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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1939 2
1940 2
1945 1
1946 5
1947 8
1948 4
1949 5
1950 13
1951 12
1952 11
1953 11
1954 25
1955 10
1956 8
1957 9
1958 8
1959 5
1960 7
1961 19
1962 7
1963 28
1964 46
1965 40
1966 49
1967 64
1968 95
1969 106
1970 121
1971 123
1972 156
1973 144
1974 168
1975 185
1976 169
1977 124
1978 141
1979 154
1980 172
1981 188
1982 172
1983 209
1984 234
1985 279
1986 307
1987 252
1988 283
1989 298
1990 324
1991 373
1992 359
1993 402
1994 407
1995 370
1996 378
1997 388
1998 430
1999 447
2000 443
2001 453
2002 483
2003 462
2004 594
2005 648
2006 757
2007 746
2008 793
2009 878
2010 918
2011 954
2012 1033
2013 1108
2014 1184
2015 1185
2016 1213
2017 1286
2018 1163
2019 1200
2020 1300
2021 1351
2022 1222
2023 1157
2024 318

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28,409 results

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Page 1
Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches.
Kellar D, Craft S. Kellar D, et al. Lancet Neurol. 2020 Sep;19(9):758-766. doi: 10.1016/S1474-4422(20)30231-3. Epub 2020 Jul 27. Lancet Neurol. 2020. PMID: 32730766 Free PMC article. Review.
Although the role of insulin in the periphery is well understood, less is known about its multifactorial role in the brain. ...Insulin also modulates vascular function through effects on vasoreactivity, lipid metabolism, and inflammation. ...
Although the role of insulin in the periphery is well understood, less is known about its multifactorial role in the brain. .. …
Insulin action in the brain: cell types, circuits, and diseases.
Chen W, Cai W, Hoover B, Kahn CR. Chen W, et al. Trends Neurosci. 2022 May;45(5):384-400. doi: 10.1016/j.tins.2022.03.001. Epub 2022 Mar 28. Trends Neurosci. 2022. PMID: 35361499 Free PMC article. Review.
The brain is among the targets of insulin action, and insulin resistance is a major contributor to many diseases, including brain disorders. Here, we summarize key roles of insulin action in the brain and how this involves different br
The brain is among the targets of insulin action, and insulin resistance is a major contributor to many diseases, inclu …
Insulin action in the brain regulates both central and peripheral functions.
Agrawal R, Reno CM, Sharma S, Christensen C, Huang Y, Fisher SJ. Agrawal R, et al. Am J Physiol Endocrinol Metab. 2021 Jul 1;321(1):E156-E163. doi: 10.1152/ajpendo.00642.2020. Epub 2021 May 31. Am J Physiol Endocrinol Metab. 2021. PMID: 34056920 Free PMC article. Review.
The brain has been traditionally thought to be insensitive to insulin, primarily because insulin does not stimulate glucose uptake/metabolism in the brain (as it does in classic insulin-sensitive tissues such as muscle, liver, and fat). ...Decre …
The brain has been traditionally thought to be insensitive to insulin, primarily because insulin does not stimulate glu …
Brain insulin resistance and cognitive function: influence of exercise.
Malin SK, Stewart NR, Ude AA, Alderman BL. Malin SK, et al. J Appl Physiol (1985). 2022 Dec 1;133(6):1368-1380. doi: 10.1152/japplphysiol.00375.2022. Epub 2022 Oct 21. J Appl Physiol (1985). 2022. PMID: 36269295 Free PMC article. Review.
In fact, brain insulin signaling is also involved in processes that support healthy cognition. ...Herein, we provide an overview of brain insulin sensitivity in relation to cognitive function from animal and human studies, with particular emphasis plac …
In fact, brain insulin signaling is also involved in processes that support healthy cognition. ...Herein, we provide an overvi …
Origins of Brain Insulin and Its Function.
Nakabeppu Y. Nakabeppu Y. Adv Exp Med Biol. 2019;1128:1-11. doi: 10.1007/978-981-13-3540-2_1. Adv Exp Med Biol. 2019. PMID: 31062322 Review.
Whole-body energy and glucose homeostasis in the periphery of the human body are regulated by insulin, while the brain had been considered as an "insulin-insensitive" organ, because bulk brain glucose uptake is not affected by insulin in either …
Whole-body energy and glucose homeostasis in the periphery of the human body are regulated by insulin, while the brain had bee …
Insulin and the brain.
Derakhshan F, Toth C. Derakhshan F, et al. Curr Diabetes Rev. 2013 Mar 1;9(2):102-16. Curr Diabetes Rev. 2013. PMID: 23231032 Review.
The brain is now regarded as an insulin-sensitive organ with widespread, yet selective, expression of the insulin receptor in the olfactory bulb, hypothalamus, hippocampus, cerebellum, amygdala and cerebral cortex. ...We review the multiple roles of insuli
The brain is now regarded as an insulin-sensitive organ with widespread, yet selective, expression of the insulin recep …
Brain insulin, insulin-like growth factor 1 and glucagon-like peptide 1 signalling in Alzheimer's disease.
Ferreira ST. Ferreira ST. J Neuroendocrinol. 2021 Apr;33(4):e12959. doi: 10.1111/jne.12959. Epub 2021 Mar 19. J Neuroendocrinol. 2021. PMID: 33739563 Review.
Although the brain was once considered an insulin-independent organ, insulin signalling is now recognised as being central to neuronal health and to the function of synapses and brain circuits. Defective brain insulin signalling, as well …
Although the brain was once considered an insulin-independent organ, insulin signalling is now recognised as being cent …
Untangling the effect of insulin action on brain mitochondria and metabolism.
Schell M, Wardelmann K, Kleinridders A. Schell M, et al. J Neuroendocrinol. 2021 Apr;33(4):e12932. doi: 10.1111/jne.12932. Epub 2021 Jan 28. J Neuroendocrinol. 2021. PMID: 33506556 Review.
The regulation of energy homeostasis is controlled by the brain and, besides requiring high amounts of energy, it relies on functional insulin/insulin-like growth factor (IGF)-1 signalling in the central nervous system. ...This review aims to determine the ef …
The regulation of energy homeostasis is controlled by the brain and, besides requiring high amounts of energy, it relies on functiona …
The consequences of hypoglycaemia.
Amiel SA. Amiel SA. Diabetologia. 2021 May;64(5):963-970. doi: 10.1007/s00125-020-05366-3. Epub 2021 Feb 7. Diabetologia. 2021. PMID: 33550443 Free PMC article. Review.
Hypoglycaemia (blood glucose concentration below the normal range) has been recognised as a complication of insulin treatment from the very first days of the discovery of insulin, and remains a major concern for people with diabetes, their families and healthcare pr …
Hypoglycaemia (blood glucose concentration below the normal range) has been recognised as a complication of insulin treatment from th …
Broadening the definition of brain insulin resistance in aging and Alzheimer's disease.
Frazier HN, Ghoweri AO, Anderson KL, Lin RL, Porter NM, Thibault O. Frazier HN, et al. Exp Neurol. 2019 Mar;313:79-87. doi: 10.1016/j.expneurol.2018.12.007. Epub 2018 Dec 18. Exp Neurol. 2019. PMID: 30576640 Free PMC article. Review.
It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of insulin receptors in neurons and glia, the presence of circulating brain insulin, and even localized insulin produ …
It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of …
28,409 results
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