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Complement system in lung transplantation.
Ali HA, Pavlisko EN, Snyder LD, Frank M, Palmer SM. Ali HA, et al. Clin Transplant. 2018 Apr;32(4):e13208. doi: 10.1111/ctr.13208. Epub 2018 Feb 14. Clin Transplant. 2018. PMID: 29374425 Review.
The complement system is a cascade of multiple proteins that have been known to mediate inflammatory response. ...The complement cascade appears to have a prominent role in mediating lung allograft damage in the setting of ischemia-reperfusio …
The complement system is a cascade of multiple proteins that have been known to mediate inflammatory response. ...The …
IL-1beta-dependent extravasation of preexisting lung-restricted autoantibodies during lung transplantation activates complement and mediates primary graft dysfunction.
Yang W, Cerier EJ, Núñez-Santana FL, Wu Q, Yan Y, Kurihara C, Liu X, Yeldandi A, Khurram N, Avella-Patino D, Sun H, Budinger GRS, Kreisel D, Mohanakumar T, Lecuona E, Bharat A. Yang W, et al. J Clin Invest. 2022 Oct 17;132(20):e157975. doi: 10.1172/JCI157975. J Clin Invest. 2022. PMID: 36250462 Free PMC article.
Whole LRA IgG molecules were necessary for lung injury, which was mediated by the classical and alternative complement pathways and reversed by complement inhibition. ...We conclude that preexisting LRAs can compound ischemia-reperfusion inju …
Whole LRA IgG molecules were necessary for lung injury, which was mediated by the classical and alternative complement …
sCR1sLe ameliorates ischemia/reperfusion injury in experimental lung transplantation.
Stammberger U, Hamacher J, Hillinger S, Schmid RA. Stammberger U, et al. J Thorac Cardiovasc Surg. 2000 Dec;120(6):1078-84. doi: 10.1067/mtc.2000.111175. J Thorac Cardiovasc Surg. 2000. PMID: 11088029 Free article.
BACKGROUND: The nonspecific immune response with activation of the complement system and polymorphonuclear leukocytes is important for the mediation of reperfusion injury after lung transplantation. ...CONCLUSIONS: Our data indicate that …
BACKGROUND: The nonspecific immune response with activation of the complement system and polymorphonuclear leukocytes is impor …
Increasing the efficacy and safety of a human complement inhibitor for treating post-transplant cardiac ischemia reperfusion injury by targeting to a graft-specific neoepitope.
Zheng C, Sleiman MM, Yang X, He S, Atkinson C, Tomlinson S. Zheng C, et al. J Heart Lung Transplant. 2021 Oct;40(10):1112-1121. doi: 10.1016/j.healun.2021.07.004. Epub 2021 Jul 12. J Heart Lung Transplant. 2021. PMID: 34334299 Free PMC article.
BACKGROUND: Post-transplant ischemia reperfusion injury (IRI) is a recognized risk factor for subsequent organ dysfunction, alloresponsiveness, and rejection. The complement system is known to play a role in IRI and represents a therapeutic target. ...
BACKGROUND: Post-transplant ischemia reperfusion injury (IRI) is a recognized risk factor for subsequent organ dysfunction, al …
Emphysema-associated Autoreactive Antibodies Exacerbate Post-Lung Transplant Ischemia-Reperfusion Injury.
Patel KJ, Cheng Q, Stephenson S, Allen DP, Li C, Kilkenny J, Finnegan R, Montalvo-Calero V, Esckilsen S, Vasu C, Goddard M, Nadig SN, Atkinson C. Patel KJ, et al. Am J Respir Cell Mol Biol. 2019 Jun;60(6):678-686. doi: 10.1165/rcmb.2018-0224OC. Am J Respir Cell Mol Biol. 2019. PMID: 30571141 Free PMC article.
Chronic obstructive pulmonary disease-associated chronic inflammation has been shown to lead to an autoimmune phenotype characterized in part by the presence of lung autoreactive antibodies. We hypothesized that ischemia-reperfusion injury (IRI) liberates epi …
Chronic obstructive pulmonary disease-associated chronic inflammation has been shown to lead to an autoimmune phenotype characterized in par …
Local complement activation is associated with primary graft dysfunction after lung transplantation.
Kulkarni HS, Ramphal K, Ma L, Brown M, Oyster M, Speckhart KN, Takahashi T, Byers DE, Porteous MK, Kalman L, Hachem RR, Rushefski M, McPhatter J, Cano M, Kreisel D, Scavuzzo M, Mittler B, Cantu E 3rd, Pilely K, Garred P, Christie JD, Atkinson JP, Gelman AE, Diamond JM. Kulkarni HS, et al. JCI Insight. 2020 Sep 3;5(17):e138358. doi: 10.1172/jci.insight.138358. JCI Insight. 2020. PMID: 32750037 Free PMC article.
BACKGROUNDThe complement system plays a key role in host defense but is activated by ischemia/reperfusion injury (IRI). Primary graft dysfunction (PGD) is a form of acute lung injury occurring predominantly due to IRI, which worsens survi …
BACKGROUNDThe complement system plays a key role in host defense but is activated by ischemia/reperfusion injury …
C1-esterase inhibitor reduces reperfusion injury after lung transplantation.
Scherer M, Demertzis S, Langer F, Moritz A, Schäfers HJ. Scherer M, et al. Ann Thorac Surg. 2002 Jan;73(1):233-8; discussion 238-9. doi: 10.1016/s0003-4975(01)03235-0. Ann Thorac Surg. 2002. PMID: 11834015
BACKGROUND: Activation of the complement system and polymorphonuclear neutrophilic leukocytes plays a major role in mediating reperfusion injury after lung transplantation. We hypothesized that early interference with complement ac …
BACKGROUND: Activation of the complement system and polymorphonuclear neutrophilic leukocytes plays a major role in mediating …
Complement-dependent NADPH oxidase enzyme activation in renal ischemia/reperfusion injury.
Simone S, Rascio F, Castellano G, Divella C, Chieti A, Ditonno P, Battaglia M, Crovace A, Staffieri F, Oortwijn B, Stallone G, Gesualdo L, Pertosa G, Grandaliano G. Simone S, et al. Free Radic Biol Med. 2014 Sep;74:263-73. doi: 10.1016/j.freeradbiomed.2014.07.003. Epub 2014 Jul 10. Free Radic Biol Med. 2014. PMID: 25017967
NADPH oxidase plays a central role in mediating oxidative stress during heart, liver, and lung ischemia/reperfusion injury, but limited information is available about NADPH oxidase in renal ischemia/reperfusion injury. ...In conclusion, our find …
NADPH oxidase plays a central role in mediating oxidative stress during heart, liver, and lung ischemia/reperfusion injury …
A randomized, placebo-controlled trial of complement inhibition in ischemia-reperfusion injury after lung transplantation in human beings.
Keshavjee S, Davis RD, Zamora MR, de Perrot M, Patterson GA. Keshavjee S, et al. J Thorac Cardiovasc Surg. 2005 Feb;129(2):423-8. doi: 10.1016/j.jtcvs.2004.06.048. J Thorac Cardiovasc Surg. 2005. PMID: 15678055 Free article. Clinical Trial.
OBJECTIVE: Complement activation has been shown to play a significant role in ischemia-reperfusion injury after lung transplantation. ...This was a clinical trial of TP-10 to reduce ischemia-reperfusion injury in lung tra …
OBJECTIVE: Complement activation has been shown to play a significant role in ischemia-reperfusion injury after lung …
Effect of soluble complement receptor type 1 on reperfusion edema and neutrophil migration after lung allotransplantation in swine.
Schmid RA, Zollinger A, Singer T, Hillinger S, Leon-Wyss JR, Schöb OM, Høgåsen K, Zünd G, Patterson GA, Weder W. Schmid RA, et al. J Thorac Cardiovasc Surg. 1998 Jul;116(1):90-7. doi: 10.1016/S0022-5223(98)70246-6. J Thorac Cardiovasc Surg. 1998. PMID: 9671902 Free article.
We evaluated the effect of soluble complement receptor type 1 on lung allograft reperfusion injury. METHODS: Left lung transplantation was performed in 13 weight-matched pigs (25 to 31 kg) after prolonged preservation (20 hours at 1 degre …
We evaluated the effect of soluble complement receptor type 1 on lung allograft reperfusion injury. METHODS: Lef …
34 results