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Hypoxic activation of adventitial fibroblasts: role in vascular remodeling.
Stenmark KR, Gerasimovskaya E, Nemenoff RA, Das M. Stenmark KR, et al. Chest. 2002 Dec;122(6 Suppl):326S-334S. doi: 10.1378/chest.122.6_suppl.326s. Chest. 2002. PMID: 12475810 Review.
Proliferative responses to hypoxia depend on the activation of Galpha(i) and Gq kinase family members, and on the subsequent stimulation of protein kinase C and mitogen-activated protein kinase family members. ...The proliferative effects of ATP appear to be …
Proliferative responses to hypoxia depend on the activation of Galpha(i) and Gq kinase family members, and on the subsequent stimulation of …
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.
Coffer PJ, Woodgett JR. Coffer PJ, et al. Eur J Biochem. 1991 Oct 15;201(2):475-81. doi: 10.1111/j.1432-1033.1991.tb16305.x. Eur J Biochem. 1991. PMID: 1718748 Free article.
The predicted protein was most similar to the protein kinase C (PKC)/cAMP-dependent protein kinase (PKA) families and its gene has thus been termed pkb. Expression of the pkb gene is general but highest in brain, heart and lung. Translation of pkb RNA …
The predicted protein was most similar to the protein kinase C (PKC)/cAMP-dependent protein kinase (PKA) families and i …
Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression.
Short MD, Fox SM, Lam CF, Stenmark KR, Das M. Short MD, et al. Mol Biol Cell. 2006 Apr;17(4):1995-2008. doi: 10.1091/mbc.e05-09-0869. Epub 2006 Feb 8. Mol Biol Cell. 2006. PMID: 16467381 Free PMC article.
Replication repressor activity is unique to PKCzeta because the blockade of classical and novel PKC isozymes does not affect fibroblast proliferation. PKCzeta is phosphorylated upon prolonged (24 h) exposure to hypoxia, whereas ERK1/2, the downstream kinases, are maximally …
Replication repressor activity is unique to PKCzeta because the blockade of classical and novel PKC isozymes does not affect fibroblast …
Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia.
Das M, Burns N, Wilson SJ, Zawada WM, Stenmark KR. Das M, et al. Cardiovasc Res. 2008 Jun 1;78(3):440-8. doi: 10.1093/cvr/cvn014. Epub 2008 Jan 24. Cardiovasc Res. 2008. PMID: 18218684
AIMS: Cultured fibroblasts of hypoxia-stimulated remodelled pulmonary artery (PA) adventitia proliferate at a greater rate compared with those of normal adventitia. Since protein kinase C (PKC) zeta is a replication repressor of normal adventitial f …
AIMS: Cultured fibroblasts of hypoxia-stimulated remodelled pulmonary artery (PA) adventitia proliferate at a greater rate compared w …
Molecular Characterization and Expression Pattern of Gene IGFBP-5 in the Cashmere Goat (Capra hircus).
Wang XJ, Shi JJ, Yang JF, Liang Y, Wang YF, Wu ML, Li SY, Guo XD, Wang ZG, Liu DJ. Wang XJ, et al. Asian-Australas J Anim Sci. 2012 May;25(5):606-12. doi: 10.5713/ajas.2011.11290. Epub 2012 May 1. Asian-Australas J Anim Sci. 2012. PMID: 25049603 Free PMC article.
The full cDNA nucleotide sequence has a 99% identity with sheep, 98% with cattle and 95% with human. The amino acids sequence shares identity with 99%, 99% and 99%, respectively. The bioinformatics analysis showed that IGFBP-5 has an insulin growth factor-binding protein h …
The full cDNA nucleotide sequence has a 99% identity with sheep, 98% with cattle and 95% with human. The amino acids sequence shares …
Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts.
Pemberton AD, Zamolodchikova TS, Scudamore CL, Chilvers ER, Miller HR, Walker TR. Pemberton AD, et al. Eur J Biochem. 2002 Feb;269(4):1171-80. doi: 10.1046/j.1432-1033.2002.02747.x. Eur J Biochem. 2002. PMID: 11856353 Free article.
PAR1, PAR2 and PAR4 activating peptides were unable to induce [3H]thymidine incorporation in pulmonary artery fibroblasts. Likewise, pretreatment of fibroblasts with TNFalpha, known to up-regulate PAR2 expression in other systems, and IL-1beta, did not enhance the p …
PAR1, PAR2 and PAR4 activating peptides were unable to induce [3H]thymidine incorporation in pulmonary artery fibroblasts. Likewise, …