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Year Number of Results
1979 2
1980 1
1981 2
1982 3
1983 6
1984 3
1985 8
1986 6
1987 4
1988 1
1989 2
2024 0

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38 results

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Page 1
Oral ciramadol in the treatment of postoperative pain.
Lasagna L, Calimlim JF. Lasagna L, et al. Clin Pharmacol Ther. 1985 Aug;38(2):176-82. doi: 10.1038/clpt.1985.155. Clin Pharmacol Ther. 1985. PMID: 3839446 Clinical Trial.
The differences between 15 mg ciramadol and 650 mg aspirin were generally not significant, although the higher aspirin dose had some advantages over 15 mg ciramadol. The most frequently reported adverse effect was dizziness/vertigo in 22% of patients taking 60 mg …
The differences between 15 mg ciramadol and 650 mg aspirin were generally not significant, although the higher aspirin dose had some …
Oral ciramadol: a new analgesic for postoperative pain.
Reines HD, Hunt P, Rambo W, Loadholt CB. Reines HD, et al. J Clin Pharmacol. 1986 Feb;26(2):111-4. doi: 10.1002/j.1552-4604.1986.tb02917.x. J Clin Pharmacol. 1986. PMID: 3753988 Clinical Trial.
Doses of ciramadol 30 mg were significantly (P less than .05) more effective than aspirin 650 mg at several time periods, and ciramadol 60 mg was better than pentazocine and placebo at several evaluation times. The 30-mg dose of ciramadol was generally more e …
Doses of ciramadol 30 mg were significantly (P less than .05) more effective than aspirin 650 mg at several time periods, and cira …
Intramuscularly administered ciramadol for management of postoperative pain: a comparative study.
Fragen RJ, Kouzmanoff C, Caldwell NJ. Fragen RJ, et al. J Clin Pharmacol. 1983 May-Jun;23(5-6):219-26. doi: 10.1002/j.1552-4604.1983.tb02728.x. J Clin Pharmacol. 1983. PMID: 6348105 Clinical Trial.
Efficacy and safety of the analgesic ciramadol in the management of postoperative pain was evaluated in 139 healthy patients given single, double-blind, intramuscular injections of either 30 mg ciramadol, 60 mg ciramadol, 10 mg morphine or 0.9% saline on the …
Efficacy and safety of the analgesic ciramadol in the management of postoperative pain was evaluated in 139 healthy patients given si …
Inhibition of ciramadol glucuronidation by benzodiazepines.
Meacham RH Jr, Sisenwine SF, Liu AL, Kick CJ, Barinov I, Ruelius HW. Meacham RH Jr, et al. Drug Metab Dispos. 1986 Jul-Aug;14(4):430-6. Drug Metab Dispos. 1986. PMID: 2873990
Each benzodiazepine appeared to be a competitive inhibitor of ciramadol and morphine UDP-glucuronyltransferase activity. The in vivo disposition of ciramadol was unchanged in dogs pretreated with lorazepam. ...Since glucuronidation plays a major role in the eliminat …
Each benzodiazepine appeared to be a competitive inhibitor of ciramadol and morphine UDP-glucuronyltransferase activity. The in vivo …
Comparative evaluation of ciramadol (WY-15.705), morphine and placebo for treatment of postoperative pain.
Van den Abeele G, Camu F. Van den Abeele G, et al. Acta Anaesthesiol Belg. 1985 Jun;36(2):97-110. Acta Anaesthesiol Belg. 1985. PMID: 3898701 Clinical Trial.
All active therapy groups provided better analgesia than the placebo group. The estimated relative analgesic potency of ciramadol to morphine was 0.3 to 1. Some increase in sedation level was seen following therapy in each group with the largest increase in the ciramado …
All active therapy groups provided better analgesia than the placebo group. The estimated relative analgesic potency of ciramadol to …
Low ceiling respiratory depression by ciramadol.
Romagnoli A, Keats AS. Romagnoli A, et al. Int J Clin Pharmacol Res. 1986;6(6):451-5. Int J Clin Pharmacol Res. 1986. PMID: 3100462
In contrast to the progressive respiratory depression by each 10 mg/70 kg increment of morphine, further doses of ciramadol up to 90 mg/70 kg failed to increase respiratory depression. The ceiling of respiratory depression by ciramadol was half the ceiling previousl …
In contrast to the progressive respiratory depression by each 10 mg/70 kg increment of morphine, further doses of ciramadol up to 90 …
Ciramadol. A new analgesic.
Cochrane AD, Bell R, Sullivan JR, Shaw J. Cochrane AD, et al. Med J Aust. 1979 Nov 3;2(9):501-2. Med J Aust. 1979. PMID: 522808
Ciramadol (WY 15705), a new analgesic and narcotic antagonist was studied on oral-dose form in 16 patients (15 of whom were suffering from malignant disease) to evaluate the analgesic dose and toxicity. ...
Ciramadol (WY 15705), a new analgesic and narcotic antagonist was studied on oral-dose form in 16 patients (15 of whom were suffering …
Ciramadol. The therapeutic dose range during balanced anesthesia.
Camu F, Heytens L, Claeys MA. Camu F, et al. Acta Anaesthesiol Belg. 1985 Mar;36(1):23-31. Acta Anaesthesiol Belg. 1985. PMID: 3839340
The mean requirements of ciramadol during surgery were inferred from each patient's time-dose curve. The mean loading dose of ciramadol needed was 2.5 +/- 0.4 mg/kg and for maintenance of the analgesic effects, ciramadol had to be administered at a rate of 0. …
The mean requirements of ciramadol during surgery were inferred from each patient's time-dose curve. The mean loading dose of cira …
Ciramadol as analgesic adjunct to anesthesia in short surgical procedures.
Camu F, Heytens L, Claeys MA. Camu F, et al. Acta Anaesthesiol Belg. 1985 Dec;36(4):381-9. Acta Anaesthesiol Belg. 1985. PMID: 3938175
Sixty female patients received either ciramadol 2 mg.kg-1 or saline before anesthesia induction with thiopental-succinylcholine followed by enflurane maintenance. ...Addition of enflurane also had no deleterious effects on the cardiovascular performance in the ciramadol …
Sixty female patients received either ciramadol 2 mg.kg-1 or saline before anesthesia induction with thiopental-succinylcholine follo …
DMI, Wy-45,030, Wy-45,881 and ciramadol inhibit locus coeruleus neuronal activity.
Haskins JT, Moyer JA, Muth EA, Sigg EB. Haskins JT, et al. Eur J Pharmacol. 1985 Sep 24;115(2-3):139-46. doi: 10.1016/0014-2999(85)90684-3. Eur J Pharmacol. 1985. PMID: 2998818
To further characterize their activity, these compounds were compared to desipramine and ciramadol in electrophysiological studies of their acute effects on noradrenergic neuronal activity. ...Pretreatment with naloxone prevented the reduction in locus coeruleus impulse fl …
To further characterize their activity, these compounds were compared to desipramine and ciramadol in electrophysiological studies of …
38 results