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Results: 1 to 20 of 57


Kinetic Model for NS1643 Drug Activation of WT and L529I Variants of Kv11.1 (hERG1) Potassium Channel.

Perissinotti LL, Guo J, De Biase PM, Clancy CE, Duff HJ, Noskov SY.

Biophys J. 2015 Mar 24;108(6):1414-24. doi: 10.1016/j.bpj.2014.12.056.


Na(+) /Ca(2+) exchange and Na(+) /K(+) -ATPase in the heart.

Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ.

J Physiol. 2015 Mar 15;593(6):1361-82. doi: 10.1113/jphysiol.2014.282319.


Na(+) channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428.


Deranged sodium to sudden death.

Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, VarrĂ³ A, Zaza A.

J Physiol. 2015 Mar 15;593(6):1331-45. doi: 10.1113/jphysiol.2014.281204.


A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na(+) current.

Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy CE.

J Physiol. 2015 Mar 15;593(6):1429-42. doi: 10.1113/jphysiol.2014.279554.


Role of membrane microdomains in compartmentation of cAMP signaling.

Agarwal SR, Yang PC, Rice M, Singer CA, Nikolaev VO, Lohse MJ, Clancy CE, Harvey RD.

PLoS One. 2014 Apr 21;9(4):e95835. doi: 10.1371/journal.pone.0095835. eCollection 2014.


In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome.

Romero L, Trenor B, Yang PC, Saiz J, Clancy CE.

J Mol Cell Cardiol. 2014 Jul;72:126-37. doi: 10.1016/j.yjmcc.2014.02.018. Epub 2014 Mar 11.


Biological techniques: Wrapped around the heart.

Clancy CE, Xiang YK.

Nature. 2014 Mar 6;507(7490):43-4. doi: 10.1038/507043a. No abstract available.


Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.

Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE.

Circ Res. 2013 Sep 13;113(7):e50-61. doi: 10.1161/CIRCRESAHA.113.301971. Epub 2013 Jul 29.


An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia.

Nawathe PA, Kryukova Y, Oren RV, Milanesi R, Clancy CE, Lu JT, Moss AJ, Difrancesco D, Robinson RB.

J Cardiovasc Electrophysiol. 2013 Sep;24(9):1021-7. doi: 10.1111/jce.12163. Epub 2013 Apr 30.


Cardiac electrophysiological dynamics from the cellular level to the organ level.

Sato D, Clancy CE.

Biomed Eng Comput Biol. 2013 Aug 26;5:69-75. doi: 10.4137/BECB.S10960. eCollection 2013. Review.


Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons.

Lewin N, Aksay E, Clancy CE.

PLoS One. 2012;7(10):e47250. doi: 10.1371/journal.pone.0047250. Epub 2012 Oct 12. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/d6af29ee-25c0-4f8e-910e-afe53ef8f963.


In silico Prediction of Sex-Based Differences in Human Susceptibility to Cardiac Ventricular Tachyarrhythmias.

Yang PC, Clancy CE.

Front Physiol. 2012 Sep 14;3:360. doi: 10.3389/fphys.2012.00360. eCollection 2012.


Sex and gender aspects in antiarrhythmic therapy.

Kurokawa J, Kodama M, Furukawa T, Clancy CE.

Handb Exp Pharmacol. 2012;(214):237-63. doi: 10.1007/978-3-642-30726-3_12. Review.


Computational approaches to understand cardiac electrophysiology and arrhythmias.

Roberts BN, Yang PC, Behrens SB, Moreno JD, Clancy CE.

Am J Physiol Heart Circ Physiol. 2012 Oct 1;303(7):H766-83. doi: 10.1152/ajpheart.01081.2011. Epub 2012 Aug 10. Review.


Pathophysiology of the cardiac late Na current and its potential as a drug target.

Moreno JD, Clancy CE.

J Mol Cell Cardiol. 2012 Mar;52(3):608-19. doi: 10.1016/j.yjmcc.2011.12.003. Epub 2011 Dec 16. Review.


A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms.

Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE.

Sci Transl Med. 2011 Aug 31;3(98):98ra83. doi: 10.1126/scitranslmed.3002588.


Gender-based differences in cardiac diseases.

Yang PC, Clancy CE.

J Biomed Res. 2011 Mar;25(2):81-9. doi: 10.1016/S1674-8301(11)60010-9.


Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study.

Oren RV, Clancy CE.

PLoS Comput Biol. 2010 Dec 23;6(12):e1001041. doi: 10.1371/journal.pcbi.1001041.


Arrhythmia models: in vivo, in vitro and in silico.

Akar FG, Clancy CE.

Drug Discov Today Dis Models. 2009 Fall;6(3):55-56. No abstract available.

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