Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 4
2008 2
2009 1
2010 2
2011 1
2013 1
2014 4
2015 4
2016 4
2018 4
2019 3
2020 2
2021 4
2022 2
2023 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

32 results

Results by year

Filters applied: . Clear all
Page 1
Genetic Predisposition to Schizophrenia and Depressive Disorder Comorbidity.
Shnayder NA, Novitsky MA, Neznanov NG, Limankin OV, Asadullin AR, Petrov AV, Dmitrenko DV, Narodova EA, Popenko NV, Nasyrova RF. Shnayder NA, et al. Genes (Basel). 2022 Mar 2;13(3):457. doi: 10.3390/genes13030457. Genes (Basel). 2022. PMID: 35328011 Free PMC article. Review.
Background: Patients with schizophrenia have an increased risk of depressive disorders compared to the general population. The comorbidity between schizophrenia and depression suggests a potential coincidence of the pathophysiology and/or genetic predictors of these …
Background: Patients with schizophrenia have an increased risk of depressive disorders compared to the general population. The comorb …
Interneuronal NMDA receptors regulate long-term depression and motor learning in the cerebellum.
Kono M, Kakegawa W, Yoshida K, Yuzaki M. Kono M, et al. J Physiol. 2019 Feb;597(3):903-920. doi: 10.1113/JP276794. Epub 2018 Nov 24. J Physiol. 2019. PMID: 30382582 Free PMC article.
Here, we examined the contribution of NMDARs expressed in granule cells (GCs), PCs and molecular-layer interneurons (MLIs) to LTD/LTP and motor learning by generating GC-, PC- and MLI/PC-specific knockouts of Grin1, a gene encoding an obligatory GluN1 subunit of NMDARs. Wh …
Here, we examined the contribution of NMDARs expressed in granule cells (GCs), PCs and molecular-layer interneurons (MLIs) to LTD/LTP and mo …
Role of copper in depression. Relationship with ketamine treatment.
Słupski J, Cubała WJ, Górska N, Gałuszko-Węgielnik M, Wiglusz MS. Słupski J, et al. Med Hypotheses. 2018 Oct;119:14-17. doi: 10.1016/j.mehy.2018.07.012. Epub 2018 Jul 17. Med Hypotheses. 2018. PMID: 30122482
Depression is one of the most common psychiatric issues with a proportion of adults with major depressive disorder who fail to achieve remission with index pharmacological treatment. ...Accumulating evidence suggests that the N-Methyl-d-aspartate receptor (NM …
Depression is one of the most common psychiatric issues with a proportion of adults with major depressive disorder who …
Synaptic dysfunction in Parkinson's disease.
Bagetta V, Ghiglieri V, Sgobio C, Calabresi P, Picconi B. Bagetta V, et al. Biochem Soc Trans. 2010 Apr;38(2):493-7. doi: 10.1042/BST0380493. Biochem Soc Trans. 2010. PMID: 20298209 Review.
In neuronal circuits, memory storage depends on activity-dependent modifications in synaptic efficacy, such as LTD (long-term depression) and LTP (long-term potentiation), the two main forms of synaptic plasticity in the brain. ...It has been suggested that their impairmen …
In neuronal circuits, memory storage depends on activity-dependent modifications in synaptic efficacy, such as LTD (long-term depression …
GRIN2B gene expression is increased in the anterior cingulate cortex in major depression.
Brown SJ, Brown AM, Purves-Tyson TD, Huang XF, Shannon Weickert C, Newell KA. Brown SJ, et al. J Psychiatr Res. 2023 Apr;160:204-209. doi: 10.1016/j.jpsychires.2023.02.017. Epub 2023 Feb 16. J Psychiatr Res. 2023. PMID: 36848775 Free article.
The glutamatergic system may be central to the neurobiology and treatment of major depressive disorder (MDD) and psychosis. Despite the success of N-methyl-D-aspartate receptor (NMDAR) antagonists for the treatment of MDD, little is known regarding the expression of …
The glutamatergic system may be central to the neurobiology and treatment of major depressive disorder (MDD) and psychosis. De …
Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry.
Weder N, Zhang H, Jensen K, Yang BZ, Simen A, Jackowski A, Lipschitz D, Douglas-Palumberi H, Ge M, Perepletchikova F, O'Loughlin K, Hudziak JJ, Gelernter J, Kaufman J. Weder N, et al. J Am Acad Child Adolesc Psychiatry. 2014 Apr;53(4):417-24.e5. doi: 10.1016/j.jaac.2013.12.025. Epub 2014 Jan 27. J Am Acad Child Adolesc Psychiatry. 2014. PMID: 24655651 Free PMC article.

RESULTS: Methylation in 3 genes emerged as genome-wide-significant predictors of depression: DNA-Binding Protein Inhibitor ID-3 (ID3); Glutamate Receptor, Ionotropic N-methyl-D-aspartate (NMDA) 1 (GRIN1); and Tubulin Polymerization Promoting Protein (TPPP) (p < 5

…
RESULTS: Methylation in 3 genes emerged as genome-wide-significant predictors of depression: DNA-Binding Protein Inhibitor ID-3 (ID3) …
Cre-Activation in ErbB4-Positive Neurons of Floxed Grin1/NMDA Receptor Mice Is Not Associated With Major Behavioral Impairment.
Mallien AS, Pfeiffer N, Vogt MA, Chourbaji S, Sprengel R, Gass P, Inta D. Mallien AS, et al. Front Psychiatry. 2021 Nov 25;12:750106. doi: 10.3389/fpsyt.2021.750106. eCollection 2021. Front Psychiatry. 2021. PMID: 34899420 Free PMC article.
Extensive evidence suggests a dysfunction of the glutamate NMDA receptor (NMDAR) in schizophrenia, a severe psychiatric disorder with putative early neurodevelopmental origins, but clinical onset mainly during late adolescence. ...Interestingly, the tamoxifen-inducible NMD …
Extensive evidence suggests a dysfunction of the glutamate NMDA receptor (NMDAR) in schizophrenia, a severe psychiatric disorder with …
What DNA methylation modifications and/or genetic variations interact with childhood maltreatment in the development of depression: A systematic review.
Misra P, Liu S, Meng X. Misra P, et al. J Affect Disord. 2019 Jun 1;252:325-333. doi: 10.1016/j.jad.2019.04.049. Epub 2019 Apr 9. J Affect Disord. 2019. PMID: 30999089
BACKGROUND: Child maltreatment predicts a significant risk factor for depression. The relationship between child maltreatment and depression has been shown to vary as a function of genetic factors. ...All the selected studies were from the United States and publishe …
BACKGROUND: Child maltreatment predicts a significant risk factor for depression. The relationship between child maltreatment and …
Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats.
Yawalkar R, Changotra H, Gupta GL. Yawalkar R, et al. Neurochem Int. 2018 Sep;118:73-81. doi: 10.1016/j.neuint.2018.04.011. Epub 2018 Apr 25. Neurochem Int. 2018. PMID: 29704590
Evidences have indicated a high degree of comorbidity of alcoholism and depression. N-acetylcysteine (NAC) has shown its clinical efficiency in the treatment of several psychiatric disorders and is identified as a multi-target acting drug. The ability of NAC to prevent alc …
Evidences have indicated a high degree of comorbidity of alcoholism and depression. N-acetylcysteine (NAC) has shown its clinical eff …
Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample.
Georgi A, Jamra RA, Klein K, Villela AW, Schumacher J, Becker T, Paul T, Schmael C, Höfels S, Klopp N, Illig T, Propping P, Cichon S, Nöthen MM, Schulze TG, Rietschel M. Georgi A, et al. Psychiatr Genet. 2007 Oct;17(5):308-10. doi: 10.1097/YPG.0b013e3280c1e5fb. Psychiatr Genet. 2007. PMID: 17728671
Genetic variation in glutamatergic signalling pathways is believed to play a substantial role in the aetiology of schizophrenia. The N-methyl-D-aspartate receptor subunit gene GRIN1 has been proposed as a candidate gene for schizophrenia. We tested for a potential associat …
Genetic variation in glutamatergic signalling pathways is believed to play a substantial role in the aetiology of schizophrenia. The N-methy …
32 results