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Tropomyosin Receptor Antagonism in Cylindromatosis (TRAC), an early phase trial of a topical tropomyosin kinase inhibitor as a treatment for inherited CYLD defective skin tumours: study protocol for a randomised controlled trial.
Cranston A, Stocken DD, Stamp E, Roblin D, Hamlin J, Langtry J, Plummer R, Ashworth A, Burn J, Rajan N. Cranston A, et al. Trials. 2017 Mar 7;18(1):111. doi: 10.1186/s13063-017-1812-z. Trials. 2017. PMID: 28270164 Free PMC article. Clinical Trial.
Recently, the development of an ointment containing a TRK inhibitor (pegcantratinib - previously CT327 - from Creabilis SA) allowed for the assessment of TRK inhibition in tumours from patients with inherited CYLD mutations. ...
Recently, the development of an ointment containing a TRK inhibitor (pegcantratinib - previously CT327 - from Creabilis SA) allowed f …
Topical TrkA Kinase Inhibitor CT327 is an Effective, Novel Therapy for the Treatment of Pruritus due to Psoriasis: Results from Experimental Studies, and Efficacy and Safety of CT327 in a Phase 2b Clinical Trial in Patients with Psoriasis.
Roblin D, Yosipovitch G, Boyce B, Robinson J, Sandy J, Mainero V, Wickramasinghe R, Anand U, Anand P. Roblin D, et al. Acta Derm Venereol. 2015 May;95(5):542-8. doi: 10.2340/00015555-2047. Acta Derm Venereol. 2015. PMID: 25594427 Free article. Clinical Trial.