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2000 1
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Page 1
Effect of bosentan upon pulmonary hypertension in chronic obstructive pulmonary disease.
Valerio G, Bracciale P, Grazia D'Agostino A. Valerio G, et al. Ther Adv Respir Dis. 2009 Feb;3(1):15-21. doi: 10.1177/1753465808103499. Ther Adv Respir Dis. 2009. PMID: 19293199 Free article. Clinical Trial.
BACKGROUND: Pulmonary hypertension (PH) in chronic obstructive pulmonary disease [COPD] is mainly determined by hypoxemia under respiratory failure by means of the functional hypoxemic vasoconstrictor response. ...Our aim is to assess the …
BACKGROUND: Pulmonary hypertension (PH) in chronic obstructive pulmonary disease [COPD] is mainly …
Potential Role of CT Metrics in Chronic Obstructive Pulmonary Disease with Pulmonary Hypertension.
Ando K, Kuraishi H, Nagaoka T, Tsutsumi T, Hoshika Y, Kimura T, Ienaga H, Morio Y, Takahashi K. Ando K, et al. Lung. 2015 Dec;193(6):911-8. doi: 10.1007/s00408-015-9813-8. Epub 2015 Oct 9. Lung. 2015. PMID: 26453478
PURPOSE: Recent imaging studies demonstrated the usefulness of quantitative computed tomographic (CT) analysis assessing pulmonary hypertension (PH) in patients with chronic obstructive lung disease (COPD-PH). The aim of this study was to …
PURPOSE: Recent imaging studies demonstrated the usefulness of quantitative computed tomographic (CT) analysis assessing pulmonary …
Clinical course of COPD patients with exercise-induced elevation of pulmonary artery pressure or less severe pulmonary hypertension presenting with respiratory symptoms and the impact of bosentan intervention-prospective, single-center, randomized, parallel-group study.
Kashiwada T, Tanaka Y, Tanaka T, Okano T, Saito Y, Seike M, Hino M, Kimura H, Gemma A. Kashiwada T, et al. BMC Pulm Med. 2024 Feb 17;24(1):90. doi: 10.1186/s12890-024-02895-0. BMC Pulm Med. 2024. PMID: 38368315 Free PMC article. Clinical Trial.
BACKGROUND: The data on bosentan were lacking for the treatment of exercise-induced elevation of pulmonary artery pressure (eePAP) or less severe PH in COPD. This study was conducted to investigate long-term efficacy and safety of bosentan for the treatment o …
BACKGROUND: The data on bosentan were lacking for the treatment of exercise-induced elevation of pulmonary artery pressure (ee …
Endothelial dysfunction in the pulmonary vascular bed.
Chen YF, Oparil S. Chen YF, et al. Am J Med Sci. 2000 Oct;320(4):223-32. doi: 10.1097/00000441-200010000-00001. Am J Med Sci. 2000. PMID: 11061346 Review.
Abnormalities in EDCF and EDRF generation have been demonstrated in a number of cardiopulmonary disease states, such as primary and secondary pulmonary hypertension, chronic obstructive lung disease, cardiopulmonary bypass, and con …
Abnormalities in EDCF and EDRF generation have been demonstrated in a number of cardiopulmonary disease states, such as primary and s …
Desperate Times, Desperate Measures: The Case for RRx-001 in the Treatment of COVID-19.
Oronsky B, Knox S, Cabrales P, Oronsky A, Reid TR. Oronsky B, et al. Semin Oncol. 2020 Oct;47(5):305-308. doi: 10.1053/j.seminoncol.2020.07.002. Epub 2020 Jul 7. Semin Oncol. 2020. PMID: 32718560 Free PMC article.
During the course of these clinical trials it was noted that the rate of chronic obstructive pulmonary disease exacerbation and pneumonia in actively smoking small cell lung cancer patients treated with RRx-001 is less than 1%. Due to extensive …
During the course of these clinical trials it was noted that the rate of chronic obstructive pulmonary disease e …
Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries.
Milara J, Gabarda E, Juan G, Ortiz JL, Guijarro R, Martorell M, Morcillo EJ, Cortijo J. Milara J, et al. Eur Respir J. 2012 Apr;39(4):927-38. doi: 10.1183/09031936.00021411. Epub 2011 Aug 4. Eur Respir J. 2012. PMID: 21828025 Free article.
The endothelin (ET) system contributes to lung vascular tension and remodelling in smokers and chronic obstructive pulmonary disease (COPD) patients. ...These data may be of potential value to explain therapeutic effects of bosentan in so …
The endothelin (ET) system contributes to lung vascular tension and remodelling in smokers and chronic obstructive p …
Inflammatory responses of airway smooth muscle cells and effects of endothelin receptor antagonism.
Knobloch J, Lin Y, Konradi J, Jungck D, Behr J, Strauch J, Stoelben E, Koch A. Knobloch J, et al. Am J Respir Cell Mol Biol. 2013 Jul;49(1):114-27. doi: 10.1165/rcmb.2012-0287OC. Am J Respir Cell Mol Biol. 2013. PMID: 23590298
Endothelin receptor antagonists (ETRAs), authorized for pulmonary hypertension, have failed to prove their utility in chronic lung diseases with corticosteroid-resistant airway inflammation when applied at late disease stages with emphyse …
Endothelin receptor antagonists (ETRAs), authorized for pulmonary hypertension, have failed to prove their utility in chron …
A randomised, controlled trial of bosentan in severe COPD.
Stolz D, Rasch H, Linka A, Di Valentino M, Meyer A, Brutsche M, Tamm M. Stolz D, et al. Eur Respir J. 2008 Sep;32(3):619-28. doi: 10.1183/09031936.00011308. Epub 2008 Apr 30. Eur Respir J. 2008. PMID: 18448495 Free article. Clinical Trial.
Pulmonary hypertension during exercise is common in severe chronic obstructive pulmonary disease (COPD). ...In contrast, arterial oxygen pressure dropped, the alveolar-arterial gradient increased and quality of life deteriorated significa …
Pulmonary hypertension during exercise is common in severe chronic obstructive pulmonary disease ( …
Chronic thromboembolic pulmonary hypertension as a cause of dyspnoea in an older patient with a complex history.
Kähler CM. Kähler CM. Eur Respir Rev. 2009 Sep;18(113):170-3. doi: 10.1183/09059180.00003409. Eur Respir Rev. 2009. PMID: 20956138 Free article.
This case study describes how a full work-up identified chronic thromboembolic PH (CTEPH) as the cause of dyspnoea in a 68-yr-old male with a history of pulmonary embolism and an original diagnosis of chronic obstructive pulmonary disease …
This case study describes how a full work-up identified chronic thromboembolic PH (CTEPH) as the cause of dyspnoea in a 68-yr-old mal …
13 results