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Page 1
Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe.
Klunk WE, Debnath ML, Pettegrew JW. Klunk WE, et al. Neurobiol Aging. 1995 Jul-Aug;16(4):541-8. doi: 10.1016/0197-4580(95)00058-m. Neurobiol Aging. 1995. PMID: 8544903
Chrysamine-G (CG) is a carboxylic acid analogue of Congo red, a histologic dye which stains amyloid. ...
Chrysamine-G (CG) is a carboxylic acid analogue of Congo red, a histologic dye which stains amyloid. ...
Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells.
Klunk WE, Debnath ML, Koros AM, Pettegrew JW. Klunk WE, et al. Life Sci. 1998;63(20):1807-14. doi: 10.1016/s0024-3205(98)00454-8. Life Sci. 1998. PMID: 9820124
Chrysamine-G showed a concentration-dependent inhibition of A beta[25-35]-induced toxicity. This protective effect became significant at 0.2 microM, a concentration very close to the Ki for Chrysamine-G binding to synthetic A beta (0.37 microM). A deca …
Chrysamine-G showed a concentration-dependent inhibition of A beta[25-35]-induced toxicity. This protective effect became sign …
Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice.
Ishii K, Klunk WE, Arawaka S, Debnath ML, Furiya Y, Sahara N, Shoji S, Tamaoka A, Pettegrew JW, Mori H. Ishii K, et al. Neurosci Lett. 2002 Nov 15;333(1):5-8. doi: 10.1016/s0304-3940(02)00915-1. Neurosci Lett. 2002. PMID: 12401547
The neurotoxicity of amyloid beta (Abeta) is widely believed to play a seminal role in neurodegeneration in Alzheimer's disease. We examined the effect of Chrysamine G (CG) on such neurotoxicity using the specific measurement of surviving neurons. ...
The neurotoxicity of amyloid beta (Abeta) is widely believed to play a seminal role in neurodegeneration in Alzheimer's disease. We examined …
99mTc-MAMA-chrysamine G, a probe for beta-amyloid protein of Alzheimer's disease.
Dezutter NA, Dom RJ, de Groot TJ, Bormans GM, Verbruggen AM. Dezutter NA, et al. Eur J Nucl Med. 1999 Nov;26(11):1392-9. doi: 10.1007/s002590050470. Eur J Nucl Med. 1999. PMID: 10552079
Chrysamine G (CG), an analogue of Congo red, is known to bind in vitro to the beta-amyloid protein (Abeta 10-43) and to homogenates of several regions of the brain of Alzheimer's disease (AD) patients. ...
Chrysamine G (CG), an analogue of Congo red, is known to bind in vitro to the beta-amyloid protein (Abeta 10-43) and to homoge …
Radioiodinated (Z)-2-(4-(2-hydroxyethoxy)benzylidene)-5-iodobenzofuran-3(2H)-one.
Shan L. Shan L. 2011 Nov 30 [updated 2011 Dec 28]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2011 Nov 30 [updated 2011 Dec 28]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 22220319 Free Books & Documents. Review.
Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an effort was made to develop imaging agents with these dyes. ...
Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an e …
Evaluation of 99mTc-MAMA-chrysamine G as an in vivo probe for amyloidosis.
Dezutter NA, Landman WJ, Jager PL, de Groot TJ, Dupont PJ, Tooten PC, Zekarias B, Gruys E, Verbruggen AM. Dezutter NA, et al. Amyloid. 2001 Sep;8(3):202-14. doi: 10.3109/13506120109007363. Amyloid. 2001. PMID: 11676297
We developed 99mTc-MAMA-CG, a 99mTc-labelled derivative of the lipophilic Congo red analogue chrysamine G (CG), as a possible alternative to 123I-SAP. In vivo 99mTc-MAMA-CG scintigraphy, performed in chickens with spontaneous joint amyloidosis, resulted as soon as 1 …
We developed 99mTc-MAMA-CG, a 99mTc-labelled derivative of the lipophilic Congo red analogue chrysamine G (CG), as a possible …
99mTc-Bis-amino-bis-thiol-conjugated 6-(3-bromopropoxy)-2-(4-(dimethylamino)phenyl)-4H-chromen-4-one and (Z)-5-(3-bromopropoxy)-2-(4-(dimethylamino)benzylidene)benzofuran-3(2H)-one.
Shan L. Shan L. 2011 Nov 30 [updated 2011 Dec 28]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2011 Nov 30 [updated 2011 Dec 28]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 22220317 Free Books & Documents. Review.
Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an effort was made to develop imaging agents with these dyes. ...
Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an e …
Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain.
Mathis CA, Wang Y, Klunk WE. Mathis CA, et al. Curr Pharm Des. 2004;10(13):1469-92. doi: 10.2174/1381612043384772. Curr Pharm Des. 2004. PMID: 15134570 Review.
The structures of these agents vary from large proteins and peptides such as radiolabeled A beta peptides and monoclonal antibodies to small molecules derived from Congo red, Chrysamine-G, thioflavin-T, and Acridine Orange. In vitro studies indicate that amyloid pla …
The structures of these agents vary from large proteins and peptides such as radiolabeled A beta peptides and monoclonal antibodies to small …
Fluorinated and iodinated (Z)-2-(4-(2-fluoroethoxy)benzylidene)-5-iodobenzofuran-3(2H)-one.
Shan L. Shan L. 2011 Nov 30 [updated 2011 Dec 28]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2011 Nov 30 [updated 2011 Dec 28]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 22220320 Free Books & Documents. Review.
Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an effort was made to develop imaging agents with these dyes. ...
Based on the fact that Abeta can be specifically stained in vitro with dyes of Congo red, chrysamine G, and thioflavin-T, an e …
In vitro affinity of 99Tcm-labelled N2S2 conjugates of chrysamine G for amyloid deposits of systemic amyloidosis.
Dezutter NA, Sciot RM, de Groot TJ, Bormans GM, Verbruggen AM. Dezutter NA, et al. Nucl Med Commun. 2001 May;22(5):553-8. doi: 10.1097/00006231-200105000-00014. Nucl Med Commun. 2001. PMID: 11388578
To date, systemic amyloidosis is diagnosed histologically in vitro using Congo red staining or in vivo using iodine-123 serum amyloid P component (123I-SAP) scintigraphy. 99Tcm-labelled derivatives of chrysamine G (CG), a lipophilic analogue of Congo red, were synth …
To date, systemic amyloidosis is diagnosed histologically in vitro using Congo red staining or in vivo using iodine-123 serum amyloid P comp …
26 results