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Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment.
Gupta M, Bhatnagar P, Grover S, Kaur H, Baghel R, Bhasin Y, Chauhan C, Verma B, Manduva V, Mukherjee O, Purushottam M, Sharma A, Jain S, Brahmachari SK, Kukreti R. Gupta M, et al. Pharmacogenomics. 2009 Mar;10(3):385-97. doi: 10.2217/14622416.10.3.385. Pharmacogenomics. 2009. PMID: 19290789
AIM: We investigated the catechol-O-methyltrasferase (COMT) gene, which is a strong functional and positional candidate gene for schizophrenia and therapeutic response to antipsychotic medication. ...Haplotype analysis showed highly signi …
AIM: We investigated the catechol-O-methyltrasferase (COMT) gene, which is a strong functional and positional candidate …
Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls.
Matsuzaka CT, Christofolini D, Ota VK, Gadelha A, Berberian AA, Noto C, Mazzotti DR, Spindola LM, Moretti PN, Smith MAC, Melaragno MI, Belangero SI, Bressan RA. Matsuzaka CT, et al. Braz J Psychiatry. 2017 Oct-Dec;39(4):302-308. doi: 10.1590/1516-4446-2016-1987. Epub 2017 Mar 2. Braz J Psychiatry. 2017. PMID: 28273278 Free PMC article.
It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cognition and dopamine activity in the PFC. Other COMT SNPs could also p …
It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase ( …
Analysis of association between the catechol-O-methyltransferase (COMT) gene and negative symptoms in chronic schizophrenia.
Wang Y, Fang Y, Shen Y, Xu Q. Wang Y, et al. Psychiatry Res. 2010 Sep 30;179(2):147-50. doi: 10.1016/j.psychres.2009.03.029. Epub 2010 May 18. Psychiatry Res. 2010. PMID: 20483479
Negative symptoms commonly seen in chronic schizophrenia are related to prefrontal hypodopaminergia. Dysfunction of the catechol-O-methyltransferase (COMT) gene has long been thought to confer susceptibility to schizophrenia becaus …
Negative symptoms commonly seen in chronic schizophrenia are related to prefrontal hypodopaminergia. Dysfunction of the catechol …
Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.
Diaz-Asper CM, Weinberger DR, Goldberg TE. Diaz-Asper CM, et al. NeuroRx. 2006 Jan;3(1):97-105. doi: 10.1016/j.nurx.2005.12.010. NeuroRx. 2006. PMID: 16490416 Free PMC article. Review.
Catechol-O-methyltransferase (COMT) is a gene involved in the degradation of dopamine and may both increase susceptibility to develop schizophrenia and affect neuronal functions involved in working memory. ...Recently, other single-nucleo …
Catechol-O-methyltransferase (COMT) is a gene involved in the degradation of dopamine and may both increa …
Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia.
Sagud M, Tudor L, Nedic Erjavec G, Nikolac Perkovic M, Uzun S, Mimica N, Madzarac Z, Zivkovic M, Kozumplik O, Konjevod M, Svob Strac D, Pivac N. Sagud M, et al. Genes (Basel). 2023 Jun 27;14(7):1358. doi: 10.3390/genes14071358. Genes (Basel). 2023. PMID: 37510262 Free PMC article.
Catechol-O-methyl transferase (COMT) gene variants are involved in different neuropsychiatric disorders and cognitive impairments, associated with altered dopamine function. ...These findings suggest the sex-specific genotypic and haplotypic associatio …
Catechol-O-methyl transferase (COMT) gene variants are involved in different neuropsychiatric disorders and cognitive i …
Relationship of catechol-O-methyltransferase to schizophrenia and its correlates: evidence for associations and complex interactions.
Lewandowski KE. Lewandowski KE. Harv Rev Psychiatry. 2007 Sep-Oct;15(5):233-44. doi: 10.1080/10673220701650409. Harv Rev Psychiatry. 2007. PMID: 17924258 Review.
Converging lines of evidence suggest that the gene that codes for catechol-O-methyltransferase (COMT) may play a role in the etiology, neurodevelopment, and expression of schizophrenia. ...Additionally, evidence for complex interactions i …
Converging lines of evidence suggest that the gene that codes for catechol-O-methyltransferase (COMT) may …
Association study of catechol-O-methyltransferase gene polymorphisms with schizophrenia and psychopathological symptoms in Han Chinese.
Chen CY, Lu RB, Yeh YW, Shih MC, Huang SY. Chen CY, et al. Genes Brain Behav. 2011 Apr;10(3):316-24. doi: 10.1111/j.1601-183X.2010.00670.x. Epub 2011 Jan 24. Genes Brain Behav. 2011. PMID: 21255265 Free article.
Although dysfunction of catechol-O-methyltransferase (COMT)-mediated dopamine transmission is implicated in the etiology of schizophrenia, the human COMT gene has not been associated consistently with schizophrenia. ...No si …
Although dysfunction of catechol-O-methyltransferase (COMT)-mediated dopamine transmission is implicated in the …
Catechol-O-methyltransferase gene variants may associate with negative symptom response and plasma concentrations of prolactin in schizophrenia after amisulpride treatment.
Chen CY, Yeh YW, Kuo SC, Ho PS, Liang CS, Yen CH, Lu RB, Huang SY. Chen CY, et al. Psychoneuroendocrinology. 2016 Mar;65:67-75. doi: 10.1016/j.psyneuen.2015.12.003. Epub 2015 Dec 8. Psychoneuroendocrinology. 2016. PMID: 26724569
Catechol-O-methyltransferase (COMT) enzyme is involved in the pathogenesis of psychotic symptoms and may be associated with a therapeutic response to antipsychotic drugs. ...A 12-week naturalistic study of amisulpride treatment was carried out in 185 H …
Catechol-O-methyltransferase (COMT) enzyme is involved in the pathogenesis of psychotic symptoms and may be asso …
Association between COMT gene polymorphisms, clinical symptoms, and cognitive functions in Han Chinese patients with schizophrenia.
Sun Z, Zhang Z, Mao P, Ma Y, Li W, Li J, Yang X, Ling S, Tang Y. Sun Z, et al. Psychiatr Genet. 2018 Jun;28(3):47-54. doi: 10.1097/YPG.0000000000000194. Psychiatr Genet. 2018. PMID: 29634613
AIM: Catechol-O-methyltransferase (COMT) gene variants may be involved in the pathogenesis of psychotic symptoms, and associated especially with negative symptom in schizophrenia, but their roles in cognitive function and treatment respon …
AIM: Catechol-O-methyltransferase (COMT) gene variants may be involved in the pathogenesis of psychotic s …
Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex.
Nixon DC, Prust MJ, Sambataro F, Tan HY, Mattay VS, Weinberger DR, Callicott JH. Nixon DC, et al. Biol Psychiatry. 2011 May 15;69(10):1006-8. doi: 10.1016/j.biopsych.2010.10.031. Epub 2011 Jan 7. Biol Psychiatry. 2011. PMID: 21215384
BACKGROUND: Accumulating evidence indicates that genetic polymorphisms of D-amino acid oxidase activator (DAOA) (M24; rs1421292; T-allele) and catechol-O-methyltransferase (COMT) (Val158Met; rs4680) likely enhance susceptibility to schizophrenia …
BACKGROUND: Accumulating evidence indicates that genetic polymorphisms of D-amino acid oxidase activator (DAOA) (M24; rs1421292; T-allele) a …
78 results