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A retrospective review of methotrexate-induced hepatotoxicity among patients with psoriasis in a tertiary dermatology center in Malaysia.
Ng LC, Lee YY, Lee CK, Wong SM. Ng LC, et al. Int J Dermatol. 2013 Jan;52(1):102-5. doi: 10.1111/j.1365-4632.2011.05436.x. Int J Dermatol. 2013. PMID: 23278617 Review.
BACKGROUND: Methotrexate (MTX) is a common and efficacious systemic agent used for the treatment of moderate to severe psoriasis. ...We analyzed patients' demography, serial laboratory investigations, liver ultrasounds, and liver biopsies of pat …
BACKGROUND: Methotrexate (MTX) is a common and efficacious systemic agent used for the treatment of moderate to severe psoriasis …
Prevalence and risk factors of methotrexate hepatoxicity in Asian patients with psoriasis.
Yeo CM, Chong VH, Earnest A, Yang WL. Yeo CM, et al. World J Hepatol. 2013 May 27;5(5):275-80. doi: 10.4254/wjh.v5.i5.275. World J Hepatol. 2013. PMID: 23717738 Free PMC article.
AIM: To establish the prevalence of liver fibrosis and to evaluate the possible risk factors for fibrosis and progression in Asian with psoriasis treated with methotrexate (MTX) based on liver histology. METHODS: Patients with psoriasis t …
AIM: To establish the prevalence of liver fibrosis and to evaluate the possible risk factors for fibrosis and progression in Asian wi …
Risk of liver disease in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis receiving methotrexate: A population-based study.
Gelfand JM, Wan J, Zhang H, Shin DB, Ogdie A, Syed MN, Egeberg A. Gelfand JM, et al. J Am Acad Dermatol. 2021 Jun;84(6):1636-1643. doi: 10.1016/j.jaad.2021.02.019. Epub 2021 Feb 16. J Am Acad Dermatol. 2021. PMID: 33607181
OBJECTIVE: To compare liver disease risk among patients with psoriasis (PsO), psoriatic arthritis (PsA), or RA receiving methotrexate. METHODS: In a population-based cohort study, Danish individuals with PsO, PsA, or RA receiving methotrexate be …
OBJECTIVE: To compare liver disease risk among patients with psoriasis (PsO), psoriatic arthritis (PsA), or RA receiving me …
Assessment and management of methotrexate hepatotoxicity in psoriasis patients: report from a consensus conference to evaluate current practice and identify key questions toward optimizing methotrexate use in the clinic.
Barker J, Horn EJ, Lebwohl M, Warren RB, Nast A, Rosenberg W, Smith C; International Psoriasis Council. Barker J, et al. J Eur Acad Dermatol Venereol. 2011 Jul;25(7):758-64. doi: 10.1111/j.1468-3083.2010.03932.x. Epub 2010 Dec 29. J Eur Acad Dermatol Venereol. 2011. PMID: 21198946 Review.
Experts in psoriasis, hepatology, pharmacokinetics and pharmacogenetics convened to discuss the safety and monitoring of methotrexate with respect to hepatotoxicity when used in the treatment of psoriasis. ...Liver safety monitoring is currently …
Experts in psoriasis, hepatology, pharmacokinetics and pharmacogenetics convened to discuss the safety and monitoring of methotrex …
Assessment of methotrexate hepatotoxicity in psoriasis patients: a prospective evaluation of four serum fibrosis markers.
Chládek J, Simková M, Vanecková J, Hroch M, Vávrová J, Hůlek P. Chládek J, et al. J Eur Acad Dermatol Venereol. 2013 Aug;27(8):1007-14. doi: 10.1111/j.1468-3083.2012.04643.x. Epub 2012 Aug 7. J Eur Acad Dermatol Venereol. 2013. PMID: 22882190
BACKGROUND: Low-dose oral methotrexate (MTX) is an effective immunosuppressive therapy for chronic plaque psoriasis. ...CONCLUSION: The fibrosis markers hyaluronic acid and Hepascore (the multiple test algorithm which includes hyaluronic acid) are less liver …
BACKGROUND: Low-dose oral methotrexate (MTX) is an effective immunosuppressive therapy for chronic plaque psoriasis. ...CONCLU …
Risk-benefit assessment of methotrexate in the treatment of severe psoriasis.
Kuijpers AL, van de Kerkhof PC. Kuijpers AL, et al. Am J Clin Dermatol. 2000 Jan-Feb;1(1):27-39. doi: 10.2165/00128071-200001010-00003. Am J Clin Dermatol. 2000. PMID: 11702302 Review.
Methotrexate is an established and highly effective systemic treatment for severe psoriasis, including the pustular and erythrodermic forms. ...The histological assessment of liver biopsies, according to the international guidelines, remains the gold s …
Methotrexate is an established and highly effective systemic treatment for severe psoriasis, including the pustular and erythr …
A pragmatic non-invasive assessment of liver fibrosis in patients with psoriasis, rheumatoid arthritis or Crohn's disease receiving methotrexate therapy.
Cervoni JP, Alby-Lepresle B, Weil D, Zhong P, Aubin F, Wendling D, Toussirot E, Vuitton L, Carbonnel F, Blondet R, Thévenot T, Calès P, Monnet E, Di Martino V. Cervoni JP, et al. Clin Res Hepatol Gastroenterol. 2020 Jan-Jun;44S:100003. doi: 10.1016/j.clirex.2020.100003. Epub 2020 Feb 8. Clin Res Hepatol Gastroenterol. 2020. PMID: 33602481 Free article.
BACKGROUND AND AIMS: The reported hepatotoxicity of methotrexate underlines the need for a repeated non-invasive and reliable evaluation of liver fibrosis. ...METHODS: Fibrosis was prospectively evaluated using 9 non-invasive tests in consecutive patie …
BACKGROUND AND AIMS: The reported hepatotoxicity of methotrexate underlines the need for a repeated non-invasive and reliable …
Prevalence, characteristics and severity of non-alcoholic fatty liver disease in patients with chronic plaque psoriasis.
Miele L, Vallone S, Cefalo C, La Torre G, Di Stasi C, Vecchio FM, D'Agostino M, Gabrieli ML, Vero V, Biolato M, Pompili M, Gasbarrini G, Rapaccini G, Amerio P, De Simone C, Grieco A. Miele L, et al. J Hepatol. 2009 Oct;51(4):778-86. doi: 10.1016/j.jhep.2009.06.008. Epub 2009 Jun 26. J Hepatol. 2009. PMID: 19664838
Phase 2: Comparison of the psoriasis cohort subgroup with NAFLD and an age- and body mass index-matched retrospective cohort of 125 non-psoriasis patients with biopsy proven NAFLD. ...Routine work-up for NAFLD may be warranted in patients with psoriasis …
Phase 2: Comparison of the psoriasis cohort subgroup with NAFLD and an age- and body mass index-matched retrospective cohort of 125 n …
The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
Lynch M, Higgins E, McCormick PA, Kirby B, Nolan N, Rogers S, Lally A, Vellinga A, Omar H, Collins P. Lynch M, et al. JAMA Dermatol. 2014 Aug;150(8):856-62. doi: 10.1001/jamadermatol.2013.9336. JAMA Dermatol. 2014. PMID: 24964792
IMPORTANCE: There is a need for noninvasive tools to monitor hepatotoxicity in patients with psoriasis who are receiving methotrexate sodium. ...CONCLUSIONS AND RELEVANCE: Transient elastography and FibroTest are effective noninvasive tools for monitoring …
IMPORTANCE: There is a need for noninvasive tools to monitor hepatotoxicity in patients with psoriasis who are receiving me …
Validity of noninvasive markers of methotrexate-induced hepatotoxicity: a retrospective cohort study.
Martyn-Simmons CL, Rosenberg WM, Cross R, Wong T, Smith CH, Barker JN. Martyn-Simmons CL, et al. Br J Dermatol. 2014 Aug;171(2):267-73. doi: 10.1111/bjd.12782. Epub 2014 Jun 18. Br J Dermatol. 2014. PMID: 24942271
BACKGROUND: Methotrexate is a cost-effective systemic treatment for moderate-to-severe psoriasis, but the perceived risk of associated liver fibrosis prevents optimal use. ...METHODS: A retrospective cohort study comparing the diagnostic accuracy of PI …
BACKGROUND: Methotrexate is a cost-effective systemic treatment for moderate-to-severe psoriasis, but the perceived risk of as …
26 results