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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1974 2
1975 1
1979 1
1980 1
1982 1
1983 3
1984 1
1986 5
1987 5
1989 4
1990 6
1991 7
1992 5
1993 5
1994 3
1995 4
1996 4
1997 2
1998 7
1999 6
2000 4
2001 8
2002 5
2003 5
2004 5
2005 7
2006 9
2007 16
2008 23
2009 22
2010 24
2011 45
2012 35
2013 44
2014 45
2015 38
2016 43
2017 42
2018 40
2019 33
2020 41
2021 38
2022 23
2023 21
2024 6

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639 results

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Page 1
Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension.
Rabinovitch M, Guignabert C, Humbert M, Nicolls MR. Rabinovitch M, et al. Circ Res. 2014 Jun 20;115(1):165-75. doi: 10.1161/CIRCRESAHA.113.301141. Circ Res. 2014. PMID: 24951765 Free PMC article. Review.
This review summarizes an expanding body of knowledge indicating that failure to resolve inflammation and altered immune processes underlie the development of pulmonary arterial hypertension. The chemokines and cytokines implicated in pulmonary arte …
This review summarizes an expanding body of knowledge indicating that failure to resolve inflammation and altered immune processes underlie …
Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages.
Yaku A, Inagaki T, Asano R, Okazawa M, Mori H, Sato A, Hia F, Masaki T, Manabe Y, Ishibashi T, Vandenbon A, Nakatsuka Y, Akaki K, Yoshinaga M, Uehata T, Mino T, Morita S, Ishibashi-Ueda H, Morinobu A, Tsujimura T, Ogo T, Nakaoka Y, Takeuchi O. Yaku A, et al. Circulation. 2022 Sep 27;146(13):1006-1022. doi: 10.1161/CIRCULATIONAHA.122.059435. Epub 2022 Aug 23. Circulation. 2022. PMID: 35997026
BACKGROUND: Pulmonary arterial hypertension (PAH) is a type of pulmonary hypertension (PH) characterized by obliterative pulmonary vascular remodeling, resulting in right-sided heart failure. ...RESULTS: ZC3H12A expression in peripheral …
BACKGROUND: Pulmonary arterial hypertension (PAH) is a type of pulmonary hypertension (PH) characterized …
Perivascular Inflammation in Pulmonary Arterial Hypertension.
Hu Y, Chi L, Kuebler WM, Goldenberg NM. Hu Y, et al. Cells. 2020 Oct 22;9(11):2338. doi: 10.3390/cells9112338. Cells. 2020. PMID: 33105588 Free PMC article. Review.
Perivascular inflammation is a prominent pathologic feature in most animal models of pulmonary hypertension (PH) as well as in pulmonary arterial hypertension (PAH) patients. ...Similarly, multiple immune cells, including neutrophils, mac …
Perivascular inflammation is a prominent pathologic feature in most animal models of pulmonary hypertension (PH) as well as in …
Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Gorelova A, Berman M, Al Ghouleh I. Gorelova A, et al. Antioxid Redox Signal. 2021 Apr 20;34(12):891-914. doi: 10.1089/ars.2020.8169. Antioxid Redox Signal. 2021. PMID: 32746619 Free PMC article. Review.
Endothelial-to-mesenchymal transition (EndMT) is a process that encompasses extensive transcriptional reprogramming of activated endothelial cells leading to a shift toward mesenchymal cellular phenotypes and functional responses. ...EndMT is also being progressively impli …
Endothelial-to-mesenchymal transition (EndMT) is a process that encompasses extensive transcriptional reprogramming of activated endothelial …
Mechanisms of disease: pulmonary arterial hypertension.
Schermuly RT, Ghofrani HA, Wilkins MR, Grimminger F. Schermuly RT, et al. Nat Rev Cardiol. 2011 Jun 21;8(8):443-55. doi: 10.1038/nrcardio.2011.87. Nat Rev Cardiol. 2011. PMID: 21691314 Free PMC article. Review.
Our understanding of, and approach to, pulmonary arterial hypertension has undergone a paradigm shift in the past decade. Once a condition thought to be dominated by increased vasoconstrictor tone and thrombosis, pulmonary arterial hypertensi …
Our understanding of, and approach to, pulmonary arterial hypertension has undergone a paradigm shift in the past decad …
Endothelial-to-mesenchymal transition in pulmonary hypertension.
Ranchoux B, Antigny F, Rucker-Martin C, Hautefort A, Péchoux C, Bogaard HJ, Dorfmüller P, Remy S, Lecerf F, Planté S, Chat S, Fadel E, Houssaini A, Anegon I, Adnot S, Simonneau G, Humbert M, Cohen-Kaminsky S, Perros F. Ranchoux B, et al. Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15. Circulation. 2015. PMID: 25593290
BACKGROUND: The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of alpha-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. ...Findin …
BACKGROUND: The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the ac …
Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension.
Masaki T, Okazawa M, Asano R, Inagaki T, Ishibashi T, Yamagishi A, Umeki-Mizushima S, Nishimura M, Manabe Y, Ishibashi-Ueda H, Shirai M, Tsuchimochi H, Pearson JT, Kumanogoh A, Sakata Y, Ogo T, Kishimoto T, Nakaoka Y. Masaki T, et al. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2023899118. doi: 10.1073/pnas.2023899118. Proc Natl Acad Sci U S A. 2021. PMID: 33836606 Free PMC article.
Pulmonary arterial hypertension (PAH) is a devastating disease characterized by arteriopathy in the small to medium-sized distal pulmonary arteries, often accompanied by infiltration of inflammatory cells. ...RNA-seq analysis, chromatin immunopr …
Pulmonary arterial hypertension (PAH) is a devastating disease characterized by arteriopathy in the small to medium-siz …
GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension.
Toyama T, Kudryashova TV, Ichihara A, Lenna S, Looney A, Shen Y, Jiang L, Teos L, Avolio T, Lin D, Kaplan U, Marden G, Dambal V, Goncharov D, Delisser H, Lafyatis R, Seta F, Goncharova EA, Trojanowska M. Toyama T, et al. Sci Rep. 2023 Apr 22;13(1):6593. doi: 10.1038/s41598-023-33779-8. Sci Rep. 2023. PMID: 37087509 Free PMC article.
Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and often death. Here we report that deficiency of transcription factor …
Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by a progressive increase in pul …
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension.
Wang Z, Chen J, Babicheva A, Jain PP, Rodriguez M, Ayon RJ, Ravellette KS, Wu L, Balistrieri F, Tang H, Wu X, Zhao T, Black SM, Desai AA, Garcia JGN, Sun X, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Wang J, Yuan JX. Wang Z, et al. Am J Physiol Cell Physiol. 2021 Dec 1;321(6):C1010-C1027. doi: 10.1152/ajpcell.00147.2021. Epub 2021 Oct 20. Am J Physiol Cell Physiol. 2021. PMID: 34669509 Free PMC article.
Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca(2+) and Na(+) influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung vasculature and its potential pathogenic role in pulmonary arterial …
Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca(2+) and Na(+) influx in multiple types of cells. Littl …
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.
Long L, Ormiston ML, Yang X, Southwood M, Gräf S, Machado RD, Mueller M, Kinzel B, Yung LM, Wilkinson JM, Moore SD, Drake KM, Aldred MA, Yu PB, Upton PD, Morrell NW. Long L, et al. Nat Med. 2015 Jul;21(7):777-85. doi: 10.1038/nm.3877. Epub 2015 Jun 15. Nat Med. 2015. PMID: 26076038 Free PMC article.
Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II) signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH). However, selective targeting of this signaling pathway using BMP ligan …
Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II) signaling in the endothelium as an initiating …
639 results