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Network pharmacological mechanism of Cinobufotalin against glioma.
Li C, Guo H, Wang C, Zhan W, Tan Q, Xie C, Sharma A, Sharma HS, Chen L, Zhang Z. Li C, et al. Prog Brain Res. 2021;265:119-137. doi: 10.1016/bs.pbr.2021.06.001. Epub 2021 Aug 13. Prog Brain Res. 2021. PMID: 34560920
OBJECTIVE: Cinobufotalin was extracted from the skin of Chinese giant salamander or black sable with good clinical effect against tumor. This study aims to explore the mechanism of Cinobufotalin components and predict the target of action of Cinobufotalin on …
OBJECTIVE: Cinobufotalin was extracted from the skin of Chinese giant salamander or black sable with good clinical effect against tum …
Safety reassessment of cinobufotalin injection: new findings into cardiotoxicity.
Li M, Wang X, Qiu Y, Zhang Y, Pan X, Tang N, Chen T, Ruan B, Shao S, He L, Li H, Ma J. Li M, et al. Toxicol Res (Camb). 2020 Jun 12;9(4):390-398. doi: 10.1093/toxres/tfaa035. eCollection 2020 Jul. Toxicol Res (Camb). 2020. PMID: 32905219 Free PMC article.
Cinobufotalin injection, a traditional Chinese medicine preparation, successfully used for several years, might induce cardiotoxicity. ...The cardiotoxicity of cinobufotalin injection was attenuated by sodium phenytoin in treatment phase V. ...
Cinobufotalin injection, a traditional Chinese medicine preparation, successfully used for several years, might induce cardiotoxicity …
Cinobufotalin Induces Ferroptosis to Suppress Lung Cancer Cell Growth by lncRNA LINC00597/hsa-miR-367-3p/TFRC Pathway via Resibufogenin.
Huang J, Deng C, Guo T, Chen X, Chen P, Du S, Lu M. Huang J, et al. Anticancer Agents Med Chem. 2023;23(6):717-725. doi: 10.2174/1871520622666221010092922. Anticancer Agents Med Chem. 2023. PMID: 36221890
Besides, cinobufotalin induced ferroptosis in lung cancer cells through resibufogenin. Moreover, cinobufotalin increased lncRNA LINC00597 level, whereas it downregulated hsa-miR-367-3p expression in lung cancer cells via resibufogenin. ...
Besides, cinobufotalin induced ferroptosis in lung cancer cells through resibufogenin. Moreover, cinobufotalin increased lncRN …
The Potential Mechanisms of Cinobufotalin Treating Colon Adenocarcinoma by Network Pharmacology.
Wang J, Chang H, Su M, Zhao H, Qiao Y, Wang Y, Shang L, Shan C, Zhang S. Wang J, et al. Front Pharmacol. 2022 Jun 23;13:934729. doi: 10.3389/fphar.2022.934729. eCollection 2022. Front Pharmacol. 2022. PMID: 35814224 Free PMC article.
Targets overlapped between COAD-associated proteins and cinobufotalin target proteins were used to filter candidate targets of cinobufotalin in COAD. ...Molecular docking results showed that cinobufotalin matches in the pocket of the top candidate cinobufo …
Targets overlapped between COAD-associated proteins and cinobufotalin target proteins were used to filter candidate targets of cin …
Cinobufotalin inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells through down-regulate beta-catenin in vitro and in vivo.
Li W, Pei S, Zhang X, Qi D, Zhang W, Dou Y, Yang R, Yao X, Zhang Z, Xie S, Fang D, Sun H. Li W, et al. Eur J Pharmacol. 2022 May 5;922:174886. doi: 10.1016/j.ejphar.2022.174886. Epub 2022 Mar 12. Eur J Pharmacol. 2022. PMID: 35292248
MMP7 and DKK1), which are related to tumor invasion and metastasis, were decreased after cinobufotalin treatment. Overexpression of beta-catenin promoted EMT of HepG2 and SMMC-7721 cells, and cinobufotalin could antagonize this induction. ...These results provide co …
MMP7 and DKK1), which are related to tumor invasion and metastasis, were decreased after cinobufotalin treatment. Overexpression of b …
Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer.
Han Y, Ma R, Cao G, Liu H, He L, Tang L, Li H, Luo Q. Han Y, et al. Evid Based Complement Alternat Med. 2021 Mar 20;2021:6612365. doi: 10.1155/2021/6612365. eCollection 2021. Evid Based Complement Alternat Med. 2021. PMID: 34122599 Free PMC article.
A549 cells were treated with gefitinib, cinobufotalin, or cinobufotalin plus gefitinib. MTT assay, annexin-V/PI staining and flow cytometry, TUNEL staining, DCFH-DA staining, Western blot, and real-time RT-PCR were performed to investigate the synergistic inhibitory …
A549 cells were treated with gefitinib, cinobufotalin, or cinobufotalin plus gefitinib. MTT assay, annexin-V/PI staining and f …
Cinobufotalin effect and mechanism on serum MMP-2, MMP-9, Beclin1, LC3-II in advanced NSCLC patients.
Yang L, Bai B, Chen H, Li T, Wang M, Zhu X. Yang L, et al. Cell Mol Biol (Noisy-le-grand). 2023 Dec 31;69(15):58-62. doi: 10.14715/cmb/2023.69.15.9. Cell Mol Biol (Noisy-le-grand). 2023. PMID: 38279494
This study was conducted to explore cinobufotalin's effects and related mechanisms on serum MMP-2, MMP-9, Beclin1, and LC3-II in advanced non-small-cell lung cancer (NSCLC) patients. ...Group C received conventional NP regimen chemotherapy, while Group O received cinobu …
This study was conducted to explore cinobufotalin's effects and related mechanisms on serum MMP-2, MMP-9, Beclin1, and LC3-II in adva …
[Inhibitory Effect of Cinobufotalin on Macrophage Inflammatory Factor Storm and Its Mechanism].
Liu XX, Li CC, Yang J, Zhang WG, Jianati RA, Zhang XL, Xu ZQ, Dai XB, Tian F, Chen BQ, Zhu XJ. Liu XX, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2023 Jun;31(3):880-888. doi: 10.19746/j.cnki.issn.1009-2137.2023.03.039. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2023. PMID: 37356955 Chinese.
OBJECTIVE: To investigate the inflammatory effects of Cinobufotalin on monocytes in resting state and macrophages in activated state and its molecular mechanism. ...Lipopolysaccharides was added to activate macrophages in order to establish macrophage activation model. …
OBJECTIVE: To investigate the inflammatory effects of Cinobufotalin on monocytes in resting state and macrophages in activated state …
Network Pharmacology Prediction: The Possible Mechanisms of Cinobufotalin against Osteosarcoma.
Chen R, Guan Z, Zhong X, Zhang W, Zhang Y. Chen R, et al. Comput Math Methods Med. 2022 Jan 13;2022:3197402. doi: 10.1155/2022/3197402. eCollection 2022. Comput Math Methods Med. 2022. PMID: 35069780 Free PMC article. Retracted.
OBJECTIVE: To explore the active compounds and targets of cinobufotalin (huachansu) compared with the osteosarcoma genes to obtain the potential therapeutic targets and pharmacological mechanisms of action of cinobufotalin on osteosarcoma through network pharmacolog …
OBJECTIVE: To explore the active compounds and targets of cinobufotalin (huachansu) compared with the osteosarcoma genes to obtain th …
Cinobufotalin as an effective adjuvant therapy for advanced gastric cancer: a meta-analysis of randomized controlled trials.
Sun H, Wang W, Bai M, Liu D. Sun H, et al. Onco Targets Ther. 2019 Apr 26;12:3139-3160. doi: 10.2147/OTT.S196684. eCollection 2019. Onco Targets Ther. 2019. PMID: 31118669 Free PMC article.
The results indicated that, compared with chemotherapy alone, the combination of chemotherapy and cinobufotalin significantly improved patients' overall response rate (odds ratio [OR] =1.88, 95% confidence interval [CI] =1.54-2.31, P<0.00001) and disease control rate (O …
The results indicated that, compared with chemotherapy alone, the combination of chemotherapy and cinobufotalin significantly improve …
82 results

Searches related to "cinobufotalin"