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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1968 1
1969 1
1972 3
1973 2
1974 5
1975 3
1976 4
1977 6
1978 3
1979 5
1980 6
1981 6
1982 15
1983 18
1984 27
1985 32
1986 34
1987 34
1988 37
1989 45
1990 65
1991 74
1992 77
1993 78
1994 112
1995 112
1996 105
1997 156
1998 152
1999 142
2000 186
2001 195
2002 163
2003 168
2004 214
2005 197
2006 231
2007 267
2008 270
2009 232
2010 282
2011 301
2012 297
2013 362
2014 345
2015 309
2016 316
2017 271
2018 308
2019 317
2020 319
2021 325
2022 349
2023 273
2024 130

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7,329 results

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Page 1
Creation of a bacterial cell controlled by a chemically synthesized genome.
Gibson DG, Glass JI, Lartigue C, Noskov VN, Chuang RY, Algire MA, Benders GA, Montague MG, Ma L, Moodie MM, Merryman C, Vashee S, Krishnakumar R, Assad-Garcia N, Andrews-Pfannkoch C, Denisova EA, Young L, Qi ZQ, Segall-Shapiro TH, Calvey CH, Parmar PP, Hutchison CA 3rd, Smith HO, Venter JC. Gibson DG, et al. Science. 2010 Jul 2;329(5987):52-6. doi: 10.1126/science.1190719. Epub 2010 May 20. Science. 2010. PMID: 20488990
We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are contr …
We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized geno …
Role of PFKFB3-driven glycolysis in vessel sprouting.
De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P. De Bock K, et al. Cell. 2013 Aug 1;154(3):651-63. doi: 10.1016/j.cell.2013.06.037. Cell. 2013. PMID: 23911327 Free article.
Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled by genetic signals (such as Notch), but it is unknown whether metabolism also regulates this process. ...Mechanistically, PFKFB3 not only regulated EC proliferation but also …
Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled by genetic signals (such as Notch), b …
Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder.
Patke A, Murphy PJ, Onat OE, Krieger AC, Özçelik T, Campbell SS, Young MW. Patke A, et al. Cell. 2017 Apr 6;169(2):203-215.e13. doi: 10.1016/j.cell.2017.03.027. Cell. 2017. PMID: 28388406 Free PMC article.
Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes 24 hr rhythms in many behavioral and physiological processes. ...Here, we report a hereditary form of DSPD associated with a dominant coding variation in the core circadian clock …
Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes 24 hr rhythms in many behavioral and ph …
Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase.
Pellegrini M, Claps G, Orlova VV, Barrios F, Dolci S, Geremia R, Rossi P, Rossi G, Arnold B, Chavakis T, Feigenbaum L, Sharan SK, Nussenzweig A. Pellegrini M, et al. J Cell Sci. 2011 Jan 1;124(Pt 1):91-9. doi: 10.1242/jcs.072959. Epub 2010 Dec 8. J Cell Sci. 2011. PMID: 21147852 Free PMC article.
A strong reduction of Nbs1 and JAM-C protein levels was found in the testis. Although Nbs1-deleted mice developed minor gonadal abnormalities, JAM-C-knockout mice showed a spermiogenetic arrest, as previously described for the null mice. These results provide strong eviden …
A strong reduction of Nbs1 and JAM-C protein levels was found in the testis. Although Nbs1-deleted mice developed minor gonadal abnor …
Generating endogenous Myh11-driven Cre mice for sex-independent gene deletion in smooth muscle cells.
Zhao Y, Zhao G, Chang Z, Zhu T, Zhao Y, Lu H, Xue C, Saunders TL, Guo Y, Chang L, Chen YE, Zhang J. Zhao Y, et al. JCI Insight. 2023 Jul 24;8(14):e171661. doi: 10.1172/jci.insight.171661. JCI Insight. 2023. PMID: 37289544 Free PMC article.
Specific and efficient smooth muscle cell-targeted (SMC-targeted) gene deletion is typically achieved by pairing SMMHC-CreERT2-Tg mice with mice carrying the loxP-flanked gene. However, the transgene, CreERT2, is not controlled by the endogenous Myh11 …
Specific and efficient smooth muscle cell-targeted (SMC-targeted) gene deletion is typically achieved by pairing SMMHC-CreERT2 …
dnm1 deletion blocks mitochondrial fragmentation in deltafzo1 cells.
Yang Y, Hu Y, Wu L, Zhang P, Shang J. Yang Y, et al. Yeast. 2021 Mar;38(3):197-205. doi: 10.1002/yea.3524. Epub 2021 Feb 4. Yeast. 2021. PMID: 33125774
Here, we report the characterization of the Schizosaccharomyces pombe homologue of S. cerevisiae Fzo1p, Fzo1. Disruption of the fzo1 gene in S. pombe results in a fragmented mitochondrial morphology and a dramatically reduced growth on glycerol medium phenotype, indicating …
Here, we report the characterization of the Schizosaccharomyces pombe homologue of S. cerevisiae Fzo1p, Fzo1. Disruption of the fzo1 gene …
EZH2 deletion promotes spermatogonial differentiation and apoptosis.
Jin C, Zhang Y, Wang ZP, Wang XX, Sun TC, Li XY, Tang JX, Cheng JM, Li J, Chen SR, Deng SL, Liu YX. Jin C, et al. Reproduction. 2017 Nov;154(5):615-625. doi: 10.1530/REP-17-0302. Reproduction. 2017. PMID: 28982932
Spermatogenesis is crucial for male fertility and is therefore tightly controlled by a variety of epigenetic regulators. However, the function of enhancer of zeste homolog 2 (EZH2) in spermatogenesis and the molecular mechanisms underlying its activity remain poorly define …
Spermatogenesis is crucial for male fertility and is therefore tightly controlled by a variety of epigenetic regulators. However, the …
Effects of mokF gene deletion and overexpression on the Monacolin K metabolism yields of Monascus purpureus.
Zhang C, Chen M, Yang L, Cheng Y, Qin Y, Zang Y, Wang B, Sun B, Wang C. Zhang C, et al. Appl Microbiol Biotechnol. 2022 Apr;106(8):3069-3080. doi: 10.1007/s00253-022-11913-2. Epub 2022 Apr 18. Appl Microbiol Biotechnol. 2022. PMID: 35435455
Overall, our study verified the function of mokF in M. purpureus using gene deletion and overexpression technology. KEY POINTS: The deletion and overexpression strains of mokF gene were successfully constructed. The deletion or overexpression of …
Overall, our study verified the function of mokF in M. purpureus using gene deletion and overexpression technology. KEY POINTS …
DiCre-Based Inducible Gene Expression.
Damasceno JD, Tosi LRO, Santos RERS, Mottram JC. Damasceno JD, et al. Methods Mol Biol. 2019;1971:225-235. doi: 10.1007/978-1-4939-9210-2_11. Methods Mol Biol. 2019. PMID: 30980306
Induction of gene expression is a valuable approach for functional studies since it allows for the assessment of phenotypes without the need for clonal selection. ...Here, we describe a detailed protocol for the use of the DiCre-based inducible gene expression syste …
Induction of gene expression is a valuable approach for functional studies since it allows for the assessment of phenotypes without t …
Fully Attenuated meq and pp38 Double Gene Deletion Mutant Virus Confers Superior Immunological Protection against Highly Virulent Marek's Disease Virus Infection.
Sun A, Zhao X, Zhu X, Kong Z, Liao Y, Teng M, Yao Y, Luo J, Nair V, Zhuang G, Zhang G. Sun A, et al. Microbiol Spectr. 2022 Dec 21;10(6):e0287122. doi: 10.1128/spectrum.02871-22. Epub 2022 Nov 9. Microbiol Spectr. 2022. PMID: 36350141 Free PMC article.
To overcome this deficiency and produce more vaccine candidates, a recombinant MDV was generated from the highly virulent Md5BAC strain, in which both meq and a cytolytic replication-related gene, pp38, were deleted. Replication of the double deletion virus, …
To overcome this deficiency and produce more vaccine candidates, a recombinant MDV was generated from the highly virulent Md5BAC strain, in …
7,329 results