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Items: 1 to 20 of 84

1.

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response.

Hourihan JM, Moronetti Mazzeo LE, Fernández-Cárdenas LP, Blackwell TK.

Mol Cell. 2016 Aug 18;63(4):553-66. doi: 10.1016/j.molcel.2016.07.019.

PMID:
27540856
2.

Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf.

Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M.

Sci Rep. 2016 Feb 22;6:21611. doi: 10.1038/srep21611.

3.

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.

Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M.

Free Radic Biol Med. 2015 Nov;88(Pt B):290-301. doi: 10.1016/j.freeradbiomed.2015.06.008. Epub 2015 Aug 5. Review.

PMID:
26232625
4.

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence.

Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, Raghavan P, Operaña TN, Esmaillie R, Blackwell TK.

Elife. 2015 Aug 24;4. doi: 10.7554/eLife.07836.

5.

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.

Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK.

Nature. 2015 Mar 5;519(7541):97-101. doi: 10.1038/nature14021. Epub 2014 Dec 15.

6.

Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism.

Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK.

Aging Cell. 2014 Dec;13(6):1075-85. doi: 10.1111/acel.12273. Epub 2014 Sep 25.

7.

mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity.

Mizunuma M, Neumann-Haefelin E, Moroz N, Li Y, Blackwell TK.

Aging Cell. 2014 Oct;13(5):869-78. doi: 10.1111/acel.12248. Epub 2014 Jul 9.

8.

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3781-6. doi: 10.1073/pnas.1400705111. Epub 2014 Feb 20.

9.

Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf.

Glover-Cutter KM, Lin S, Blackwell TK.

PLoS Genet. 2013;9(9):e1003701. doi: 10.1371/journal.pgen.1003701. Epub 2013 Sep 12.

10.

TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development.

Ruf V, Holzem C, Peyman T, Walz G, Blackwell TK, Neumann-Haefelin E.

Dev Biol. 2013 Dec 15;384(2):214-27. doi: 10.1016/j.ydbio.2013.08.011. Epub 2013 Aug 20.

11.

Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans.

Ishikado A, Sono Y, Matsumoto M, Robida-Stubbs S, Okuno A, Goto M, King GL, Blackwell TK, Makino T.

Free Radic Biol Med. 2013 Dec;65:1506-15. doi: 10.1016/j.freeradbiomed.2012.12.006. Epub 2012 Dec 28.

12.

Mitochondrial SKN-1/Nrf mediates a conserved starvation response.

Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran SP.

Cell Metab. 2012 Oct 3;16(4):526-37. doi: 10.1016/j.cmet.2012.09.007.

13.

Role of microRNA processing in adipose tissue in stress defense and longevity.

Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR.

Cell Metab. 2012 Sep 5;16(3):336-47. doi: 10.1016/j.cmet.2012.07.017.

14.

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK.

Cell Metab. 2012 May 2;15(5):713-24. doi: 10.1016/j.cmet.2012.04.007.

15.

Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity.

Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK.

PLoS Genet. 2011 Jun;7(6):e1002119. doi: 10.1371/journal.pgen.1002119. Epub 2011 Jun 9.

16.

RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.

Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK.

PLoS Genet. 2010 Aug 5;6(8). pii: e1001048. doi: 10.1371/journal.pgen.1001048.

17.

Life is short, if sweet.

Porter Abate J, Blackwell TK.

Cell Metab. 2009 Nov;10(5):338-9. doi: 10.1016/j.cmet.2009.10.006.

18.

Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.

Oliveira RP, Porter Abate J, Dilks K, Landis J, Ashraf J, Murphy CT, Blackwell TK.

Aging Cell. 2009 Sep;8(5):524-41. doi: 10.1111/j.1474-9726.2009.00501.x. Epub 2009 Jul 3.

19.

nhl-2 Modulates microRNA activity in Caenorhabditis elegans.

Hammell CM, Lubin I, Boag PR, Blackwell TK, Ambros V.

Cell. 2009 Mar 6;136(5):926-38. doi: 10.1016/j.cell.2009.01.053.

20.

A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.

Oláhová M, Taylor SR, Khazaipoul S, Wang J, Morgan BA, Matsumoto K, Blackwell TK, Veal EA.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19839-44. doi: 10.1073/pnas.0805507105. Epub 2008 Dec 8.

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