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Results: 1 to 20 of 104

1.

Metabolic Clues to Salubrious Longevity in the Brain of the Longest-lived Rodent: the Naked Mole-Rat.

Triplett JC, Swomley A, Kirk J, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Buffenstein R, Butterfield DA.

J Neurochem. 2015 May 5. doi: 10.1111/jnc.13149. [Epub ahead of print]

PMID:
25940666
2.

Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates.

Garbarino VR, Orr ME, Rodriguez KA, Buffenstein R.

Arch Biochem Biophys. 2015 Apr 1. pii: S0003-9861(15)00136-8. doi: 10.1016/j.abb.2015.01.029. [Epub ahead of print] Review.

PMID:
25841340
3.

Regulation of Nrf2 signaling and longevity in naturally long-lived rodents.

Lewis KN, Wason E, Edrey YH, Kristan DM, Nevo E, Buffenstein R.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3722-7. doi: 10.1073/pnas.1417566112. Epub 2015 Mar 9.

PMID:
25775529
4.

Gene expression defines natural changes in mammalian lifespan.

Fushan AA, Turanov AA, Lee SG, Kim EB, Lobanov AV, Yim SH, Buffenstein R, Lee SR, Chang KT, Rhee H, Kim JS, Yang KS, Gladyshev VN.

Aging Cell. 2015 Jun;14(3):352-65. doi: 10.1111/acel.12283. Epub 2015 Feb 9.

5.

Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species.

Pride H, Yu Z, Sunchu B, Mochnick J, Coles A, Zhang Y, Buffenstein R, Hornsby PJ, Austad SN, Pérez VI.

Biochem Biophys Res Commun. 2015 Feb 20;457(4):669-75. doi: 10.1016/j.bbrc.2015.01.046. Epub 2015 Jan 21.

PMID:
25615820
6.

Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent.

Orr ME, Garbarino VR, Salinas A, Buffenstein R.

Neurobiol Aging. 2015 Mar;36(3):1496-504. doi: 10.1016/j.neurobiolaging.2014.12.004. Epub 2014 Dec 12.

PMID:
25576082
7.

Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform.

Buffenstein R, Nelson OL, Corbit KC.

Aging (Albany NY). 2014 Nov;6(11):913-20.

8.

Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice.

Rodriguez KA, Dodds SG, Strong R, Galvan V, Sharp ZD, Buffenstein R.

Front Mol Neurosci. 2014 Nov 4;7:83. doi: 10.3389/fnmol.2014.00083. eCollection 2014.

9.

Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.

Fang X, Seim I, Huang Z, Gerashchenko MV, Xiong Z, Turanov AA, Zhu Y, Lobanov AV, Fan D, Yim SH, Yao X, Ma S, Yang L, Lee SG, Kim EB, Bronson RT, Šumbera R, Buffenstein R, Zhou X, Krogh A, Park TJ, Zhang G, Wang J, Gladyshev VN.

Cell Rep. 2014 Sep 11;8(5):1354-64. doi: 10.1016/j.celrep.2014.07.030. Epub 2014 Aug 28.

10.

A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition.

Rodriguez KA, Osmulski PA, Pierce A, Weintraub ST, Gaczynska M, Buffenstein R.

Biochim Biophys Acta. 2014 Nov;1842(11):2060-72. doi: 10.1016/j.bbadis.2014.07.005. Epub 2014 Jul 10.

PMID:
25018089
11.

And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat.

Grimes KM, Reddy AK, Lindsey ML, Buffenstein R.

Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H284-91. doi: 10.1152/ajpheart.00305.2014. Epub 2014 Jun 6.

PMID:
24906918
12.

The first international mini-symposium on methionine restriction and lifespan.

Ables GP, Brown-Borg HM, Buffenstein R, Church CD, Elshorbagy AK, Gladyshev VN, Huang TH, Miller RA, Mitchell JR, Richie JP, Rogina B, Stipanuk MH, Orentreich DS, Orentreich N.

Front Genet. 2014 May 9;5:122. doi: 10.3389/fgene.2014.00122. eCollection 2014.

13.

Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.

Orr ME, Salinas A, Buffenstein R, Oddo S.

Neurobiol Aging. 2014 Jun;35(6):1233-42. doi: 10.1016/j.neurobiolaging.2013.12.006. Epub 2013 Dec 14.

PMID:
24411482
14.

Cardiac function of the naked mole-rat: ecophysiological responses to working underground.

Grimes KM, Voorhees A, Chiao YA, Han HC, Lindsey ML, Buffenstein R.

Am J Physiol Heart Circ Physiol. 2014 Mar 1;306(5):H730-7. doi: 10.1152/ajpheart.00831.2013. Epub 2013 Dec 20.

15.

Oxidative damage and amyloid-β metabolism in brain regions of the longest-lived rodents.

Edrey YH, Oddo S, Cornelius C, Caccamo A, Calabrese V, Buffenstein R.

J Neurosci Res. 2014 Feb;92(2):195-205. doi: 10.1002/jnr.23320. Epub 2013 Nov 22.

PMID:
24273049
16.

Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination.

Hamilton RT, Bhattacharya A, Walsh ME, Shi Y, Wei R, Zhang Y, Rodriguez KA, Buffenstein R, Chaudhuri AR, Van Remmen H.

PLoS One. 2013 Jun 4;8(6):e65725. doi: 10.1371/journal.pone.0065725. Print 2013.

17.

Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease.

Edrey YH, Medina DX, Gaczynska M, Osmulski PA, Oddo S, Caccamo A, Buffenstein R.

Neurobiol Aging. 2013 Oct;34(10):2352-60. doi: 10.1016/j.neurobiolaging.2013.03.032. Epub 2013 Apr 22.

PMID:
23618870
18.

Elevated protein carbonylation and oxidative stress do not affect protein structure and function in the long-living naked-mole rat: a proteomic approach.

De Waal EM, Liang H, Pierce A, Hamilton RT, Buffenstein R, Chaudhuri AR.

Biochem Biophys Res Commun. 2013 May 17;434(4):815-9. doi: 10.1016/j.bbrc.2013.04.019. Epub 2013 Apr 22.

PMID:
23618867
19.

Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.

Shi Y, Pulliam DA, Liu Y, Hamilton RT, Jernigan AL, Bhattacharya A, Sloane LB, Qi W, Chaudhuri A, Buffenstein R, Ungvari Z, Austad SN, Van Remmen H.

Am J Physiol Regul Integr Comp Physiol. 2013 Mar 1;304(5):R343-55. doi: 10.1152/ajpregu.00139.2012. Epub 2013 Jan 16.

20.

The naked mole-rat response to oxidative stress: just deal with it.

Lewis KN, Andziak B, Yang T, Buffenstein R.

Antioxid Redox Signal. 2013 Oct 20;19(12):1388-99. doi: 10.1089/ars.2012.4911. Epub 2012 Dec 7. Review.

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