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Results: 1 to 20 of 234

1.

New Mechanisms of Flucytosine Resistance in C. glabrata Unveiled by a Chemogenomics Analysis in S. cerevisiae.

Costa C, Ponte A, Pais P, Santos R, Cavalheiro M, Yaguchi T, Chibana H, Teixeira MC.

PLoS One. 2015 Aug 12;10(8):e0135110. doi: 10.1371/journal.pone.0135110. eCollection 2015.

2.

Curation of chemogenomics data.

Fourches D, Muratov E, Tropsha A.

Nat Chem Biol. 2015 Jul 21;11(8):535. doi: 10.1038/nchembio.1881. No abstract available.

PMID:
26196763
3.

A Molecular Pharmacologist's Guide to G Protein-Coupled Receptor Crystallography.

Piscitelli CL, Kean J, de Graaf C, Deupi X.

Mol Pharmacol. 2015 Sep;88(3):536-51. doi: 10.1124/mol.115.099663. Epub 2015 Jul 7.

PMID:
26152196
4.

Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis.

Mattiazzi Ušaj M, Prelec M, Brložnik M, Primo C, Curk T, Ščančar J, Yenush L, Petrovič U.

Metallomics. 2015 Jun 12. [Epub ahead of print]

PMID:
26067383
5.

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.

Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ Jr, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R.

Sci Transl Med. 2015 May 20;7(288):288ra77. doi: 10.1126/scitranslmed.aaa3575.

PMID:
25995223
6.

Druggable cancer secretome: neoplasm-associated traits.

Narayanan R.

Cancer Genomics Proteomics. 2015 May-Jun;12(3):119-31.

PMID:
25977171
7.

KnowLife: a versatile approach for constructing a large knowledge graph for biomedical sciences.

Ernst P, Siu A, Weikum G.

BMC Bioinformatics. 2015 May 14;16:157. doi: 10.1186/s12859-015-0549-5.

8.

Proteochemometric modelling coupled to in silico target prediction: an integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

Paricharak S, Cortés-Ciriano I, IJzerman AP, Malliavin TE, Bender A.

J Cheminform. 2015 Apr 15;7:15. doi: 10.1186/s13321-015-0063-9. eCollection 2015.

9.

Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors.

Yasuda Y, Arakawa T, Nawata Y, Shimada S, Oishi S, Fujii N, Nishimura S, Hattori A, Kakeya H.

Bioorg Med Chem. 2015 Apr 15;23(8):1776-87. doi: 10.1016/j.bmc.2015.02.038. Epub 2015 Feb 25.

PMID:
25773014
10.

Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.

Tokarski JS, Zupa-Fernandez A, Tredup JA, Pike K, Chang C, Xie D, Cheng L, Pedicord D, Muckelbauer J, Johnson SR, Wu S, Edavettal SC, Hong Y, Witmer MR, Elkin LL, Blat Y, Pitts WJ, Weinstein DS, Burke JR.

J Biol Chem. 2015 Apr 24;290(17):11061-74. doi: 10.1074/jbc.M114.619502. Epub 2015 Mar 11.

PMID:
25762719
11.

Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling.

Cortes-Ciriano I, Murrell DS, van Westen GJ, Bender A, Malliavin TE.

J Cheminform. 2015 Jan 16;7:1. doi: 10.1186/s13321-014-0049-z. eCollection 2015.

12.

Maximizing computational tools for successful drug discovery.

Nantasenamat C, Prachayasittikul V.

Expert Opin Drug Discov. 2015 Apr;10(4):321-9. doi: 10.1517/17460441.2015.1016497. Epub 2015 Feb 18.

PMID:
25693813
13.

Correction: In Silico Repositioning-Chemogenomics Strategy Identifies New Drugs with Potential Activity against Multiple Life Stages of Schistosoma mansoni.

PLOS Neglected Tropical Diseases Staff.

PLoS Negl Trop Dis. 2015 Feb 18;9(2):e0003554. doi: 10.1371/journal.pntd.0003554. eCollection 2015 Feb. No abstract available.

14.

A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression.

Kawabata H, Uchiyama T, Sakamoto S, Kanda J, Oishi S, Fujii N, Tomosugi N, Kadowaki N, Takaori-Kondo A.

Exp Hematol. 2015 May;43(5):404-413.e5. doi: 10.1016/j.exphem.2015.01.005. Epub 2015 Jan 26.

PMID:
25633564
15.

In silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of Schistosoma mansoni.

Neves BJ, Braga RC, Bezerra JC, Cravo PV, Andrade CH.

PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3435. doi: 10.1371/journal.pntd.0003435. eCollection 2015 Jan. Erratum in: PLoS Negl Trop Dis. 2015 Feb;9(2):e0003554.

16.

Isolation, structure elucidation, and total synthesis of tryptopeptins A and B, new TGF-β signaling modulators from Streptomyces sp.

Tsunematsu Y, Nishimura S, Hattori A, Oishi S, Fujii N, Kakeya H.

Org Lett. 2015 Jan 16;17(2):258-61. doi: 10.1021/ol503340k. Epub 2015 Jan 5.

PMID:
25560738
17.

Ligand biological activity predictions using fingerprint-based artificial neural networks (FANN-QSAR).

Myint KZ, Xie XQ.

Methods Mol Biol. 2015;1260:149-64. doi: 10.1007/978-1-4939-2239-0_9.

PMID:
25502380
18.

The interplay between molecular modeling and chemoinformatics to characterize protein-ligand and protein-protein interactions landscapes for drug discovery.

Medina-Franco JL, Méndez-Lucio O, Martinez-Mayorga K.

Adv Protein Chem Struct Biol. 2014;96:1-37. doi: 10.1016/bs.apcsb.2014.06.001. Epub 2014 Aug 24.

PMID:
25443953
19.

The 'SAR Matrix' method and its extensions for applications in medicinal chemistry and chemogenomics.

Gupta-Ostermann D, Bajorath J.

Version 2. F1000Res. 2014 May 16 [revised 2014 Jun 23];3:113. doi: 10.12688/f1000research.4185.2. eCollection 2014.

20.

Ligand efficiency-based support vector regression models for predicting bioactivities of ligands to drug target proteins.

Sugaya N.

J Chem Inf Model. 2014 Oct 27;54(10):2751-63. doi: 10.1021/ci5003262. Epub 2014 Sep 22.

PMID:
25220713
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