2018.04.006. Endocrinol Metab Clin North Am. 2018. PMID: 30098718 Review.
In contrast, poorly differentiated grade 3 NETs are usually treated with platinum doublet chemotherapy. There is no consensus for the treatment of well-differentiated G3 NETs, but platinum doublets or CAPTEM are reasonable options....
In contrast, poorly differentiated grade 3 NETs are usually treated with platinum doublet chemotherapy. There is no consensus for the …
Codon context.
Buckingham RH. Buckingham RH. Experientia. 1990 Dec 1;46(11-12):1126-33. doi: 10.1007/BF01936922. Experientia. 1990. PMID: 2253710 Review.
The analysis of coding sequences reveals nonrandomness in the context of both sense and stop codons. Part of this is related to nucleotide doublet preference, seen also in non-coding sequences and thought to arise from the dependence of mutational events on surrounding seq …
The analysis of coding sequences reveals nonrandomness in the context of both sense and stop codons. Part of this is related to nucleotide …
Clustering single-cell multi-omics data with MoClust.
Yuan M, Chen L, Deng M. Yuan M, et al. Bioinformatics. 2023 Jan 1;39(1):btac736. doi: 10.1093/bioinformatics/btac736. Bioinformatics. 2023. PMID: 36383167 Free PMC article.
However, multi-omics data have the properties of inherited large dimension, high sparsity and existence of doublets. Moreover, representations of different omics from even the same cell follow diverse distributions. ...RESULTS: We developed MoClust, a novel joint clusterin …
However, multi-omics data have the properties of inherited large dimension, high sparsity and existence of doublets. Moreover, repres …
Structural insights into the architecture and assembly of eukaryotic flagella.
Petriman NA, Lorentzen E. Petriman NA, et al. Microb Cell. 2020 Sep 21;7(11):289-299. doi: 10.15698/mic2020.11.734. Microb Cell. 2020. PMID: 33150161 Free PMC article. Review.
These include the recently reported purification and structure determination of axonemal doublet microtubules from the green algae Chlamydomonas reinhardtii, which allows for the modeling of more than 30 associated protein factors to provide deep molecular insight into the …
These include the recently reported purification and structure determination of axonemal doublet microtubules from the green algae Ch …
Microstructure-Based Modeling of Primary Cilia Mechanics.
Mostafazadeh N, Resnick A, Young YN, Peng Z. Mostafazadeh N, et al. bioRxiv [Preprint]. 2023 Jul 15:2023.07.14.549117. doi: 10.1101/2023.07.14.549117. bioRxiv. 2023. PMID: 37503231 Free PMC article. Preprint.
Second, by integrating the cilium membrane with nine microtubule doublets, we found that the microtubule doublets may twist significantly as the whole cilium bends. ...SIGNIFICANCE: Factors regulating the mechanical response of a primary cilium to fluid flow remain …
Second, by integrating the cilium membrane with nine microtubule doublets, we found that the microtubule doublets may twist si …
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