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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 2
1977 1
1978 2
1979 1
1980 2
1981 2
1983 3
1984 3
1985 1
1986 5
1987 3
1988 3
1989 5
1990 3
1991 9
1992 10
1993 17
1994 15
1995 13
1996 24
1997 25
1998 15
1999 33
2000 24
2001 46
2002 37
2003 48
2004 59
2005 69
2006 70
2007 67
2008 77
2009 85
2010 108
2011 133
2012 168
2013 145
2014 179
2015 191
2016 198
2017 239
2018 291
2019 330
2020 443
2021 546
2022 618
2023 666
2024 351

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Search Results

4,850 results

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Page 1
Strategies to enhance CAR-T persistence.
Liu Y, An L, Huang R, Xiong J, Yang H, Wang X, Zhang X. Liu Y, et al. Biomark Res. 2022 Nov 23;10(1):86. doi: 10.1186/s40364-022-00434-9. Biomark Res. 2022. PMID: 36419115 Free PMC article. Review.
One of the main challenges is the limited persistence of CAR-T cells. To further optimize the clinical effects of CAR-T cells, many studies have focused on modifying the CAR structure and regulating CAR-T cell differentiation. In this review, we focus on CAR-T cell persist …
One of the main challenges is the limited persistence of CAR-T cells. To further optimize the clinical effects of CAR-T cells, many s …
Polymerase chain reaction: basic protocol plus troubleshooting and optimization strategies.
Lorenz TC. Lorenz TC. J Vis Exp. 2012 May 22;(63):e3998. doi: 10.3791/3998. J Vis Exp. 2012. PMID: 22664923 Free PMC article.
PCR failures can become frustrating unless patience and careful troubleshooting are employed to sort out and solve the problem(s). This protocol outlines the basic principles of PCR, provides a methodology that will result in amplification of most target sequences, and pre …
PCR failures can become frustrating unless patience and careful troubleshooting are employed to sort out and solve the problem(s). This prot …
Cell culture media for recombinant protein expression in Chinese hamster ovary (CHO) cells: History, key components, and optimization strategies.
Ritacco FV, Wu Y, Khetan A. Ritacco FV, et al. Biotechnol Prog. 2018 Nov;34(6):1407-1426. doi: 10.1002/btpr.2706. Epub 2018 Oct 5. Biotechnol Prog. 2018. PMID: 30290072 Review.
Such media must support high viable cell densities while also stimulating the synthesis and extracellular transport of biologic products. Early media development efforts in this area yielded basic formulations to sustain growth, viability, and cellular function, albeit com …
Such media must support high viable cell densities while also stimulating the synthesis and extracellular transport of biologic products. Ea …
Nutritional Considerations and Strategies to Facilitate Injury Recovery and Rehabilitation.
Smith-Ryan AE, Hirsch KR, Saylor HE, Gould LM, Blue MNM. Smith-Ryan AE, et al. J Athl Train. 2020 Sep 1;55(9):918-930. doi: 10.4085/1062-6050-550-19. J Athl Train. 2020. PMID: 32991705 Free PMC article.
Nutritional interventions may augment the recovery process and support optimal healing; therefore, incorporating nutritional strategies is important at each stage of the healing process. ...In this article, we address best practices for implementing nutritional s …
Nutritional interventions may augment the recovery process and support optimal healing; therefore, incorporating nutritional strat …
[Small animal cardiopulmonary -resuscitation (CPR) in general practice].
Hoehne SN, Kruppert A, Boller M. Hoehne SN, et al. Schweiz Arch Tierheilkd. 2020 Dec;162(12):735-753. doi: 10.17236/sat00280. Schweiz Arch Tierheilkd. 2020. PMID: 33263542 Free article. Review. German.
Cardiopulmonary resuscitation (CPR) is the only available treatment for CPA and several opportunities exist to improve the veterinary team's resuscitation approach and optimize small animal CPR patient outcomes. In 2012, the Reassessment Campaign on Veterinary Resuscitatio …
Cardiopulmonary resuscitation (CPR) is the only available treatment for CPA and several opportunities exist to improve the veterinary team's …
Whole Mount Immunohistochemistry in Zebrafish Embryos and Larvae.
Hammond-Weinberger DR, ZeRuth GT. Hammond-Weinberger DR, et al. J Vis Exp. 2020 Jan 29;(155). doi: 10.3791/60575. J Vis Exp. 2020. PMID: 32065134
Immunohistochemistry is a widely used technique to explore protein expression and localization during both normal developmental and disease states. Although many immunohistochemistry protocols have been optimized for mammalian tissue and tissue sections, these protocols of …
Immunohistochemistry is a widely used technique to explore protein expression and localization during both normal developmental and disease …
Increase recombinant antibody yields through optimizing vector design and production process in CHO cells.
Yang Y, Li Z, Li Q, Ma K, Lin Y, Feng H, Wang T. Yang Y, et al. Appl Microbiol Biotechnol. 2022 Aug;106(13-16):4963-4975. doi: 10.1007/s00253-022-12051-5. Epub 2022 Jul 5. Appl Microbiol Biotechnol. 2022. PMID: 35788878
In the present study, we first expressed recombinant adalimumab through combination of the vector design and production process optimization in CHO cells. Bicistronic vector, monocistronic vector, and dual promoter vector were constructed, and the production process was …
In the present study, we first expressed recombinant adalimumab through combination of the vector design and production process optimizat …
Supramolecular Energy Materials.
Dumele O, Chen J, Passarelli JV, Stupp SI. Dumele O, et al. Adv Mater. 2020 Apr;32(17):e1907247. doi: 10.1002/adma.201907247. Epub 2020 Mar 12. Adv Mater. 2020. PMID: 32162428 Review.
Self-assembly is a bioinspired strategy to craft materials for renewable and clean energy technologies. ...In artificial systems, strategies based on self-assembly using noncovalent interactions offer the possibility to mimic this functional correlation among molecu …
Self-assembly is a bioinspired strategy to craft materials for renewable and clean energy technologies. ...In artificial systems, …
Endometrial cancer: Part I. Basic concept.
Wang PH, Yang ST, Liu CH, Chang WH, Lee FK, Lee WL. Wang PH, et al. Taiwan J Obstet Gynecol. 2022 Nov;61(6):951-959. doi: 10.1016/j.tjog.2022.09.001. Taiwan J Obstet Gynecol. 2022. PMID: 36427997 Free article. Review.
In this part I, we would like to overview the general background knowledge (basic concept) about the cancer of uterine corpus, and discuss the recent transformation to patients-tailored therapy based on modern molecular technology as the optimal strategy to b …
In this part I, we would like to overview the general background knowledge (basic concept) about the cancer of uterine corpus, and di …
Engineered mRNA Delivery Systems for Biomedical Applications.
Wang J, Zhu H, Gan J, Liang G, Li L, Zhao Y. Wang J, et al. Adv Mater. 2024 Apr;36(15):e2308029. doi: 10.1002/adma.202308029. Epub 2024 Feb 8. Adv Mater. 2024. PMID: 37805865 Review.
Messenger RNA (mRNA)-based therapeutic strategies have shown remarkable promise in preventing and treating a staggering range of diseases. ...Herein, a thorough analysis of the optimization strategies used in the structure of mRNA is first provided and delive …
Messenger RNA (mRNA)-based therapeutic strategies have shown remarkable promise in preventing and treating a staggering range of dise …
4,850 results