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Items: 11

1.

Bioactive metabolites from Chaetomium aureum: structure elucidation and inhibition of the Hsp90 machine chaperoning activity.

Kabbaj FZ, Lu S, Faouzi Mel A, Meddah B, Proksch P, Cherrah Y, Altenbach HJ, Aly AH, Chadli A, Debbab A.

Bioorg Med Chem. 2015 Jan 1;23(1):126-31. doi: 10.1016/j.bmc.2014.11.021. Epub 2014 Nov 20.

2.

UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation.

Jilani Y, Lu S, Lei H, Karnitz LM, Chadli A.

Cancer Lett. 2015 Feb 1;357(1):114-20. doi: 10.1016/j.canlet.2014.11.009. Epub 2014 Nov 10.

3.

Progesterone receptor chaperone complex-based high-throughput screening assay: identification of capsaicin as an inhibitor of the Hsp90 machine.

Patwardhan CA, Alfa E, Lu S, Chadli A.

J Biomol Screen. 2015 Feb;20(2):223-9. doi: 10.1177/1087057114549147. Epub 2014 Sep 2.

4.

Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms.

Pye C, Elsherbiny NM, Ibrahim AS, Liou GI, Chadli A, Al-Shabrawey M, Elmarakby AA.

Pharmacol Res. 2014 Jul;85:45-54. doi: 10.1016/j.phrs.2014.05.004. Epub 2014 May 17.

5.

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors.

Paul A, Garcia YA, Zierer B, Patwardhan C, Gutierrez O, Hildenbrand Z, Harris DC, Balsiger HA, Sivils JC, Johnson JL, Buchner J, Chadli A, Cox MB.

J Biol Chem. 2014 May 30;289(22):15297-308. doi: 10.1074/jbc.M113.535229. Epub 2014 Apr 21.

6.

Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis.

Patwardhan CA, Fauq A, Peterson LB, Miller C, Blagg BS, Chadli A.

J Biol Chem. 2013 Mar 8;288(10):7313-25. doi: 10.1074/jbc.M112.427328. Epub 2013 Jan 25.

7.

Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production.

Chen F, Yu Y, Qian J, Wang Y, Cheng B, Dimitropoulou C, Patel V, Chadli A, Rudic RD, Stepp DW, Catravas JD, Fulton DJ.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2989-99. doi: 10.1161/ATVBAHA.112.300361. Epub 2012 Sep 27.

8.

Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production.

Chen F, Pandey D, Chadli A, Catravas JD, Chen T, Fulton DJ.

Antioxid Redox Signal. 2011 Jun;14(11):2107-19. doi: 10.1089/ars.2010.3669. Epub 2011 Mar 13.

9.

Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23.

Chadli A, Felts SJ, Wang Q, Sullivan WP, Botuyan MV, Fauq A, Ramirez-Alvarado M, Mer G.

J Biol Chem. 2010 Feb 5;285(6):4224-31. doi: 10.1074/jbc.M109.081018. Epub 2009 Dec 8.

10.

GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity.

Chadli A, Felts SJ, Toft DO.

J Biol Chem. 2008 Apr 11;283(15):9509-12. doi: 10.1074/jbc.C800017200. Epub 2008 Feb 19.

11.

GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.

Chadli A, Graham JD, Abel MG, Jackson TA, Gordon DF, Wood WM, Felts SJ, Horwitz KB, Toft D.

Mol Cell Biol. 2006 Mar;26(5):1722-30.

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