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Activins in reproductive biology and beyond.

Wijayarathna R, de Kretser DM.

Hum Reprod Update. 2016 Apr;22(3). pii: dmv058. doi: 10.1093/humupd/dmv058. Epub 2016 Feb 15. Review.


Substantial Increases Occur in Serum Activins and Follistatin during Lung Transplantation.

de Kretser DM, Bensley JG, Phillips DJ, Levvey BJ, Snell GI, Lin E, Hedger MP, O'Hehir RE.

PLoS One. 2016 Jan 28;11(1):e0140948. doi: 10.1371/journal.pone.0140948. eCollection 2016.


Endocrinology of the Male Reproductive System.

de Kretser DM, O'Donnell L.

In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, Koch C, McLachlan R, New M, Rebar R, Singer F, Vinik A, Weickert MO, editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-.
2013 Jan 8.


LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.

Liu Y, DeBoer K, de Kretser DM, O'Donnell L, O'Connor AE, Merriner DJ, Okuda H, Whittle B, Jans DA, Efthymiadis A, McLachlan RI, Ormandy CJ, Goodnow CC, Jamsai D, O'Bryan MK.

PLoS Genet. 2015 Mar 17;11(3):e1005090. doi: 10.1371/journal.pgen.1005090. eCollection 2015 Mar.


The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology.

Hardy CL, King SJ, Mifsud NA, Hedger MP, Phillips DJ, Mackay F, de Kretser DM, Wilson JW, Rolland JM, O'Hehir RE.

Immunol Cell Biol. 2015 Jul;93(6):567-74. doi: 10.1038/icb.2015.7. Epub 2015 Mar 10.


Serum activin A and B, and follistatin in critically ill patients with influenza A(H1N1) infection.

Linko R, Hedger MP, Pettilä V, Ruokonen E, Ala-Kokko T, Ludlow H, de Kretser DM.

BMC Infect Dis. 2014 May 10;14:253. doi: 10.1186/1471-2334-14-253.


Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus.

Holdsworth-Carson SJ, Craythorn RG, Winnall WR, Dhaliwal K, Genovese R, Nowell CJ, Rogers PA, de Kretser DM, Hedger MP, Girling JE.

Reprod Fertil Dev. 2014 Mar 17. doi: 10.1071/RD13372. [Epub ahead of print]


Follistatin is induced by ionizing radiation and potentially predictive of radiosensitivity in radiation-induced fibrosis patient derived fibroblasts.

Forrester HB, Ivashkevich A, McKay MJ, Leong T, de Kretser DM, Sprung CN.

PLoS One. 2013 Oct 18;8(10):e77119. doi: 10.1371/journal.pone.0077119. eCollection 2013.


Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study.

de Kretser DM, Bensley JG, Pettilä V, Linko R, Hedger MP, Hayward S, Allan CA, McLachlan RI, Ludlow H, Phillips DJ.

Crit Care. 2013 Oct 31;17(5):R263. doi: 10.1186/cc13093.


Loss of the nuclear receptor corepressor SLIRP compromises male fertility.

Colley SM, Wintle L, Searles R, Russell V, Firman RC, Smith S, Deboer K, Merriner DJ, Genevieve B, Bentel JM, Stuckey BG, Phillips MR, Simmons LW, de Kretser DM, O'Bryan MK, Leedman PJ.

PLoS One. 2013 Aug 15;8(8):e70700. doi: 10.1371/journal.pone.0070700. eCollection 2013.


The activins and their binding protein, follistatin-Diagnostic and therapeutic targets in inflammatory disease and fibrosis.

Hedger MP, de Kretser DM.

Cytokine Growth Factor Rev. 2013 Jun;24(3):285-95. doi: 10.1016/j.cytogfr.2013.03.003. Epub 2013 Mar 29. Review.


Male reproductive health disorders among Aboriginal and Torres Strait Islander men: a hidden problem?

Adams MJ, Collins VR, Dunne MP, de Kretser DM, Holden CA.

Med J Aust. 2013 Jan 21;198(1):33-8.


Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens.

Winnall WR, Wu H, Sarraj MA, Rogers PA, de Kretser DM, Girling JE, Hedger MP.

Reprod Fertil Dev. 2013;25(3):570-80. doi: 10.1071/RD11287.


Phenotypic assessment of male fertility status in transgenic animal models.

de Kretser DM, O'Donnell L.

Methods Mol Biol. 2013;927:531-48.


An essential role for katanin p80 and microtubule severing in male gamete production.

O'Donnell L, Rhodes D, Smith SJ, Merriner DJ, Clark BJ, Borg C, Whittle B, O'Connor AE, Smith LB, McNally FJ, de Kretser DM, Goodnow CC, Ormandy CJ, Jamsai D, O'Bryan MK.

PLoS Genet. 2012;8(5):e1002698. doi: 10.1371/journal.pgen.1002698. Epub 2012 May 24.


Progesterone stimulates expression of follistatin splice variants Fst288 and Fst315 in the mouse uterus.

Craythorn RG, Winnall WR, Lederman F, Gold EJ, O'Connor AE, de Kretser DM, Hedger MP, Rogers PA, Girling JE.

Reprod Biomed Online. 2012 Mar;24(3):364-74. doi: 10.1016/j.rbmo.2011.12.004. Epub 2011 Dec 20.


The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair.

de Kretser DM, O'Hehir RE, Hardy CL, Hedger MP.

Mol Cell Endocrinol. 2012 Aug 15;359(1-2):101-6. doi: 10.1016/j.mce.2011.10.009. Epub 2011 Oct 20. Review.


The regulation and functions of activin and follistatin in inflammation and immunity.

Hedger MP, Winnall WR, Phillips DJ, de Kretser DM.

Vitam Horm. 2011;85:255-97. doi: 10.1016/B978-0-12-385961-7.00013-5. Review.


A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice.

Youngson NA, Vickaryous N, van der Horst A, Epp T, Harten S, Fleming JS, Khanna KK, de Kretser DM, Whitelaw E.

Mamm Genome. 2011 Apr;22(3-4):235-48. doi: 10.1007/s00335-011-9317-7. Epub 2011 Feb 24.


Determinants of male health: the interaction of biological and social factors.

de Kretser DM.

Asian J Androl. 2010 May;12(3):291-7. doi: 10.1038/aja.2010.15. Epub 2010 Apr 5. Review.

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