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Did you mean ca cancer (4,172,264 results)?
Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications.
Tataranni T, Piccoli C. Tataranni T, et al. Oxid Med Cell Longev. 2019 Nov 14;2019:8201079. doi: 10.1155/2019/8201079. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31827705 Free PMC article. Review.
The spread of reports supporting the efficiency of DCA in cancer therapy has prompted additional studies that let to find other potential molecular targets of DCA. Interestingly, DCA could significantly affect cancer stem cell fraction and contr …
The spread of reports supporting the efficiency of DCA in cancer therapy has prompted additional studies that let to find othe …
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.
Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N. Yoshimoto S, et al. Nature. 2013 Jul 4;499(7456):97-101. doi: 10.1038/nature12347. Epub 2013 Jun 26. Nature. 2013. PMID: 23803760
Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk factor for several common types of cancer. As the worldwide obesity epidemic has shown no signs of abating, better understanding of the m …
Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk fact …
Nomogram Predicts Risk and Prognostic Factors for Bone Metastasis of Pancreatic Cancer: A Population-Based Analysis.
Zhang W, Ji L, Wang X, Zhu S, Luo J, Zhang Y, Tong Y, Feng F, Kang Y, Bi Q. Zhang W, et al. Front Endocrinol (Lausanne). 2022 Mar 9;12:752176. doi: 10.3389/fendo.2021.752176. eCollection 2021. Front Endocrinol (Lausanne). 2022. PMID: 35356148 Free PMC article.
BACKGROUND: The overall survival (OS) of pancreatic cancer (PC) patients with bone metastasis (BM) is extremely low, and it is pretty hard to treat bone metastasis. ...Based on AUC of receiver operating characteristic (ROC) analysis, calibration plots, and decision curve a …
BACKGROUND: The overall survival (OS) of pancreatic cancer (PC) patients with bone metastasis (BM) is extremely low, and it is pretty …
The role of bile acids in carcinogenesis.
Režen T, Rozman D, Kovács T, Kovács P, Sipos A, Bai P, Mikó E. Režen T, et al. Cell Mol Life Sci. 2022 Apr 16;79(5):243. doi: 10.1007/s00018-022-04278-2. Cell Mol Life Sci. 2022. PMID: 35429253 Free PMC article. Review.
A small fraction of secondary and primary bile acids remains in the circulation and exert receptor-mediated and pure chemical effects (e.g. acidic bile in oesophageal cancer) on cancer cells. In this review, we assess how changes to bile acid biosynthesis, bile acid …
A small fraction of secondary and primary bile acids remains in the circulation and exert receptor-mediated and pure chemical effects (e.g. …
LASSO-Based Machine Learning Algorithm for Prediction of Lymph Node Metastasis in T1 Colorectal Cancer.
Kang J, Choi YJ, Kim IK, Lee HS, Kim H, Baik SH, Kim NK, Lee KY. Kang J, et al. Cancer Res Treat. 2021 Jul;53(3):773-783. doi: 10.4143/crt.2020.974. Epub 2020 Dec 29. Cancer Res Treat. 2021. PMID: 33421980 Free PMC article.
PURPOSE: The role of tumor-infiltrating lymphocytes (TILs) in predicting lymph node metastasis (LNM) in patients with T1 colorectal cancer (CRC) remains unclear. Furthermore, clinical utility of a machine learning-based approach has not been widely studied. ...The predicti …
PURPOSE: The role of tumor-infiltrating lymphocytes (TILs) in predicting lymph node metastasis (LNM) in patients with T1 colorectal cance …
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer.
Michelakis ED, Webster L, Mackey JR. Michelakis ED, et al. Br J Cancer. 2008 Oct 7;99(7):989-94. doi: 10.1038/sj.bjc.6604554. Epub 2008 Sep 2. Br J Cancer. 2008. PMID: 18766181 Free PMC article. Review.
The unique metabolism of most solid tumours (aerobic glycolysis, i.e., Warburg effect) is not only the basis of diagnosing cancer with metabolic imaging but might also be associated with the resistance to apoptosis that characterises cancer. The glycolytic phenotype …
The unique metabolism of most solid tumours (aerobic glycolysis, i.e., Warburg effect) is not only the basis of diagnosing cancer wit …
Reporting and Interpreting Decision Curve Analysis: A Guide for Investigators.
Van Calster B, Wynants L, Verbeek JFM, Verbakel JY, Christodoulou E, Vickers AJ, Roobol MJ, Steyerberg EW. Van Calster B, et al. Eur Urol. 2018 Dec;74(6):796-804. doi: 10.1016/j.eururo.2018.08.038. Epub 2018 Sep 19. Eur Urol. 2018. PMID: 30241973 Free PMC article. Review.
In contrast to traditional performance measures, decision curve analysis (DCA) can assess the utility of models for decision making. DCA plots net benefit (NB) at a range of clinically reasonable risk thresholds. OBJECTIVE: To provide recommendations on interpreting …
In contrast to traditional performance measures, decision curve analysis (DCA) can assess the utility of models for decision making. …
Development and validation of a radiomics-based nomogram for predicting a major pathological response to neoadjuvant immunochemotherapy for patients with potentially resectable non-small cell lung cancer.
Liu C, Zhao W, Xie J, Lin H, Hu X, Li C, Shang Y, Wang Y, Jiang Y, Ding M, Peng M, Xu T, Hu A, Huang Y, Gao Y, Liu X, Liu J, Ma F. Liu C, et al. Front Immunol. 2023 Feb 16;14:1115291. doi: 10.3389/fimmu.2023.1115291. eCollection 2023. Front Immunol. 2023. PMID: 36875128 Free PMC article. Clinical Trial.
INTRODUCTION: The treatment response to neoadjuvant immunochemotherapy varies among patients with potentially resectable non-small cell lung cancers (NSCLC) and may have severe immune-related adverse effects. ...RESULTS: The radiomics-clinical combined model achieved excel …
INTRODUCTION: The treatment response to neoadjuvant immunochemotherapy varies among patients with potentially resectable non-small cell lung …
Dichloroacetate and cancer: new home for an orphan drug?
Kankotia S, Stacpoole PW. Kankotia S, et al. Biochim Biophys Acta. 2014 Dec;1846(2):617-29. doi: 10.1016/j.bbcan.2014.08.005. Epub 2014 Aug 23. Biochim Biophys Acta. 2014. PMID: 25157892 Review.
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and congenital disorders of mitochondrial intermediary metabolism. ...These effects have been replicated in both human cancer cell lines …
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and …
Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium(I)-DCA conjugate.
Yang J, Cao Q, Zhang H, Hao L, Zhou D, Gan Z, Li Z, Tong YX, Ji LN, Mao ZW. Yang J, et al. Biomaterials. 2018 Sep;176:94-105. doi: 10.1016/j.biomaterials.2018.05.040. Epub 2018 May 25. Biomaterials. 2018. PMID: 29870900
We have developed a multi-functional Re-dca conjugate (Re-dca 2) by conjugating the metabolic modulator dichloroacetate (DCA) to mitochondria-targeted rhenium(I) complex, allowing its efficient penetration into cancer cells and selective accumulation i …
We have developed a multi-functional Re-dca conjugate (Re-dca 2) by conjugating the metabolic modulator dichloroacetate (DC …
3,225 results