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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 1
1980 2
1987 1
1988 1
1990 1
1991 1
1992 2
1993 2
1994 2
1995 3
1996 3
1997 3
1998 6
1999 10
2000 8
2001 6
2002 5
2003 3
2004 14
2005 12
2006 15
2007 13
2008 19
2009 14
2010 15
2011 21
2012 20
2013 22
2014 30
2015 22
2016 17
2017 23
2018 24
2019 16
2020 28
2021 38
2022 33
2023 26
2024 12

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441 results

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Page 1
Structure and dynamics of GPCR signaling complexes.
Hilger D, Masureel M, Kobilka BK. Hilger D, et al. Nat Struct Mol Biol. 2018 Jan;25(1):4-12. doi: 10.1038/s41594-017-0011-7. Epub 2018 Jan 8. Nat Struct Mol Biol. 2018. PMID: 29323277 Free PMC article. Review.
G-protein-coupled receptors (GPCRs) relay numerous extracellular signals by triggering intracellular signaling through coupling with G proteins and arrestins. ...A full understanding of the molecular basis of GPCR-mediated signaling requires elucidation of the dynamics of …
G-protein-coupled receptors (GPCRs) relay numerous extracellular signals by triggering intracellular signaling through coupling with …
Current Aspects of the Role of Autoantibodies Directed Against Appetite-Regulating Hormones and the Gut Microbiome in Eating Disorders.
Smitka K, Prochazkova P, Roubalova R, Dvorak J, Papezova H, Hill M, Pokorny J, Kittnar O, Bilej M, Tlaskalova-Hogenova H. Smitka K, et al. Front Endocrinol (Lausanne). 2021 Apr 19;12:613983. doi: 10.3389/fendo.2021.613983. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 33953692 Free PMC article. Review.
Thus, the regulation of appetite, emotion, mood, and nutritional status is also under the control of neuroimmunoendocrine mechanisms by secretion of autoantibodies directed against neuropeptides, neuroactive metabolites, and peptides. In AN and BN, altered cholinerg …
Thus, the regulation of appetite, emotion, mood, and nutritional status is also under the control of neuroimmunoendocrine mech …
The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia.
Issa GC, Aldoss I, DiPersio J, Cuglievan B, Stone R, Arellano M, Thirman MJ, Patel MR, Dickens DS, Shenoy S, Shukla N, Kantarjian H, Armstrong SA, Perner F, Perry JA, Rosen G, Bagley RG, Meyers ML, Ordentlich P, Gu Y, Kumar V, Smith S, McGeehan GM, Stein EM. Issa GC, et al. Nature. 2023 Mar;615(7954):920-924. doi: 10.1038/s41586-023-05812-3. Epub 2023 Mar 15. Nature. 2023. PMID: 36922593 Free PMC article. Clinical Trial.
Targeting critical epigenetic regulators reverses aberrant transcription in cancer, thereby restoring normal tissue function(1-3). The interaction of menin with lysine methyltransferase 2A (KMT2A), an epigenetic regulator, is a dependence in acute leukaemia caused b …
Targeting critical epigenetic regulators reverses aberrant transcription in cancer, thereby restoring normal tissue function(1-3). Th …
Role of the gut-brain axis in energy and glucose metabolism.
Wachsmuth HR, Weninger SN, Duca FA. Wachsmuth HR, et al. Exp Mol Med. 2022 Apr;54(4):377-392. doi: 10.1038/s12276-021-00677-w. Epub 2022 Apr 26. Exp Mol Med. 2022. PMID: 35474341 Free PMC article. Review.
In addition, the enteric nervous system can act as a relay from the gut to the brain. The current review will outline the different gut-brain signaling mechanisms that contribute to metabolic homeostasis, highlighting the recent advances in understanding these compl …
In addition, the enteric nervous system can act as a relay from the gut to the brain. The current review will outline the diff …
Function of Renal Nerves in Kidney Physiology and Pathophysiology.
Osborn JW, Tyshynsky R, Vulchanova L. Osborn JW, et al. Annu Rev Physiol. 2021 Feb 10;83:429-450. doi: 10.1146/annurev-physiol-031620-091656. Annu Rev Physiol. 2021. PMID: 33566672 Review.
Renal sympathetic (efferent) nerves play an important role in the regulation of renal function, including glomerular filtration, sodium reabsorption, and renin release. ...In this review, we provide an overview of the current knowledge of the anatomy of efferent and …
Renal sympathetic (efferent) nerves play an important role in the regulation of renal function, including glomerular filtration, sodi …
MEN1 mutations mediate clinical resistance to menin inhibition.
Perner F, Stein EM, Wenge DV, Singh S, Kim J, Apazidis A, Rahnamoun H, Anand D, Marinaccio C, Hatton C, Wen Y, Stone RM, Schaller D, Mowla S, Xiao W, Gamlen HA, Stonestrom AJ, Persaud S, Ener E, Cutler JA, Doench JG, McGeehan GM, Volkamer A, Chodera JD, Nowak RP, Fischer ES, Levine RL, Armstrong SA, Cai SF. Perner F, et al. Nature. 2023 Mar;615(7954):913-919. doi: 10.1038/s41586-023-05755-9. Epub 2023 Mar 15. Nature. 2023. PMID: 36922589 Free PMC article. Clinical Trial.
Chromatin-binding proteins are critical regulators of cell state in haematopoiesis(1,2). Acute leukaemias driven by rearrangement of the mixed lineage leukaemia 1 gene (KMT2Ar) or mutation of the nucleophosmin gene (NPM1) require the chromatin adapter protein menin, encode …
Chromatin-binding proteins are critical regulators of cell state in haematopoiesis(1,2). Acute leukaemias driven by rearrangement of …
Neuroanatomy, Thalamus.
Torrico TJ, Munakomi S. Torrico TJ, et al. 2023 Jul 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jul 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31194341 Free Books & Documents.
The thalamus is composed of different nuclei that each serve a unique role, ranging from relaying sensory and motor signals, as well as regulation of consciousness and alertness. ...Surgical interventions of the thalamus in the past have had limitations, but curr …
The thalamus is composed of different nuclei that each serve a unique role, ranging from relaying sensory and motor signals, as well …
Next-generation selective estrogen receptor degraders and other novel endocrine therapies for management of metastatic hormone receptor-positive breast cancer: current and emerging role.
Lloyd MR, Wander SA, Hamilton E, Razavi P, Bardia A. Lloyd MR, et al. Ther Adv Med Oncol. 2022 Jul 30;14:17588359221113694. doi: 10.1177/17588359221113694. eCollection 2022. Ther Adv Med Oncol. 2022. PMID: 35923930 Free PMC article. Review.
ET resistance can be driven by ligand-independent, ER-mediated signaling that promotes tumor proliferation in the absence of hormone, or ER-independent oncogenic signaling that circumvents endocrine regulated transcription pathways. Estrogen receptor 1 (ESR1) mutations ind …
ET resistance can be driven by ligand-independent, ER-mediated signaling that promotes tumor proliferation in the absence of hormone, or ER- …
Pembrolizumab monotherapy versus chemotherapy in platinum-pretreated, recurrent or metastatic nasopharyngeal cancer (KEYNOTE-122): an open-label, randomized, phase III trial.
Chan ATC, Lee VHF, Hong RL, Ahn MJ, Chong WQ, Kim SB, Ho GF, Caguioa PB, Ngamphaiboon N, Ho C, Aziz MASA, Ng QS, Yen CJ, Soparattanapaisarn N, Ngan RK, Kho SK, Tiambeng MLA, Yun T, Sriuranpong V, Algazi AP, Cheng A, Massarelli E, Swaby RF, Saraf S, Yuan J, Siu LL. Chan ATC, et al. Ann Oncol. 2023 Mar;34(3):251-261. doi: 10.1016/j.annonc.2022.12.007. Epub 2022 Dec 16. Ann Oncol. 2023. PMID: 36535566 Free article. Clinical Trial.
Ras-Mediated Activation of the Raf Family Kinases.
Terrell EM, Morrison DK. Terrell EM, et al. Cold Spring Harb Perspect Med. 2019 Jan 2;9(1):a033746. doi: 10.1101/cshperspect.a033746. Cold Spring Harb Perspect Med. 2019. PMID: 29358316 Free PMC article. Review.
The extracellular signal-regulated kinase (ERK) cascade comprised of the Raf, MEK, and ERK protein kinases constitutes a key effector cascade used by the Ras GTPases to relay signals regulating cell growth, survival, proliferation, and differentiation. Of the …
The extracellular signal-regulated kinase (ERK) cascade comprised of the Raf, MEK, and ERK protein kinases constitutes a key effector …
441 results