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Am J Psychiatry. 2002 Dec;159(12):2096-8.

Caudate nucleus volumes and genetic determinants of homocysteine metabolism in the prediction of psychomotor speed in older persons with depression.

Author information

  • 1School of Psychiatry, University of New South Wales, PO Box 1, Rozelle NSW 2039, Sydney, Australia. Sharon_Naismith@wsahs.nsw.gov.au

Abstract

OBJECTIVE:

The authors sought to determine whether caudate nucleus volumes or specific genotypes predict psychomotor slowing in older persons with depression.

METHOD:

Forty-seven persons with depression (mean age=51.8 years, SD=12.4) and 20 healthy volunteers (mean age=56.1 years, SD=9.8) underwent clinical assessments, a neuropsychological test of psychomotor speed (part A of the Trail Making Test), high-resolution magnetic resonance imaging scans, and genotyping for the apolipoprotein E epsilon4 allele and a mutation of the methylenetetrahydrofolate reductase enzyme.

RESULTS:

Multivariate analyses revealed that psychomotor speed was uniquely predicted by age, a diagnosis of depression, right caudate nucleus volume, and mutation of the methylenetetrahydrofolate reductase enzyme.

CONCLUSIONS:

Psychomotor slowing, a key clinical and cognitive phenomenon in older persons with depression, is predicted by reduced caudate nucleus volumes and genetic determinants of homocysteine metabolism.

PMID:
12450963
[PubMed - indexed for MEDLINE]
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