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Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model.
Fournet A, Rojas de Arias A, Ferreira ME, Nakayama H, Torres de Ortiz S, Schinini A, Samudio M, Vera de Bilbao N, Lavault M, Bonté F. Fournet A, et al. Int J Antimicrob Agents. 2000 Jan;13(3):189-95. doi: 10.1016/s0924-8579(99)00117-x. Int J Antimicrob Agents. 2000. PMID: 10724023
We have shown previously that daphnoline and cepharanthine are active against Trypanosoma cruzi and inhibited trypanothione reductase. ...Daphnoline showed the highest negative serological rate (48%). In chronically infected mice treated with daphnoline, we w …
We have shown previously that daphnoline and cepharanthine are active against Trypanosoma cruzi and inhibited trypanothione reductase …
Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase.
Fournet A, Inchausti A, Yaluff G, Rojas De Arias A, Guinaudeau H, Bruneton J, Breidenbach MA, Karplus PA, Faerman CH. Fournet A, et al. J Enzyme Inhib. 1998 Feb;13(1):1-9. doi: 10.3109/14756369809035823. J Enzyme Inhib. 1998. PMID: 9879510
The inhibitory activity of these compounds against trypanothione reductase (TR), a target enzyme for chemotherapy against Chagas disease, was also studied. Six BBIQ alkaloids (antioquine, cepharanthine, daphnoline, limacine, cycleanine and (-) curine) displayed a 50% letha …
The inhibitory activity of these compounds against trypanothione reductase (TR), a target enzyme for chemotherapy against Chagas disease, wa …
Traditional herbal compounds as candidates to inhibit the SARS-CoV-2 main protease: an in silico study.
de Oliveira OV, Cristina Andreazza Costa M, Marques da Costa R, Giordano Viegas R, Paluch AS, Miguel Castro Ferreira M. de Oliveira OV, et al. J Biomol Struct Dyn. 2023 Mar;41(5):1603-1616. doi: 10.1080/07391102.2021.2023646. Epub 2022 Jan 4. J Biomol Struct Dyn. 2023. PMID: 36719113
Among them, six molecules (physalin B 5,6-epoxide (PHY), methyl amentoflavone (MAM), withaphysalin C (WPC), daphnoline or trilobamine (TRI), cepharanoline (CEP) and tetrandrine (TET)) were selected based on Lipinski's rule and ADMET analysis as criteria. ...
Among them, six molecules (physalin B 5,6-epoxide (PHY), methyl amentoflavone (MAM), withaphysalin C (WPC), daphnoline or trilobamine …
(+)-Angchibangkine, a new type of bisbenzylisoquinoline alkaloid, and other dimers from Pachygone dasycarpa.
Guinaudeau H, Böhlke M, Lin LZ, Angerhofer CK, Cordell GA, RuangrungsiN. Guinaudeau H, et al. J Nat Prod. 1997 Mar;60(3):258-60. doi: 10.1021/np960568e. J Nat Prod. 1997. PMID: 9157192
Analysis of the alkaloidal fraction of the stem bark extract of Pachygone dasycarpa (Menispermaceae) resulted in the isolation of 10 known bisbenzylisoquinolines, (+)-tetrandrine, (+)-penduline, (+)-fangchinoline, (+)-atherospermoline, (+)-N-methyl-7-O-demethylpeinamine, (+)-d …
Analysis of the alkaloidal fraction of the stem bark extract of Pachygone dasycarpa (Menispermaceae) resulted in the isolation of 10 known b …