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Results: 1 to 20 of 43


Independent Effects of GABA Transaminase (GABAT) on Metabolic and Sleep Homeostasis.

Maguire SE, Rhoades S, Chen WF, Sengupta A, Yue Z, Lim JC, Mitchell CH, Weljie AM, Sehgal A.

J Biol Chem. 2015 Jun 29. pii: jbc.M114.602276. [Epub ahead of print]


Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification.

Lööv C, Mitchell CH, Simonsson M, Erlandsson A.

Glia. 2015 Jun 12. doi: 10.1002/glia.22873. [Epub ahead of print]


Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye.

Lu W, Hu H, Sévigny J, Gabelt BT, Kaufman PL, Johnson EC, Morrison JC, Zode GS, Sheffield VC, Zhang X, Laties AM, Mitchell CH.

Invest Ophthalmol Vis Sci. 2015 May 1;56(5):3075-83. doi: 10.1167/iovs.14-15891.


Normal Taste Acceptance and Preference of PANX1 Knockout Mice.

Tordoff MG, Aleman TR, Ellis HT, Ohmoto M, Matsumoto I, Shestopalov VI, Mitchell CH, Foskett JK, Poole RL.

Chem Senses. 2015 May 18. pii: bjv025. [Epub ahead of print]


Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder.

Beckel JM, Daugherty SL, Tyagi P, Wolf-Johnston AS, Birder LA, Mitchell CH, de Groat WC.

J Physiol. 2015 Apr 15;593(8):1857-71. doi: 10.1113/jphysiol.2014.283119. Epub 2015 Feb 11.


The Contribution of Melanoregulin to Microtubule-Associated Protein 1 Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment Epithelium.

Frost LS, Lopes VS, Bragin A, Reyes-Reveles J, Brancato J, Cohen A, Mitchell CH, Williams DS, Boesze-Battaglia K.

Mol Neurobiol. 2014 Oct 10. [Epub ahead of print]


Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: evidence for a role in retinal degenerations.

Guha S, Coffey EE, Lu W, Lim JC, Beckel JM, Laties AM, Boesze-Battaglia K, Mitchell CH.

Exp Eye Res. 2014 Sep;126:68-76. doi: 10.1016/j.exer.2014.05.013. Review.


Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.

Sanderson J, Dartt DA, Trinkaus-Randall V, Pintor J, Civan MM, Delamere NA, Fletcher EL, Salt TE, Grosche A, Mitchell CH.

Exp Eye Res. 2014 Oct;127:270-9. doi: 10.1016/j.exer.2014.08.009. Epub 2014 Aug 20. Review.


Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain.

Beckel JM, Argall AJ, Lim JC, Xia J, Lu W, Coffey EE, Macarak EJ, Shahidullah M, Delamere NA, Zode GS, Sheffield VC, Shestopalov VI, Laties AM, Mitchell CH.

Glia. 2014 Sep;62(9):1486-501. doi: 10.1002/glia.22695. Epub 2014 May 19.


Autophagy in the eye: implications for ocular cell health.

Frost LS, Mitchell CH, Boesze-Battaglia K.

Exp Eye Res. 2014 Jul;124:56-66. doi: 10.1016/j.exer.2014.04.010. Epub 2014 May 6. Review.


Rescue of compromised lysosomes enhances degradation of photoreceptor outer segments and reduces lipofuscin-like autofluorescence in retinal pigmented epithelial cells.

Guha S, Liu J, Baltazar G, Laties AM, Mitchell CH.

Adv Exp Med Biol. 2014;801:105-11. doi: 10.1007/978-1-4614-3209-8_14. Review.


From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma.

Križaj D, Ryskamp DA, Tian N, Tezel G, Mitchell CH, Slepak VZ, Shestopalov VI.

Curr Eye Res. 2014 Feb;39(2):105-19. doi: 10.3109/02713683.2013.836541. Epub 2013 Oct 21. Review.


Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor.

Guha S, Baltazar GC, Coffey EE, Tu LA, Lim JC, Beckel JM, Patel S, Eysteinsson T, Lu W, O'Brien-Jenkins A, Laties AM, Mitchell CH.

FASEB J. 2013 Nov;27(11):4500-9. doi: 10.1096/fj.13-236166. Epub 2013 Aug 20.


Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium.

Frost LS, Lopes VS, Stefano FP, Bragin A, Williams DS, Mitchell CH, Boesze-Battaglia K.

Vis Neurosci. 2013 May;30(3):55-64. doi: 10.1017/S0952523813000096. Epub 2013 Apr 23.


Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells.

Baltazar GC, Guha S, Lu W, Lim J, Boesze-Battaglia K, Laties AM, Tyagi P, Kompella UB, Mitchell CH.

PLoS One. 2012;7(12):e49635. doi: 10.1371/journal.pone.0049635. Epub 2012 Dec 18.


Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.

Guha S, Baltazar GC, Tu LA, Liu J, Lim JC, Lu W, Argall A, Boesze-Battaglia K, Laties AM, Mitchell CH.

J Neurochem. 2012 Aug;122(4):823-33. doi: 10.1111/j.1471-4159.2012.07804.x. Epub 2012 Jun 27.


Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells.

Liu J, Lu W, Guha S, Baltazar GC, Coffey EE, Laties AM, Rubenstein RC, Reenstra WW, Mitchell CH.

Am J Physiol Cell Physiol. 2012 Jul 15;303(2):C160-9. doi: 10.1152/ajpcell.00278.2011. Epub 2012 May 9.


Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors.

Xia J, Lim JC, Lu W, Beckel JM, Macarak EJ, Laties AM, Mitchell CH.

J Physiol. 2012 May 1;590(Pt 10):2285-304. doi: 10.1113/jphysiol.2012.227983. Epub 2012 Mar 12.


Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma.

Li A, Zhang X, Zheng D, Ge J, Laties AM, Mitchell CH.

Exp Eye Res. 2011 Oct;93(4):528-33. doi: 10.1016/j.exer.2011.06.020. Epub 2011 Jul 2.


Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow.

Li A, Leung CT, Peterson-Yantorno K, Stamer WD, Mitchell CH, Civan MM.

J Cell Physiol. 2012 Jan;227(1):172-82. doi: 10.1002/jcp.22715.

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