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Year Number of Results
1950 1
1952 4
1953 1
1955 1
1956 1
1959 4
1960 1
1961 2
1964 3
1972 1
1973 15
1974 26
1975 37
1976 41
1977 49
1978 104
1979 215
1980 187
1981 292
1982 417
1983 479
1984 676
1985 908
1986 946
1987 963
1988 1065
1989 1282
1990 1403
1991 1351
1992 1450
1993 1533
1994 1500
1995 1520
1996 1600
1997 1641
1998 1591
1999 1737
2000 1811
2001 1778
2002 1924
2003 1918
2004 2014
2005 2164
2006 2353
2007 2342
2008 2359
2009 2513
2010 2813
2011 3029
2012 3298
2013 3454
2014 3649
2015 3826
2016 3902
2017 4015
2018 3999
2019 4103
2020 4380
2021 4471
2022 4272
2023 3877
2024 1324

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90,367 results

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Page 1
Cisplatin.
Trimmer EE, Essigmann JM. Trimmer EE, et al. Essays Biochem. 1999;34:191-211. doi: 10.1042/bse0340191. Essays Biochem. 1999. PMID: 10730196 Review.
Cisplatin is a widely used anti-cancer drug that is exceptionally effective against testicular cancer. trans-DDP, the geometric isomer of cisplatin, is ineffective as a chemotherapeutic agent. ...The adducts of both cis- and trans-DDP are remove …
Cisplatin is a widely used anti-cancer drug that is exceptionally effective against testicular cancer. trans-DDP, the geometri …
Evaluation of the genotoxicity of cis-bis(3-aminoflavone)dichloroplatinum(II) in comparison with cis-DDP.
Kosmider B, Wyszynska K, Janik-Spiechowicz E, Osiecka R, Zyner E, Ochocki J, Ciesielska E, Wasowicz W. Kosmider B, et al. Mutat Res. 2004 Mar 14;558(1-2):93-110. doi: 10.1016/j.mrgentox.2003.11.006. Mutat Res. 2004. PMID: 15036123
In comparison with cis-DDP this compound showed a weaker genotoxicity. Contrary to cis-DDP it has not shown toxic properties in the tester bacteria. ...These results provide important data on the genotoxicity of cis-[Pt(AF)2Cl2] and indicate its …
In comparison with cis-DDP this compound showed a weaker genotoxicity. Contrary to cis-DDP it has not shown toxi …
Trans-diammineplatinum(II): what makes it different from cis-DDP? Coordination chemistry of a neglected relative of cisplatin and its interaction with nucleic acids.
Lippert B. Lippert B. Met Ions Biol Syst. 1996;33:105-41. Met Ions Biol Syst. 1996. PMID: 8742842 Review.
The mutagenic effects of trans-a2Pt(II), although weaker than for cis-DDP, point toward DNA as being an important target for trans-DDP as well. 2. ...With respect to amine displacement from monoadducts of cis-DDP, it is interesting to speculate …
The mutagenic effects of trans-a2Pt(II), although weaker than for cis-DDP, point toward DNA as being an important target for t …
Evaluation of P53 and BAX gene expression and induction of apoptosis and necrosis by the cis-Pt(II) complex of 3-aminoflavone in comparison with cis-diamminedichloroplatinum(II) (cis-DDP) in human lymphocytes.
Kosmider B, Zawlik I, Liberski PP, Osiecka R, Zyner E, Ochocki J, Bartkowiak J. Kosmider B, et al. Mutat Res. 2006 Apr 30;604(1-2):28-35. doi: 10.1016/j.mrgentox.2005.12.006. Epub 2006 Jan 27. Mutat Res. 2006. PMID: 16443387
Currently cis-diamminedichloroplatinum(II) (cis-DDP) is one of the most commonly applied compounds in chemotherapy of many types of cancer. ...Therefore, human normal lymphocytes were chosen as a model system to study cis-bis(3-aminoflavone)dichloropla …
Currently cis-diamminedichloroplatinum(II) (cis-DDP) is one of the most commonly applied compounds in chemotherapy of m …
Induction of apoptosis and necrosis in A549 cells by the cis-Pt(II) complex of 3-aminoflavone in comparison with cis-DDP.
Kosmider B, Zyner E, Osiecka R, Ochocki J. Kosmider B, et al. Mutat Res. 2004 Sep 12;563(1):61-70. doi: 10.1016/j.mrgentox.2004.05.018. Mutat Res. 2004. PMID: 15324749
Therefore, the cis-Pt(II) complex of 3-aminoflavone was selected from cis-DDP analogues with a more favourable toxic profile towards normal cells and at least similar or better anti-tumor activity in comparison with cis-DDP. The aim of this rese …
Therefore, the cis-Pt(II) complex of 3-aminoflavone was selected from cis-DDP analogues with a more favourable toxic pr …
[Cis-diamminedichloroplatinum(II): a new type of cytostatic].
Sonntag RW. Sonntag RW. Onkologie. 1979 Jun;2(3):129-33. doi: 10.1159/000214497. Onkologie. 1979. PMID: 118414 Review. German.
Cis-diamminedichloroplatinum(II) (DDP) represents a new class of platinum compounds with cytostatic activity. ...The toxicology, metabolism, mode of application and clinical experience with this drug are presented and discussed. The value of DDP as monotherap …
Cis-diamminedichloroplatinum(II) (DDP) represents a new class of platinum compounds with cytostatic activity. ...The toxicolog …
Comparison between the genotoxicity of cis-Pt(ll) complex of 3-aminoflavone and cis-DDP in lymphocytes evaluated by the comet assay.
Kosmider B, Osiecka R, Zyner E, Ochocki J. Kosmider B, et al. Drug Chem Toxicol. 2005;28(2):231-44. doi: 10.1081/dct-52555. Drug Chem Toxicol. 2005. PMID: 15865263
cis-bis(3-aminoflavone)dichloroplatinum(II) [cis-Pt(II) complex of 3-aminoflavone] is an analog of cis-DDP characterized by low cytotoxicity and anticancer properties in vivo. ...It has been shown that cis-Pt(II) complex of 3-aminoflavone causes …
cis-bis(3-aminoflavone)dichloroplatinum(II) [cis-Pt(II) complex of 3-aminoflavone] is an analog of cis-DDP chara …
Ototoxicity of cis-diamminedichloroplatinum.
Vodvárka P, Foukalová J, Mrázek J, Philippová J. Vodvárka P, et al. Neoplasma. 1985;32(2):229-38. Neoplasma. 1985. PMID: 4039797
In 19 evaluable cancer patients treated with cis-diamminedichloroplatinum (cis-DDP) Platidiam-Lachema containing chemotherapy the ototoxicity was assessed. ...To avoid serious cis-DDP ototoxicity it is necessary to monitor renal functions and au …
In 19 evaluable cancer patients treated with cis-diamminedichloroplatinum (cis-DDP) Platidiam-Lachema containing chemot …
Induction of apoptosis and necrosis in lymphocytes by the cis-Pt(II) complex of 3-aminoflavone in comparison with cis-DDP.
Kosmider B, Osiecka R, Ciesielska E, Szmigiero L, Zyner E, Ochocki J. Kosmider B, et al. Mutat Res. 2004 Mar 14;558(1-2):169-79. doi: 10.1016/j.mrgentox.2003.12.004. Mutat Res. 2004. PMID: 15036130
cis-Diamminedichloroplatinum(II) (cis-DDP) is one of the most widely administrated antitumor drugs. ...The cytotoxicity was evaluated by MTT. The results obtained show that the cis-Pt(II) complex of 3-aminoflavone is less toxic than cis-DDP …
cis-Diamminedichloroplatinum(II) (cis-DDP) is one of the most widely administrated antitumor drugs. ...The cytotoxicity …
Melting of complexes of DNA-cis-DDP in acidic environment.
Dalyan YB, Haroutiunian TS, Haroutiunian SG, Vardevanyan PO. Dalyan YB, et al. Exp Mol Med. 2003 Dec 31;35(6):534-7. doi: 10.1038/emm.2003.69. Exp Mol Med. 2003. PMID: 14749531
The peculiarities of helix-coil transition of DNA at complex-formation with cis-diamminedichlorplatinum (II) (cis-DDP) have been investigated in acidic environment by UV absorbance technique. It is shown that observed features of behavior T (pH) and T(m) (pH) …
The peculiarities of helix-coil transition of DNA at complex-formation with cis-diamminedichlorplatinum (II) (cis-DDP) …
90,367 results
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