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Page 1
Dapsone Hydroxylamine, an Active Metabolite of Dapsone, Can Promote the Procoagulant Activity of Red Blood Cells and Thrombosis.
Bian Y, Kim K, An GJ, Ngo T, Bae ON, Lim KM, Chung JH. Bian Y, et al. Toxicol Sci. 2019 Dec 1;172(2):435-444. doi: 10.1093/toxsci/kfz188. Toxicol Sci. 2019. PMID: 31428780
Dapsone hydroxylamine (DDS-NHOH), N-hydroxylated metabolite of a sulfonamide antibiotic, dapsone, is responsible for various adverse effects of dapsone that include methemoglobinemia, hemolytic anemia, and thrombosis. ...Reactive oxygen species (ROS) generation and …
Dapsone hydroxylamine (DDS-NHOH), N-hydroxylated metabolite of a sulfonamide antibiotic, dapsone, is responsible for various a …
Role of dapsone hydroxylamine in dapsone-induced hemolytic anemia.
Grossman SJ, Jollow DJ. Grossman SJ, et al. J Pharmacol Exp Ther. 1988 Jan;244(1):118-25. J Pharmacol Exp Ther. 1988. PMID: 3335994
To determine whether the N-hydroxyarylamine metabolites of dapsone could be responsible for dapsone-induced hemolysis, dapsone, dapsone hydroxylamine (DDS-NOH) and monoacetyldapsone hydroxylamine were administered to rats which had previously received 51Cr-labeled r …
To determine whether the N-hydroxyarylamine metabolites of dapsone could be responsible for dapsone-induced hemolysis, dapsone, dapsone …
Dapsone hydroxylamine-mediated alterations in human red blood cells from endometriotic patients.
Andrisani A, Donà G, Sabbadin C, Dall'Acqua S, Tibaldi E, Roveri A, Bosello Travain V, Brunati AM, Ambrosini G, Ragazzi E, Armanini D, Bordin L. Andrisani A, et al. Gynecol Endocrinol. 2017 Dec;33(12):928-932. doi: 10.1080/09513590.2017.1332177. Epub 2017 May 30. Gynecol Endocrinol. 2017. PMID: 28557604
In endometriotic patients, RBC showed the highest level of oxidative-related alterations both in membrane and cytosol. More interestingly, the addition of dapsone hydroxylamine (DDS-NHOH) could induce further increase of both membranes and cytosol markers, with an e …
In endometriotic patients, RBC showed the highest level of oxidative-related alterations both in membrane and cytosol. More interestingly, t …
Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro.
Coleman MD, Jacobus DP. Coleman MD, et al. Biochem Pharmacol. 1993 Mar 9;45(5):1027-33. doi: 10.1016/0006-2952(93)90246-s. Biochem Pharmacol. 1993. PMID: 8461032
HPLC analysis revealed that parent amine was produced from dapsone hydroxylamine during methaemoglobin formation in the red cells. At 3 min, conversion of dapsone hydroxylamine to dapsone reached 7.0 +/- 3.9% leading to a maximum at 30 min (18.1 +/- 3. …
HPLC analysis revealed that parent amine was produced from dapsone hydroxylamine during methaemoglobin formation in the red ce …
Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro--II. Movement of dapsone across a semipermeable membrane into erythrocytes and plasma.
Coleman MD, Jacobus DP. Coleman MD, et al. Biochem Pharmacol. 1993 Oct 19;46(8):1363-8. doi: 10.1016/0006-2952(93)90100-b. Biochem Pharmacol. 1993. PMID: 8240384
Both diethyl dithiocarbamate (DDC) treated and untreated erythrocytes were incubated with dapsone hydroxylamine and dialysed against either fresh cells or plasma. ...
Both diethyl dithiocarbamate (DDC) treated and untreated erythrocytes were incubated with dapsone hydroxylamine and dialysed a …
Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro. III: Effect of diabetes.
Coleman MD, Simpson J, Jacobus DP. Coleman MD, et al. Biochem Pharmacol. 1994 Oct 7;48(7):1341-7. doi: 10.1016/0006-2952(94)90555-x. Biochem Pharmacol. 1994. PMID: 7945431
The fate of dapsone hydroxylamine has been investigated in diabetic and normal human erythrocytes. In erythrocytes from four type 1 (insulin dependent) diabetic subjects, there was a significant decrease in dapsone hydroxylamine-mediated methaemoglobin …
The fate of dapsone hydroxylamine has been investigated in diabetic and normal human erythrocytes. In erythrocytes from four t …
Dapsone-induced hemolytic anemia.
Jollow DJ, Bradshaw TP, McMillan DC. Jollow DJ, et al. Drug Metab Rev. 1995;27(1-2):107-24. doi: 10.3109/03602539509029818. Drug Metab Rev. 1995. PMID: 7641572 Review.
66 results