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Results: 1 to 20 of 369

1.

Early-onset Parkinson's disease due to PINK1 p.Q456X mutation - Clinical and functional study.

Siuda J, Jasinska-Myga B, Boczarska-Jedynak M, Opala G, Fiesel FC, Moussaud-Lamodière EL, Scarffe LA, Dawson VL, Ross OA, Springer W, Dawson TM, Wszolek ZK.

Parkinsonism Relat Disord. 2014 Sep 2. pii: S1353-8020(14)00317-4. doi: 10.1016/j.parkreldis.2014.08.019. [Epub ahead of print]

PMID:
25226871
[PubMed - as supplied by publisher]
2.

Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder.

Lu W, Karuppagounder SS, Springer DA, Allen MD, Zheng L, Chao B, Zhang Y, Dawson VL, Dawson TM, Lenardo M.

Nat Commun. 2014 Sep 15;5:4930. doi: 10.1038/ncomms5930.

PMID:
25222142
[PubMed - in process]
3.

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.

Tsika E, Kannan M, Foo CS, Dikeman D, Glauser L, Gellhaar S, Galter D, Knott GW, Dawson TM, Dawson VL, Moore DJ.

Neurobiol Dis. 2014 Aug 29;71C:345-358. doi: 10.1016/j.nbd.2014.08.027. [Epub ahead of print]

PMID:
25174890
[PubMed - as supplied by publisher]
4.

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis.

Andrabi SA, Umanah GK, Chang C, Stevens DA, Karuppagounder SS, Gagné JP, Poirier GG, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10209-14. doi: 10.1073/pnas.1405158111. Epub 2014 Jul 1.

PMID:
24987120
[PubMed - in process]
5.

Proneural transcription factor Atoh1 drives highly efficient differentiation of human pluripotent stem cells into dopaminergic neurons.

Sagal J, Zhan X, Xu J, Tilghman J, Karuppagounder SS, Chen L, Dawson VL, Dawson TM, Laterra J, Ying M.

Stem Cells Transl Med. 2014 Aug;3(8):888-98. doi: 10.5966/sctm.2013-0213. Epub 2014 Jun 5.

PMID:
24904172
[PubMed - in process]
6.

Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins.

Chen YC, Umanah GK, Dephoure N, Andrabi SA, Gygi SP, Dawson TM, Dawson VL, Rutter J.

EMBO J. 2014 Jul 17;33(14):1548-64. doi: 10.15252/embj.201487943. Epub 2014 May 19.

PMID:
24843043
[PubMed - in process]
7.

The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease.

Karuppagounder SS, Brahmachari S, Lee Y, Dawson VL, Dawson TM, Ko HS.

Sci Rep. 2014 May 2;4:4874. doi: 10.1038/srep04874.

PMID:
24786396
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Botch is a γ-glutamyl cyclotransferase that deglycinates and antagonizes Notch.

Chi Z, Byrne ST, Dolinko A, Harraz MM, Kim MS, Umanah G, Zhong J, Chen R, Zhang J, Xu J, Chen L, Pandey A, Dawson TM, Dawson VL.

Cell Rep. 2014 May 8;7(3):681-8. doi: 10.1016/j.celrep.2014.03.048. Epub 2014 Apr 24.

PMID:
24767995
[PubMed - in process]
Free PMC Article
9.

Parkin and PINK1: much more than mitophagy.

Scarffe LA, Stevens DA, Dawson VL, Dawson TM.

Trends Neurosci. 2014 Jun;37(6):315-24. doi: 10.1016/j.tins.2014.03.004. Epub 2014 Apr 13. Review.

PMID:
24735649
[PubMed - in process]
10.

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.

Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, Dawson TM, Dawson VL.

Cell. 2014 Apr 10;157(2):472-85. doi: 10.1016/j.cell.2014.01.064.

PMID:
24725412
[PubMed - indexed for MEDLINE]
11.

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities.

Fatokun AA, Dawson VL, Dawson TM.

Br J Pharmacol. 2014 Apr;171(8):2000-16. doi: 10.1111/bph.12416.

PMID:
24684389
[PubMed - in process]
12.

A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.

Parkinson Study Group QE3 Investigators, Beal MF, Oakes D, Shoulson I, Henchcliffe C, Galpern WR, Haas R, Juncos JL, Nutt JG, Voss TS, Ravina B, Shults CM, Helles K, Snively V, Lew MF, Griebner B, Watts A, Gao S, Pourcher E, Bond L, Kompoliti K, Agarwal P, Sia C, Jog M, Cole L, Sultana M, Kurlan R, Richard I, Deeley C, Waters CH, Figueroa A, Arkun A, Brodsky M, Ondo WG, Hunter CB, Jimenez-Shahed J, Palao A, Miyasaki JM, So J, Tetrud J, Reys L, Smith K, Singer C, Blenke A, Russell DS, Cotto C, Friedman JH, Lannon M, Zhang L, Drasby E, Kumar R, Subramanian T, Ford DS, Grimes DA, Cote D, Conway J, Siderowf AD, Evatt ML, Sommerfeld B, Lieberman AN, Okun MS, Rodriguez RL, Merritt S, Swartz CL, Martin WR, King P, Stover N, Guthrie S, Watts RL, Ahmed A, Fernandez HH, Winters A, Mari Z, Dawson TM, Dunlop B, Feigin AS, Shannon B, Nirenberg MJ, Ogg M, Ellias SA, Thomas CA, Frei K, Bodis-Wollner I, Glazman S, Mayer T, Hauser RA, Pahwa R, Langhammer A, Ranawaya R, Derwent L, Sethi KD, Farrow B, Prakash R, Litvan I, Robinson A, Sahay A, Gartner M, Hinson VK, Markind S, Pelikan M, Perlmutter JS, Hartlein J, Molho E, Evans S, Adler CH, Duffy A, Lind M, Elmer L, Davis K, Spears J, Wilson S, Leehey MA, Hermanowicz N, Niswonger S, Shill HA, Obradov S, Rajput A, Cowper M, Lessig S, Song D, Fontaine D, Zadikoff C, Williams K, Blindauer KA, Bergholte J, Propsom CS, Stacy MA, Field J, Mihaila D, Chilton M, Uc EY, Sieren J, Simon DK, Kraics L, Silver A, Boyd JT, Hamill RW, Ingvoldstad C, Young J, Thomas K, Kostyk SK, Wojcieszek J, Pfeiffer RF, Panisset M, Beland M, Reich SG, Cines M, Zappala N, Rivest J, Zweig R, Lumina LP, Hilliard CL, Grill S, Kellermann M, Tuite P, Rolandelli S, Kang UJ, Young J, Rao J, Cook MM, Severt L, Boyar K.

JAMA Neurol. 2014 May;71(5):543-52. doi: 10.1001/jamaneurol.2014.131.

PMID:
24664227
[PubMed - indexed for MEDLINE]
13.

MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway.

Xiao J, Li Y, Prandovszky E, Karuppagounder SS, Talbot CC Jr, Dawson VL, Dawson TM, Yolken RH.

Neuroscience. 2014 May 30;268:128-38. doi: 10.1016/j.neuroscience.2014.03.015. Epub 2014 Mar 18.

PMID:
24657774
[PubMed - in process]
Free PMC Article
14.

Motor neuron death in ALS: programmed by astrocytes?

Pirooznia SK, Dawson VL, Dawson TM.

Neuron. 2014 Mar 5;81(5):961-3. doi: 10.1016/j.neuron.2014.02.024.

PMID:
24607221
[PubMed - indexed for MEDLINE]
15.

Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease.

Nuytemans K, Inchausti V, Beecham GW, Wang L, Dickson DW, Trojanowski JQ, Lee VM, Mash DC, Frosch MP, Foroud TM, Honig LS, Montine TJ, Dawson TM, Martin ER, Scott WK, Vance JM.

Mov Disord. 2014 May;29(6):827-30. doi: 10.1002/mds.25838. Epub 2014 Feb 26.

PMID:
24573903
[PubMed - in process]
16.

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.

Stafa K, Tsika E, Moser R, Musso A, Glauser L, Jones A, Biskup S, Xiong Y, Bandopadhyay R, Dawson VL, Dawson TM, Moore DJ.

Hum Mol Genet. 2014 Apr 15;23(8):2055-77. doi: 10.1093/hmg/ddt600. Epub 2013 Nov 26.

PMID:
24282027
[PubMed - in process]
Free PMC Article
17.

LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.

Migheli R, Del Giudice MG, Spissu Y, Sanna G, Xiong Y, Dawson TM, Dawson VL, Galioto M, Rocchitta G, Biosa A, Serra PA, Carri MT, Crosio C, Iaccarino C.

PLoS One. 2013 Oct 22;8(10):e77198. doi: 10.1371/journal.pone.0077198. eCollection 2013.

PMID:
24167564
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Protein microarray characterization of the S-nitrosoproteome.

Lee YI, Giovinazzo D, Kang HC, Lee Y, Jeong JS, Doulias PT, Xie Z, Hu J, Ghasemi M, Ischiropoulos H, Qian J, Zhu H, Blackshaw S, Dawson VL, Dawson TM.

Mol Cell Proteomics. 2014 Jan;13(1):63-72. doi: 10.1074/mcp.M113.032235. Epub 2013 Oct 8.

PMID:
24105792
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Usp16: key controller of stem cells in Down syndrome.

Xu JC, Dawson VL, Dawson TM.

EMBO J. 2013 Oct 30;32(21):2788-9. doi: 10.1038/emboj.2013.220. Epub 2013 Sep 27. No abstract available.

PMID:
24076652
[PubMed - indexed for MEDLINE]
20.

Parkin plays a role in sporadic Parkinson's disease.

Dawson TM, Dawson VL.

Neurodegener Dis. 2014;13(2-3):69-71. doi: 10.1159/000354307. Epub 2013 Sep 11.

PMID:
24029689
[PubMed - in process]

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