Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1995 1
2002 2
2005 2
2006 4
2007 2
2010 1
2011 1
2012 3
2013 1
2015 1
2016 2
2017 2
2020 2
2021 2
2022 3
2023 4
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

27 results

Results by year

Filters applied: . Clear all
Page 1
Did you mean columbia (351,220 results)?
Cytochrome P450 Enzyme-Mediated Bioactivation as an Underlying Mechanism of Columbin-Induced Hepatotoxicity.
Pei J, Xiao W, Zhu D, Ji X, Shi L, Deng X. Pei J, et al. Chem Res Toxicol. 2020 Apr 20;33(4):940-947. doi: 10.1021/acs.chemrestox.9b00486. Epub 2020 Mar 20. Chem Res Toxicol. 2020. PMID: 32162908
Columbin, a furanoid compound, is the major bioactive ingredient of Tinospora sagittata (Oliv.) ...The aim of this study was to investigate the hepatotoxicity caused by columbin and its underlying mechanism. Our results indicated that columbin could result in …
Columbin, a furanoid compound, is the major bioactive ingredient of Tinospora sagittata (Oliv.) ...The aim of this study was to inves …
Columbin inhibits cholesterol uptake in bloodstream forms of Trypanosoma brucei-A possible trypanocidal mechanism.
Nok AJ, Sallau BA, Onyike E, Useh NM. Nok AJ, et al. J Enzyme Inhib Med Chem. 2005 Aug;20(4):365-8. doi: 10.1080/14756360400028127. J Enzyme Inhib Med Chem. 2005. PMID: 16206831
The diterpenoid furanolactone (columbin) from Aristolochia albida inhibited growth of culture forms of Trypanosoma brucei. ...However, columbin could not clear parasites in the cerebrospinal fluid....
The diterpenoid furanolactone (columbin) from Aristolochia albida inhibited growth of culture forms of Trypanosoma brucei. ...However …
Semisynthesis and Kappa-Opioid Receptor Activity of Derivatives of Columbin, a Furanolactone Diterpene.
Yilmaz A, Crowley RS, Sherwood AM, Prisinzano TE. Yilmaz A, et al. J Nat Prod. 2017 Jul 28;80(7):2094-2100. doi: 10.1021/acs.jnatprod.7b00327. Epub 2017 Jul 18. J Nat Prod. 2017. PMID: 28718638 Free PMC article.
Columbin (1) is a furanolactone diterpene isolated from the roots of Jateorhiza and Tinospora species. ...This work represents not only the first evaluation of columbin (1) at the KOR but also one of the first works to explore synthetic strategies that are tolerated …
Columbin (1) is a furanolactone diterpene isolated from the roots of Jateorhiza and Tinospora species. ...This work represents not on …
In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-kappaB translocation.
Ibrahim Abdelwahab S, Syaed Koko W, Mohamed Elhassan Taha M, Mohan S, Achoui M, Ameen Abdulla M, Rais Mustafa M, Ahmad S, Ibrahim Noordin M, Lip Yong C, Roslan Sulaiman M, Othman R, Amir Hassan A. Ibrahim Abdelwahab S, et al. Eur J Pharmacol. 2012 Mar 5;678(1-3):61-70. doi: 10.1016/j.ejphar.2011.12.024. Epub 2011 Dec 27. Eur J Pharmacol. 2012. PMID: 22227329
The anti-inflammatory effects of columbin were studied in vitro, in silico and in vivo. The effect of columbin on nitric oxide was examined on lipopolysaccharide-interferon-gamma (LPS/IFN) induced RAW264.7 macrophages. ...This study presents columbin as a pot …
The anti-inflammatory effects of columbin were studied in vitro, in silico and in vivo. The effect of columbin on nitric oxide …
DNA damage and up-regulation of PARP-1 induced by columbin in vitro and in vivo.
Liao Y, Wang X, Ran G, Zhang S, Wu C, Tan R, Liu Y, He Y, Liu T, Wu Z, Peng Y, Li W, Zheng J. Liao Y, et al. Toxicol Lett. 2023 Apr 15;379:20-34. doi: 10.1016/j.toxlet.2023.03.003. Epub 2023 Mar 10. Toxicol Lett. 2023. PMID: 36905973
Columbin (CLB) is the most abundant (>1.0%) furan-containing diterpenoid lactone in herbal medicine Tinospora sagittate (Oliv.) ...
Columbin (CLB) is the most abundant (>1.0%) furan-containing diterpenoid lactone in herbal medicine Tinospora sagittate (Oliv.) .. …
A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis.
Kohno H, Maeda M, Tanino M, Tsukio Y, Ueda N, Wada K, Sugie S, Mori H, Tanaka T. Kohno H, et al. Cancer Lett. 2002 Sep 26;183(2):131-9. doi: 10.1016/s0304-3835(02)00159-3. Cancer Lett. 2002. PMID: 12065087
Animals were initiated with AOM (three weekly subcutaneous injections of 15 mg/kg body weight) to induce colonic neoplasms. They were fed the experimental diets mixed with columbin (4, 20, and 100 ppm) for 4 weeks, starting 1 week before the first dosing of AOM and thereaf …
Animals were initiated with AOM (three weekly subcutaneous injections of 15 mg/kg body weight) to induce colonic neoplasms. They were fed th …
Immunochemical and LC-MS/MS Detection of Protein Adduction Resulting from Metabolic Activation of Columbin In Vitro and In Vivo.
Wu C, Pan J, Gong B, Liao Y, Zou Y, Wang Y, Ran G, Wang X, Zhou M, Liu T, Peng Y, Li W, Zheng J. Wu C, et al. Chem Res Toxicol. 2023 Apr 17;36(4):691-702. doi: 10.1021/acs.chemrestox.3c00006. Epub 2023 Mar 28. Chem Res Toxicol. 2023. PMID: 36976707
Columbin (CLB) is a diterpenoid furanolactone compound occurring in some herbal medicines. ...
Columbin (CLB) is a diterpenoid furanolactone compound occurring in some herbal medicines. ...
Columbin isolated from calumbae radix affects the sleeping time of anesthetized mice.
Wada K, Kurihara T, Yagi M, Kobayashi R, Kaminaga H, Toi K, Haga M. Wada K, et al. Biol Pharm Bull. 1995 Apr;18(4):634-6. doi: 10.1248/bpb.18.634. Biol Pharm Bull. 1995. PMID: 7655444
In a screening series of bioactive components in edible and medicinal plants, we found that Calumbae Radix (Colombo root, 1% powdered feed, for 5 d) and its component, columbin (20-40 mg/kg/d, for 5 d, orally), shortened the sleeping time induced by a urethane and alpha-ch …
In a screening series of bioactive components in edible and medicinal plants, we found that Calumbae Radix (Colombo root, 1% powdered feed, …
Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies.
Yang G, Gao S, Sun R, Yin T, Hu M. Yang G, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:13-8. doi: 10.1016/j.jchromb.2015.07.030. Epub 2015 Aug 7. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 26295697 Free PMC article.
The validated method was used to determine the pharmacokinetic profile of columbin in Wistar rats, and its transport characteristics in the Caco-2 cell culture model. ...The results revealed that the validated method can be used for columbin analysis in both bioequi …
The validated method was used to determine the pharmacokinetic profile of columbin in Wistar rats, and its transport characteristics …
Method development and validation for quantification of six bioactive compounds (andrographolide, columbin, piperine, gallic, paracoumaric and oleanolic acids) by HPTLC.
Shanmugam M, Subramanian S, Ramachandran S. Shanmugam M, et al. J Complement Integr Med. 2022 Nov 16;20(1):137-145. doi: 10.1515/jcim-2022-0135. eCollection 2023 Mar 1. J Complement Integr Med. 2022. PMID: 36384045
METHODS: A precise, reliable and sensitive ordinary phase high performance thin layer chromatography (HPTLC) method has been developed and validated for identification and simultaneous estimation of six bioactive components namely like andrographolide, columbin, gallic aci …
METHODS: A precise, reliable and sensitive ordinary phase high performance thin layer chromatography (HPTLC) method has been developed and v …
27 results