Send to:

Choose Destination

See 1 citation found by title matching your search:

See comment in PubMed Commons below
Nat Genet. 2011 Dec 27;44(1):13-4. doi: 10.1038/ng.1043.

Dnmt3a silences hematopoietic stem cell self-renewal.

Author information

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts, USA.


DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk