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Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum.
Andreasen NC, Carson R, Diksic M, Evans A, Farde L, Gjedde A, Hakim A, Lal S, Nair N, Sedvall G, et al. Andreasen NC, et al. Schizophr Bull. 1988;14(3):471-84. doi: 10.1093/schbul/14.3.471. Schizophr Bull. 1988. PMID: 2975043 Review.
Recently, two research groups published numbers for D2 receptor sites in the neostriatum of drug-naive schizophrenic patients, obtained in vivo by positron emission tomography (PET). ...
Recently, two research groups published numbers for D2 receptor sites in the neostriatum of drug-naive schizophrenic patients, obtain …
Dopamine D2 receptor binding in drug-naive patients with schizophrenia examined with raclopride-C11 and positron emission tomography.
Talvik M, Nordström AL, Okubo Y, Olsson H, Borg J, Halldin C, Farde L. Talvik M, et al. Psychiatry Res. 2006 Dec 1;148(2-3):165-73. doi: 10.1016/j.pscychresns.2006.05.009. Epub 2006 Nov 13. Psychiatry Res. 2006. PMID: 17095199
The aim was to test the dopamine hypothesis of schizophrenia in a further analysis of D(2)-like dopamine binding using the radioligand [(11)C]raclopride and high resolution 3-dimensional (3D) PET. ...This finding is in agreement with two previous studi …
The aim was to test the dopamine hypothesis of schizophrenia in a further analysis of D(2)-like dopamine binding using …
Dopamine D4 receptors and effects of guanine nucleotides on [3H]raclopride binding in postmortem caudate nucleus of subjects with schizophrenia or major depression.
Sumiyoshi T, Stockmeier CA, Overholser JC, Thompson PA, Meltzer HY. Sumiyoshi T, et al. Brain Res. 1995 May 29;681(1-2):109-16. doi: 10.1016/0006-8993(95)00301-6. Brain Res. 1995. PMID: 7552267
The densities of dopamine-D4 receptors were determined in postmortem samples of caudate nucleus from patients with schizophrenia (n = 9) and age-matched controls (n = 10). ...These results confirm a previous report of Seeman et al. (1993) and suggest that measurable …
The densities of dopamine-D4 receptors were determined in postmortem samples of caudate nucleus from patients with schizophrenia …
Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia.
Arakawa R, Ito H, Takano A, Takahashi H, Morimoto T, Sassa T, Ohta K, Kato M, Okubo Y, Suhara T. Arakawa R, et al. Psychopharmacology (Berl). 2008 Apr;197(2):229-35. doi: 10.1007/s00213-007-1029-z. Epub 2007 Dec 6. Psychopharmacology (Berl). 2008. PMID: 18058087
OBJECTIVES: In this study, we measured striatal and extrastriatal dopamine D2 receptor occupancy during paliperidone ER treatment in patients with schizophrenia using positron emission tomography (PET) to compare regional occupancy and to estimate the optimal dose. …
OBJECTIVES: In this study, we measured striatal and extrastriatal dopamine D2 receptor occupancy during paliperidone ER treatment in …
Selective D1- and D2-dopamine receptor blockade both induces akathisia in humans--a PET study with [11C]SCH 23390 and [11C]raclopride.
Farde L. Farde L. Psychopharmacology (Berl). 1992;107(1):23-9. doi: 10.1007/BF02244961. Psychopharmacology (Berl). 1992. PMID: 1534178
The akathisia was transient and occurred only when [11C]SCH 23390 binding in the basal ganglia was at a high level with a central D1-dopamine receptor occupancy of 45-59%. The D2-dopamine receptor antagonist [11C]raclopride was injected IV into 20 healthy sub …
The akathisia was transient and occurred only when [11C]SCH 23390 binding in the basal ganglia was at a high level with a central D1-dopa …
Antagonistic interaction between adenosine A2A receptors and dopamine D2 receptors in the ventral striopallidal system. Implications for the treatment of schizophrenia.
Ferré S, O'Connor WT, Snaprud P, Ungerstedt U, Fuxe K. Ferré S, et al. Neuroscience. 1994 Dec;63(3):765-73. doi: 10.1016/0306-4522(94)90521-5. Neuroscience. 1994. PMID: 7898676
Recent studies have shown the existence of a specific antagonistic interaction between adenosine A2a receptors and dopamine D2 receptors in the brain. This A2a-D2 interaction seems to be essential for the behavioural effects of adenosine agonists and antagonists, like caff …
Recent studies have shown the existence of a specific antagonistic interaction between adenosine A2a receptors and dopamine D2 recept …
Increased synaptic dopamine function in associative regions of the striatum in schizophrenia.
Kegeles LS, Abi-Dargham A, Frankle WG, Gil R, Cooper TB, Slifstein M, Hwang DR, Huang Y, Haber SN, Laruelle M. Kegeles LS, et al. Arch Gen Psychiatry. 2010 Mar;67(3):231-9. doi: 10.1001/archgenpsychiatry.2010.10. Arch Gen Psychiatry. 2010. PMID: 20194823
MAIN OUTCOME MEASURES: Percentage change in dopamine D(2) receptor availability in striatal subregions within each subject measured by positron emission tomography with carbon 11-labeled raclopride before and during pharmacologically induced dopamine depletio …
MAIN OUTCOME MEASURES: Percentage change in dopamine D(2) receptor availability in striatal subregions within each subject measured b …
Systemic inflammation enhances stimulant-induced striatal dopamine elevation.
Petrulli JR, Kalish B, Nabulsi NB, Huang Y, Hannestad J, Morris ED. Petrulli JR, et al. Transl Psychiatry. 2017 Mar 28;7(3):e1076. doi: 10.1038/tp.2017.18. Transl Psychiatry. 2017. PMID: 28350401 Free PMC article. Clinical Trial.
Changes in the mesolimbic dopamine (DA) system are implicated in a range of neuropsychiatric conditions including addiction, depression and schizophrenia. ...The goal of this study was to use positron emission tomography with the dopamine D(2) antagonist trac …
Changes in the mesolimbic dopamine (DA) system are implicated in a range of neuropsychiatric conditions including addiction, depressi …
A sex- and region-specific role of Akt1 in the modulation of methamphetamine-induced hyperlocomotion and striatal neuronal activity: implications in schizophrenia and methamphetamine-induced psychosis.
Chen YW, Kao HY, Min MY, Lai WS. Chen YW, et al. Schizophr Bull. 2014 Mar;40(2):388-98. doi: 10.1093/schbul/sbt031. Epub 2013 Mar 8. Schizophr Bull. 2014. PMID: 23474853 Free PMC article.
AKT1 (also known as protein kinase B, alpha), a serine/threonine kinase of AKT family, has been implicated in both schizophrenia and methamphetamine (Meth) use disorders. AKT1 or its protein also has epistatic effects on the regulation of dopamine-dependent behavior …
AKT1 (also known as protein kinase B, alpha), a serine/threonine kinase of AKT family, has been implicated in both schizophrenia and …
The binding of both [3H]nemonapride and [3H]raclopride is increased in schizophrenia.
Marzella PL, Hill C, Keks N, Singh B, Copolov D. Marzella PL, et al. Biol Psychiatry. 1997 Oct 15;42(8):648-54. doi: 10.1016/s0006-3223(96)00471-4. Biol Psychiatry. 1997. PMID: 9325557
We performed a postmortem autoradiographic study to compare the density of dopamine D4-like sites in caudate putamen section from age-matched schizophrenia (n = 15) and control (n = 15) populations. ...The findings revealed that in the schizophrenia populatio …
We performed a postmortem autoradiographic study to compare the density of dopamine D4-like sites in caudate putamen section from age …
43 results