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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1950 2
1952 5
1953 5
1954 3
1955 2
1956 1
1957 2
1959 4
1960 1
1961 1
1962 3
1963 15
1964 25
1965 13
1966 14
1967 14
1968 28
1969 17
1970 25
1971 28
1972 33
1973 38
1974 47
1975 50
1976 24
1977 23
1978 29
1979 41
1980 32
1981 24
1982 38
1983 55
1984 40
1985 58
1986 55
1987 41
1988 53
1989 51
1990 73
1991 56
1992 70
1993 72
1994 74
1995 70
1996 75
1997 76
1998 72
1999 125
2000 133
2001 149
2002 167
2003 170
2004 216
2005 244
2006 343
2007 390
2008 465
2009 451
2010 426
2011 457
2012 563
2013 620
2014 711
2015 692
2016 722
2017 725
2018 770
2019 816
2020 962
2021 977
2022 967
2023 943
2024 344

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12,913 results

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Page 1
Current understanding of bipolar disorder: Toward integration of biological basis and treatment strategies.
Kato T. Kato T. Psychiatry Clin Neurosci. 2019 Sep;73(9):526-540. doi: 10.1111/pcn.12852. Epub 2019 May 23. Psychiatry Clin Neurosci. 2019. PMID: 31021488 Free article. Review.
Biological studies of bipolar disorder initially focused on the mechanism of action for antidepressants and antipsychotic drugs, and the roles of monoamines (e.g., serotonin, dopamine) have been extensively studied. ...Efficacy of anticonvulsants, animal studies of …
Biological studies of bipolar disorder initially focused on the mechanism of action for antidepressants and antipsychotic drug …
Brain age and cognitive functioning in first-episode bipolar disorder.
Chakrabarty T, Frangou S, Torres IJ, Ge R, Yatham LN. Chakrabarty T, et al. Psychol Med. 2023 Aug;53(11):5127-5135. doi: 10.1017/S0033291722002136. Epub 2022 Jul 25. Psychol Med. 2023. PMID: 35875930 Free PMC article.
BACKGROUND: There is significant heterogeneity in cognitive function in patients with bipolar I disorder (BDI); however, there is a dearth of research into biological mechanisms that might underlie cognitive heterogeneity, especially at disease onset. ...CONCLUSION: …
BACKGROUND: There is significant heterogeneity in cognitive function in patients with bipolar I disorder (BDI); however, there …
A systematic review and meta-analysis of structural and functional brain alterations in individuals with genetic and clinical high-risk for psychosis and bipolar disorder.
Luna LP, Radua J, Fortea L, Sugranyes G, Fortea A, Fusar-Poli P, Smith L, Firth J, Shin JI, Brunoni AR, Husain MI, Husian MO, Sair HI, Mendes WO, Uchoa LRA, Berk M, Maes M, Daskalakis ZJ, Frangou S, Fornaro M, Vieta E, Stubbs B, Solmi M, Carvalho AF. Luna LP, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jul 13;117:110540. doi: 10.1016/j.pnpbp.2022.110540. Epub 2022 Feb 28. Prog Neuropsychopharmacol Biol Psychiatry. 2022. PMID: 35240226 Review.
Neuroimaging findings in people at either genetic risk or at clinical high-risk for psychosis (CHR-P) or bipolar disorder (CHR-B) remain unclear. A meta-analytic review of whole-brain voxel-based morphometry (VBM) and functional magnetic resonance imaging (fM …
Neuroimaging findings in people at either genetic risk or at clinical high-risk for psychosis (CHR-P) or bipolar disorder (CHR …
THERAPEUTIC TARGETING OF BRAIN ARACHIDONIC ACID CASCADE IN BIPOLAR DISORDER BY LOW DOSE ASPIRIN AND CELECOXIB.
Rapoport SI, Hibbeln JR. Rapoport SI, et al. Prostaglandins Leukot Essent Fatty Acids. 2020 Aug;159:102118. doi: 10.1016/j.plefa.2020.102118. Epub 2020 May 21. Prostaglandins Leukot Essent Fatty Acids. 2020. PMID: 32505122 Review.
BACKGROUND: Studies in unanesthetized rats suggest that mood stabilizers approved for treating bipolar disorder downregulate brain arachidonic acid (AA) metabolism. ...CONCLUSIONS: Efficacy of both celecoxib and aspirin as adjuncts to mood stabilizers in the …
BACKGROUND: Studies in unanesthetized rats suggest that mood stabilizers approved for treating bipolar disorder downregulate …
Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings.
Scaini G, Valvassori SS, Diaz AP, Lima CN, Benevenuto D, Fries GR, Quevedo J. Scaini G, et al. Braz J Psychiatry. 2020 Sep-Oct;42(5):536-551. doi: 10.1590/1516-4446-2019-0732. Braz J Psychiatry. 2020. PMID: 32267339 Free PMC article. Review.
Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that alternate between mania and hypomania or between depression and mixed states, often associated with functional impairment. ...Despite the advances in the pathophysiological knowl …
Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that alternate between mania and hypomania …
Brain atrophy and cognitive decline in bipolar disorder: Influence of medication use, symptomatology and illness duration.
Degraff Z, Souza GS, Santos NA, Shoshina II, Felisberti FM, Fernandes TP, Sigurdsson G. Degraff Z, et al. J Psychiatr Res. 2023 Jul;163:421-429. doi: 10.1016/j.jpsychires.2023.05.074. Epub 2023 May 26. J Psychiatr Res. 2023. PMID: 37276646
Bipolar disorder (BPD) is a chronic condition characterized by recurrent episodes of mania and depression. ...These differences were pronounced in patients with BPD, motivating further investigations of pathophysiological mechanisms involved in brain atrophy …
Bipolar disorder (BPD) is a chronic condition characterized by recurrent episodes of mania and depression. ...These difference …
Shared and distinct structural brain alterations and cognitive features in drug-naive schizophrenia and bipolar disorder.
Zhang W, Du JL, Fang XY, Ni LY, Zhu YY, Yan W, Lu SP, Zhang RR, Xie SP. Zhang W, et al. Asian J Psychiatr. 2023 Apr;82:103513. doi: 10.1016/j.ajp.2023.103513. Epub 2023 Feb 11. Asian J Psychiatr. 2023. PMID: 36827938
Our study aimed to examine the shared and distinct structural brain alterations, including cortical thickness(CT) and local gyrification index(LGI), and cognitive impairments between the early course stage of drug-naive schizophrenia(SZ) and bipolar disorder( …
Our study aimed to examine the shared and distinct structural brain alterations, including cortical thickness(CT) and local gyrificat …
Brain structural abnormalities at the onset of schizophrenia and bipolar disorder: a meta-analysis of controlled magnetic resonance imaging studies.
De Peri L, Crescini A, Deste G, Fusar-Poli P, Sacchetti E, Vita A. De Peri L, et al. Curr Pharm Des. 2012;18(4):486-94. doi: 10.2174/138161212799316253. Curr Pharm Des. 2012. PMID: 22239579 Review.
A number of structural brain imaging studies and meta-analytic reviews have shown that multiple subtle brain abnormalities are consistently found in schizophrenia and bipolar disorder. ...However, whole grey matter volume deficits and lateral ventricul …
A number of structural brain imaging studies and meta-analytic reviews have shown that multiple subtle brain abnormalities are …
Lithium and the other mood stabilizers effective in bipolar disorder target the rat brain arachidonic acid cascade.
Rapoport SI. Rapoport SI. ACS Chem Neurosci. 2014 Jun 18;5(6):459-67. doi: 10.1021/cn500058v. Epub 2014 May 15. ACS Chem Neurosci. 2014. PMID: 24786695 Free PMC article. Review.
This Review evaluates the arachidonic acid (AA, 20:4n-6) cascade hypothesis for the actions of lithium and other FDA-approved mood stabilizers in bipolar disorder (BD). The hypothesis is based on evidence in unanesthetized rats that chronically administered lithium, …
This Review evaluates the arachidonic acid (AA, 20:4n-6) cascade hypothesis for the actions of lithium and other FDA-approved mood stabilize …
Neuroprogression and illness trajectories in bipolar disorder.
Kapczinski NS, Mwangi B, Cassidy RM, Librenza-Garcia D, Bermudez MB, Kauer-Sant'anna M, Kapczinski F, Passos IC. Kapczinski NS, et al. Expert Rev Neurother. 2017 Mar;17(3):277-285. doi: 10.1080/14737175.2017.1240615. Epub 2016 Oct 3. Expert Rev Neurother. 2017. PMID: 27659841 Review.
The longitudinal course of bipolar disorder is highly variable, and a subset of patients seems to present a progressive course associated with brain changes and functional impairment. ...We also discuss treatment refractoriness that may take place in some cas …
The longitudinal course of bipolar disorder is highly variable, and a subset of patients seems to present a progressive course …
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