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Items: 1 to 20 of 28


Cortical PGC-1α-Dependent Transcripts are Reduced in Postmortem Tissue From Patients With Schizophrenia.

McMeekin LJ, Lucas EK, Meador-Woodruff JH, McCullumsmith RE, Hendrickson RC, Gamble KL, Cowell RM.

Schizophr Bull. 2015 Dec 17. pii: sbv184. [Epub ahead of print]


Interneuron Transcriptional Dysregulation Causes Frequency-Dependent Alterations in the Balance of Inhibition and Excitation in Hippocampus.

Bartley AF, Lucas EK, Brady LJ, Li Q, Hablitz JJ, Cowell RM, Dobrunz LE.

J Neurosci. 2015 Nov 18;35(46):15276-90. doi: 10.1523/JNEUROSCI.1834-15.2015.


Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α.

Lucas EK, Reid CS, McMeekin LJ, Dougherty SE, Floyd CL, Cowell RM.

Front Cell Neurosci. 2015 Jan 6;8:441. doi: 10.3389/fncel.2014.00441. eCollection 2014.


PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons.

Lucas EK, Dougherty SE, McMeekin LJ, Reid CS, Dobrunz LE, West AB, Hablitz JJ, Cowell RM.

J Neurosci. 2014 Oct 22;34(43):14375-87. doi: 10.1523/JNEUROSCI.1222-14.2014.


Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex.

Dougherty SE, Bartley AF, Lucas EK, Hablitz JJ, Dobrunz LE, Cowell RM.

Neuroscience. 2014 Jun 20;271:137-48. doi: 10.1016/j.neuroscience.2014.04.023. Epub 2014 Apr 24.


Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.

West AB, Cowell RM, Daher JP, Moehle MS, Hinkle KM, Melrose HL, Standaert DG, Volpicelli-Daley LA.

J Comp Neurol. 2014 Aug 1;522(11):2465-80. doi: 10.1002/cne.23583. Epub 2014 Apr 12.


Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells.

Dougherty SE, Hollimon JJ, McMeekin LJ, Bohannon AS, West AB, Lesort M, Hablitz JJ, Cowell RM.

Neurobiol Dis. 2014 Feb;62:160-71. doi: 10.1016/j.nbd.2013.10.002. Epub 2013 Oct 11.


Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophrenia.

Jiang Z, Cowell RM, Nakazawa K.

Front Behav Neurosci. 2013 Sep 3;7:116. doi: 10.3389/fnbeh.2013.00116. Review.


LRRK2 secretion in exosomes is regulated by 14-3-3.

Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY, Stewart CA, Yacoubian TA, Cowell RM, Dokland T, Ye T, Chen D, Siegal GP, Galemmo RA, Tsika E, Moore DJ, Standaert DG, Kojima K, Mobley JA, West AB.

Hum Mol Genet. 2013 Dec 15;22(24):4988-5000. doi: 10.1093/hmg/ddt346. Epub 2013 Jul 25.


Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies.

Davies P, Hinkle KM, Sukar NN, Sepulveda B, Mesias R, Serrano G, Alessi DR, Beach TG, Benson DL, White CL, Cowell RM, Das SS, West AB, Melrose HL.

Biochem J. 2013 Jul 1;453(1):101-13. doi: 10.1042/BJ20121742.


Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneurons.

Jiang Z, Rompala GR, Zhang S, Cowell RM, Nakazawa K.

Biol Psychiatry. 2013 May 15;73(10):1024-34. doi: 10.1016/j.biopsych.2012.12.004. Epub 2013 Jan 21.


Purkinje cell dysfunction and loss in a knock-in mouse model of Huntington disease.

Dougherty SE, Reeves JL, Lesort M, Detloff PJ, Cowell RM.

Exp Neurol. 2013 Feb;240:96-102. doi: 10.1016/j.expneurol.2012.11.015. Epub 2012 Nov 26.


Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking pgc-1α.

Lucas EK, Dougherty SE, McMeekin LJ, Trinh AT, Reid CS, Cowell RM.

PLoS One. 2012;7(8):e42878. doi: 10.1371/journal.pone.0042878. Epub 2012 Aug 14.


Disruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington disease.

Dougherty SE, Reeves JL, Lucas EK, Gamble KL, Lesort M, Cowell RM.

Exp Neurol. 2012 Jul;236(1):171-8. doi: 10.1016/j.expneurol.2012.04.015. Epub 2012 May 2.


LRRK2 inhibition attenuates microglial inflammatory responses.

Moehle MS, Webber PJ, Tse T, Sukar N, Standaert DG, DeSilva TM, Cowell RM, West AB.

J Neurosci. 2012 Feb 1;32(5):1602-11. doi: 10.1523/JNEUROSCI.5601-11.2012.


Neuronal inactivation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protects mice from diet-induced obesity and leads to degenerative lesions.

Ma D, Li S, Lucas EK, Cowell RM, Lin JD.

J Biol Chem. 2010 Dec 10;285(50):39087-95. doi: 10.1074/jbc.M110.151688. Epub 2010 Oct 13.


Parvalbumin deficiency and GABAergic dysfunction in mice lacking PGC-1alpha.

Lucas EK, Markwardt SJ, Gupta S, Meador-Woodruff JH, Lin JD, Overstreet-Wadiche L, Cowell RM.

J Neurosci. 2010 May 26;30(21):7227-35. doi: 10.1523/JNEUROSCI.0698-10.2010.


Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells.

Cowell RM, Talati P, Blake KR, Meador-Woodruff JH, Russell JW.

Biochem Biophys Res Commun. 2009 Feb 6;379(2):578-82. doi: 10.1016/j.bbrc.2008.12.109. Epub 2008 Dec 30.


Regulation of PGC-1alpha and PGC-1alpha-responsive genes with forskolin-induced Schwann cell differentiation.

Cowell RM, Blake KR, Inoue T, Russell JW.

Neurosci Lett. 2008 Jul 18;439(3):269-74. doi: 10.1016/j.neulet.2008.04.104. Epub 2008 May 16.

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