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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1988 1
1990 1
1991 6
1992 3
1993 6
1994 11
1995 15
1996 22
1997 35
1998 41
1999 60
2000 73
2001 71
2002 67
2003 45
2004 43
2005 36
2006 43
2007 46
2008 43
2009 44
2010 39
2011 55
2012 42
2013 53
2014 48
2015 38
2016 50
2017 29
2018 33
2019 40
2020 34
2021 31
2022 27
2023 15
2024 5

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1,188 results

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Page 1
Plasma Human Immunodeficiency Virus 1 RNA and CD4+ T-Cell Counts Are Determinants of Virological Nonsuppression Outcomes With Initial Integrase Inhibitor-Based Regimens: A Prospective RESPOND Cohort Study.
Álvarez H, Mocroft A, Ryom L, Neesgaard B, Edwards S, Svedhem V, Günthard HF, Zangerle R, Smith C, Castagna A, d'Arminio Monforte A, Wit F, Stecher M, Lehman C, Mussini C, Fontas E, González E, Wasmuth JC, Sönnerborg A, De Wit S, Chkhartishvili N, Stephan C, Petoumenos K, Jaschinski N, Vannappagari V, Gallant J, Young L, Volny Anne A, Greenberg L, Martín-Iguacel R, Poveda E, Llibre JM; RESPOND (International Cohort Consortium of Infectious Diseases) Study Group. Álvarez H, et al. Clin Infect Dis. 2023 Aug 22;77(4):593-605. doi: 10.1093/cid/ciad219. Clin Infect Dis. 2023. PMID: 37052343 Free PMC article.
At 48 weeks, Kaplan-Meier estimates of rates were 9.6% for viral blips, 2.1% for LLV, 22.2% for RV, and 2.1% for VF. Baseline HIV-1 RNA levels >100 000 copies/mL and CD4+ T-cell counts 200/L were negatively associated with VS at weeks 48 (adjusted odds ratio, 0.5 …
At 48 weeks, Kaplan-Meier estimates of rates were 9.6% for viral blips, 2.1% for LLV, 22.2% for RV, and 2.1% for VF. Baseline HIV-1 …
Intracellular HIV-1 RNA and CD4+ T-cell activation in patients starting antiretrovirals.
El-Diwany R, Breitwieser FP, Soliman M, Skaist AM, Srikrishna G, Blankson JN, Ray SC, Wheelan SJ, Thomas DL, Balagopal A. El-Diwany R, et al. AIDS. 2017 Jun 19;31(10):1405-1414. doi: 10.1097/QAD.0000000000001480. AIDS. 2017. PMID: 28358734 Free PMC article.
DESIGN: Clinical trial (NCT01285050). METHODS: Next-generation sequencing was used to study total RNA from activated CD4 T cells (CD38 and human leukocyte antigen - antigen D related (HLA-DR) expressing) collected from 19 treatment-naive HIV-1/hepatitis C virus-infe …
DESIGN: Clinical trial (NCT01285050). METHODS: Next-generation sequencing was used to study total RNA from activated CD4 T cells (CD3 …
Symptomatic cerebrospinal fluid escape.
Mastrangelo A, Turrini F, de Zan V, Caccia R, Gerevini S, Cinque P. Mastrangelo A, et al. AIDS. 2019 Dec 1;33 Suppl 2:S159-S169. doi: 10.1097/QAD.0000000000002266. AIDS. 2019. PMID: 31789816 Review.
: Cerebrospinal fluid (CSF) viral escape is defined by detectable HIV-RNA in CSF despite undetectable or lower-than-CSF level in plasma of patients receiving combination antiretroviral therapy (cART). ...Brain MRI usually shows diffuse white matter hyperinten …
: Cerebrospinal fluid (CSF) viral escape is defined by detectable HIV-RNA in CSF despite undetectable or lower-than-CSF level …
CD8(+) Cytotoxic T Lymphocyte Responses and Viral Epitope Escape in Acute HIV-1 Infection.
Kim J, De La Cruz J, Lam K, Ng H, Daar ES, Balamurugan A, Yang OO. Kim J, et al. Viral Immunol. 2018 Sep;31(7):525-536. doi: 10.1089/vim.2018.0040. Epub 2018 Jul 30. Viral Immunol. 2018. PMID: 30059271 Free PMC article.
Epitope escape from HIV-1-targeted CD8(+) cytotoxic T lymphocyte (CTL) responses occurs rapidly after acute infection and contributes to the eventual failure of effective immune control of HIV-1 infection. ...HIV-1-specific CD8(+) T ly …
Epitope escape from HIV-1-targeted CD8(+) cytotoxic T lymphocyte (CTL) responses occurs rapidly after acute infection a …
Viral and host mediators of non-suppressible HIV-1 viremia.
Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Crain CR, Traunbauer AK, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, Giguel F, Lian X, Deo R, Gillespie E, Chishti R, Abrha S, Adams T, Siagian A, Dorazio D, Anderson PL, Deeks SG, Lederman MM, Yawetz S, Kuritzkes DR, Lichterfeld MD, Sieg S, Tsibris A, Carrington M, Brumme ZL, Castillo-Mancilla JR, Engelman AN, Gaiha GD, Li JZ. Mohammadi A, et al. Nat Med. 2023 Dec;29(12):3212-3223. doi: 10.1038/s41591-023-02611-1. Epub 2023 Nov 13. Nat Med. 2023. PMID: 37957382 Free PMC article.
Unraveling the mechanisms behind NSV would broaden our understanding of HIV-1 persistence. Here we analyzed plasma virus sequences in eight ART-treated individuals with NSV (88% male) and show that they are composed of large clones without evidence of viral evolutio …
Unraveling the mechanisms behind NSV would broaden our understanding of HIV-1 persistence. Here we analyzed plasma virus seque …
HIV evolution and diversity in ART-treated patients.
van Zyl G, Bale MJ, Kearney MF. van Zyl G, et al. Retrovirology. 2018 Jan 30;15(1):14. doi: 10.1186/s12977-018-0395-4. Retrovirology. 2018. PMID: 29378595 Free PMC article. Review.
Characterizing HIV genetic diversity and evolution during antiretroviral therapy (ART) provides insights into the mechanisms that maintain the viral reservoir during ART. ...Studies on HIV diversity may reveal targets that can be exploited in efforts to eradicate or …
Characterizing HIV genetic diversity and evolution during antiretroviral therapy (ART) provides insights into the mechanisms that mai …
HIV RNA suppression and immune restoration: can we do better?
Pinzone MR, Di Rosa M, Cacopardo B, Nunnari G. Pinzone MR, et al. Clin Dev Immunol. 2012;2012:515962. doi: 10.1155/2012/515962. Epub 2012 Mar 25. Clin Dev Immunol. 2012. PMID: 22489250 Free PMC article. Review.
A crucial element affecting immune recovery is immune activation, related to residual viremia; indeed, a suboptimal virological control (i.e., low levels of plasma HIV RNA) has been related with higher levels of chronic inflammation and all-cause mortality. T …
A crucial element affecting immune recovery is immune activation, related to residual viremia; indeed, a suboptimal virological control (i.e …
Discordance between HIV-1 Population in Plasma at Rebound after Structured Treatment Interruption and Archived Provirus Population in Peripheral Blood Mononuclear Cells.
Hendricks CM, Cash MN, Tagliamonte MS, Riva A, Brander C, Llano A, Salemi M, Stevenson M, Mavian C. Hendricks CM, et al. Microbiol Spectr. 2022 Aug 31;10(4):e0135322. doi: 10.1128/spectrum.01353-22. Epub 2022 Jun 14. Microbiol Spectr. 2022. PMID: 35699458 Free PMC article.
We performed next-generation sequencing (NGS) on cell-associated viral DNA and cell-free virus to understand the interrelationship between sequential ATIs as well as the relationship between viral genomes in circulating peripheral blood mononuclear cells (PBMCs) and RNA …
We performed next-generation sequencing (NGS) on cell-associated viral DNA and cell-free virus to understand the interrelationship between s …
Changes in blood CD8+ lymphocyte activation status and plasma HIV RNA levels during antiretroviral therapy.
Bouscarat F, Levacher M, Landman R, Muffat-Joly M, Girard PM, Saimot AG, Brun-Vézinet F, Sinet M. Bouscarat F, et al. AIDS. 1998 Jul 30;12(11):1267-73. doi: 10.1097/00002030-199811000-00007. AIDS. 1998. PMID: 9708405
OBJECTIVE: To analyse the relationship between CD8+ lymphocyte phenotype alterations and plasma HIV RNA levels in HIV-infected patients treated with the zidovudine-didanosine combination. ...RESULTS: Patients were divided into three categories accordin …
OBJECTIVE: To analyse the relationship between CD8+ lymphocyte phenotype alterations and plasma HIV RNA levels in HI …
Fostemsavir: a new CD4 attachment inhibitor.
Cahn P, Fink V, Patterson P. Cahn P, et al. Curr Opin HIV AIDS. 2018 Jul;13(4):341-345. doi: 10.1097/COH.0000000000000469. Curr Opin HIV AIDS. 2018. PMID: 29771694 Review.
RECENT FINDINGS: Fostemsavir (FTR) is an attachment inhibitor, active regardless of viral tropism, without cross-resistance to any of the existing ARV compounds. A phase 3 study showed a reduction in plasma viral RNA of 1.21-1.73 log10 copies/ml from baseline after …
RECENT FINDINGS: Fostemsavir (FTR) is an attachment inhibitor, active regardless of viral tropism, without cross-resistance to any of the ex …
1,188 results