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1983 1
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1999 3
2000 1
2001 1
2002 3
2003 2
2004 5
2005 1
2006 3
2007 4
2008 6
2009 6
2010 1
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2012 7
2013 8
2014 4
2015 2
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L-3,4-Dihydroxy-6-[18F]fluorophenylalanine.
Leung K. Leung K. 2005 Mar 21 [updated 2011 Dec 21]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2005 Mar 21 [updated 2011 Dec 21]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641250 Free Books & Documents. Review.
Dopamine is synthesized within nerve cells (3). L-tyrosine is converted to dihydroxyphenylalanine (L-DOPA) and then to dopamine in a two-step process. ...The second step is catalyzed by aromatic L-amino acid decarboxylase (L-DOPA decarboxylase, AAAD). In part …
Dopamine is synthesized within nerve cells (3). L-tyrosine is converted to dihydroxyphenylalanine (L-DOPA) and then to dopamin …
The role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders.
Cheng PWC, Chang WC, Lo GG, Chan KWS, Lee HME, Hui LMC, Suen YN, Leung YLE, Au Yeung KMP, Chen S, Mak KFH, Sham PC, Santangelo B, Veronese M, Ho CL, Chen YHE, Howes OD. Cheng PWC, et al. Neuropsychopharmacology. 2020 Oct;45(11):1870-1876. doi: 10.1038/s41386-020-0740-x. Epub 2020 Jul 1. Neuropsychopharmacology. 2020. PMID: 32612207 Free PMC article.
There have been few studies performed to examine the pathophysiological differences between different types of psychosis, such as between delusional disorder (DD) and schizophrenia (SZ). Notably, despite the different clinical characteristics of DD and schizophrenia …
There have been few studies performed to examine the pathophysiological differences between different types of psychosis, such as between de …
4-[18F]Fluoro-l-m-tyrosine.
The MICAD Research Team. The MICAD Research Team. 2006 Oct 11 [updated 2006 Nov 9]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2006 Oct 11 [updated 2006 Nov 9]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641732 Free Books & Documents. Review.
4-[(18)F]Fluoro-l-m-tyrosine (4-[(18)F]FMT) is a noncatecholic radioligand developed for positron emission tomography (PET) imaging of dopaminergic metabolism and function in the central nervous system (CNS) (1, 2). It is an analog of dihydroxyphenylalanin …
4-[(18)F]Fluoro-l-m-tyrosine (4-[(18)F]FMT) is a noncatecholic radioligand developed for positron emission tomography ( …
6-[18F]Fluoro-l-m-tyrosine.
The MICAD Research Team. The MICAD Research Team. 2006 May 22 [updated 2006 Sep 6]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2006 May 22 [updated 2006 Sep 6]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641693 Free Books & Documents. Review.
6-[(18)F]Fluoro-l-m-tyrosine (6-[(18)F]FMT) is a noncatecholic radioligand developed for positron emission tomography (PET) imaging of dopaminergic metabolism and function in the central nervous system (CNS). It is an analog of dihydroxyphenylalanine ( …
6-[(18)F]Fluoro-l-m-tyrosine (6-[(18)F]FMT) is a noncatecholic radioligand developed for positron emission tomography ( …
6-(18)F-DOPA PET study in patients with schizophrenia. Positron emission tomography.
Elkashef AM, Doudet D, Bryant T, Cohen RM, Li SH, Wyatt RJ. Elkashef AM, et al. Psychiatry Res. 2000 Nov 20;100(1):1-11. doi: 10.1016/s0925-4927(00)00064-0. Psychiatry Res. 2000. PMID: 11090720
Presynaptic dopamine metabolism was studied in a group of patients with schizophrenia and in an age- and gender-matched normal control group using 6-[(18)F]fluoro-L-DOPA ((18)F-DOPA) and positron emission tomography (PET). ...The 18F-D …
Presynaptic dopamine metabolism was studied in a group of patients with schizophrenia and in an age- and gender-matched normal contro …
Dopaminergic Activity in Antipsychotic-Naive Patients Assessed With Positron Emission Tomography Before and After Partial Dopamine D(2) Receptor Agonist Treatment: Association With Psychotic Symptoms and Treatment Response.
Sigvard AK, Nielsen MØ, Gjedde A, Bojesen KB, Fuglø D, Tangmose K, Kumakura Y, Heltø K, Ebdrup BH, Jensen LT, Rostrup E, Glenthøj BY. Sigvard AK, et al. Biol Psychiatry. 2022 Jan 15;91(2):236-245. doi: 10.1016/j.biopsych.2021.08.023. Epub 2021 Sep 10. Biol Psychiatry. 2022. PMID: 34743917 Free article.
Our study used a four-parameter model to test the association between the striatal decarboxylation rate of (18)F-DOPA to (18)F-dopamine (k(3)) and the effect of treatment on psychotic symptoms in antipsychotic-naive patients with first-episode psychosis. ...METHODS: Sixty- …
Our study used a four-parameter model to test the association between the striatal decarboxylation rate of (18)F-DOPA to (18)F-dopami …
Mesolimbic Dopamine Function Is Related to Salience Network Connectivity: An Integrative Positron Emission Tomography and Magnetic Resonance Study.
McCutcheon RA, Nour MM, Dahoun T, Jauhar S, Pepper F, Expert P, Veronese M, Adams RA, Turkheimer F, Mehta MA, Howes OD. McCutcheon RA, et al. Biol Psychiatry. 2019 Mar 1;85(5):368-378. doi: 10.1016/j.biopsych.2018.09.010. Epub 2018 Sep 29. Biol Psychiatry. 2019. PMID: 30389131 Free PMC article.
BACKGROUND: A wide range of neuropsychiatric disorders, from schizophrenia to drug addiction, involve abnormalities in both the mesolimbic dopamine system and the cortical salience network. ...Preclinical research has suggested that the firing of mesolimbic dopamine neuron …
BACKGROUND: A wide range of neuropsychiatric disorders, from schizophrenia to drug addiction, involve abnormalities in both the mesol …
Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study.
Howes OD, Williams M, Ibrahim K, Leung G, Egerton A, McGuire PK, Turkheimer F. Howes OD, et al. Brain. 2013 Nov;136(Pt 11):3242-51. doi: 10.1093/brain/awt264. Epub 2013 Oct 3. Brain. 2013. PMID: 24097339 Free PMC article.
Elevated in vivo markers of presynaptic striatal dopamine activity have been a consistent finding in schizophrenia, and include a large effect size elevation in dopamine synthesis capacity. ...In an in vivo imaging study, nigral and striatal dopaminergic function was measu …
Elevated in vivo markers of presynaptic striatal dopamine activity have been a consistent finding in schizophrenia, and include a lar …
Presynaptic dopaminergic dysfunction in schizophrenia: a positron emission tomographic [18F]fluorodopa study.
McGowan S, Lawrence AD, Sales T, Quested D, Grasby P. McGowan S, et al. Arch Gen Psychiatry. 2004 Feb;61(2):134-42. doi: 10.1001/archpsyc.61.2.134. Arch Gen Psychiatry. 2004. PMID: 14757589
OBJECTIVE: To assess presynaptic dopaminergic function in a large cohort of patients with schizophrenia by means of [18F]fluorodopa uptake and a high-sensitivity 3-dimensional positron emission tomograph. ...INTERVENTION: [18F]fluorodopa positron em …
OBJECTIVE: To assess presynaptic dopaminergic function in a large cohort of patients with schizophrenia by means of [18F]fluorodopa u …
Dopamine receptors and transporters in Parkinson's disease and schizophrenia.
Seeman P, Niznik HB. Seeman P, et al. FASEB J. 1990 Jul;4(10):2737-44. doi: 10.1096/fasebj.4.10.2197154. FASEB J. 1990. PMID: 2197154 Review.
Positron emission tomography (PET) data and in vitro data generally concur. ...The D2 receptor density, however, is consistently elevated in postmortem brain putamen and caudate nucleus, even in tissues from neuroleptic-free or drug-naive patients. Three sets …
Positron emission tomography (PET) data and in vitro data generally concur. ...The D2 receptor density, however, is con …
82 results