Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1987 1
1988 2
1989 5
1990 11
1991 13
1992 19
1993 37
1994 57
1995 50
1996 66
1997 64
1998 58
1999 53
2000 51
2001 55
2002 55
2003 61
2004 59
2005 62
2006 67
2007 49
2008 66
2009 78
2010 81
2011 101
2012 100
2013 128
2014 154
2015 184
2016 168
2017 155
2018 138
2019 124
2020 175
2021 164
2022 119
2023 105
2024 40

Text availability

Article attribute

Article type

Publication date

Search Results

2,667 results

Results by year

Filters applied: . Clear all
Page 1
Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion.
Mauvezin C, Neufeld TP. Mauvezin C, et al. Autophagy. 2015;11(8):1437-8. doi: 10.1080/15548627.2015.1066957. Autophagy. 2015. PMID: 26156798 Free PMC article.
Both of these steps are disrupted by the V-ATPase inhibitor bafilomycin A1, but the mechanisms potentially linking them are unclear. ...We identified the ER-calcium ATPase Ca-P60A/dSERCA as a novel target of bafilomycin A1. Autophagosome-lysosome fusio …
Both of these steps are disrupted by the V-ATPase inhibitor bafilomycin A1, but the mechanisms potentially linking them are un …
Bafilomycin A1 inhibits SARS-CoV-2 infection in a human lung xenograft mouse model.
Zhang C, Wei B, Liu Z, Yao W, Li Y, Lu J, Ge C, Yu X, Li D, Zhu Y, Shang C, Jin N, Li X. Zhang C, et al. Virol J. 2023 Jan 31;20(1):18. doi: 10.1186/s12985-023-01971-x. Virol J. 2023. PMID: 36721152 Free PMC article.
Our results showed that the endosomal acidification inhibitor, Bafilomycin A1 (Baf-A1), had an inhibitory effect on the viral RNA synthesis of SARS-CoV-2, and its Beta and Delta variants at the concentration of 500 nM. ...
Our results showed that the endosomal acidification inhibitor, Bafilomycin A1 (Baf-A1), had an inhibitory effect on the viral …
Bafilomycin A1 targets patient-derived CD34(+)CD19(+) leukemia stem cells.
Xu L, Yuan N, Liu H, Fang Y, Ge C, Xu F, An N, Wei W, Li L, Ji L, Zhang X, Meng J, Zhang S, Zhao Y, Chen Z, Chen S, Wu D, Wang J. Xu L, et al. Haematologica. 2020 Jan;105(1):e17-e21. doi: 10.3324/haematol.2018.207258. Epub 2019 May 16. Haematologica. 2020. PMID: 31097633 Free PMC article. No abstract available.
Bafilomycin A1 Accelerates Chronic Refractory Wound Healing in db/db Mice.
Wang F, Zhang C, Dai L, Zhang Y, Wang Y, Hao Y, Ji S, Xu Z, Han N, Chen H, Zhang Q, Nan W. Wang F, et al. Biomed Res Int. 2020 Jul 2;2020:6265701. doi: 10.1155/2020/6265701. eCollection 2020. Biomed Res Int. 2020. PMID: 32714982 Free PMC article.
Numerous studies have reported that autophagy plays an important role in chronic wound healing, and enhancement of autophagic activity impairs cutaneous wound healing. The autophagy inhibitor Bafilomycin A1 (Baf A1) inhibits autophagy by preventing the formation of …
Numerous studies have reported that autophagy plays an important role in chronic wound healing, and enhancement of autophagic activity impai …
Bafilomycin-A1 and ML9 Exert Different Lysosomal Actions to Induce Cell Death.
Shaikh S, Nandy SK, Cantí C, Lavandero S. Shaikh S, et al. Curr Mol Pharmacol. 2019;12(4):261-271. doi: 10.2174/1874467212666190308131250. Curr Mol Pharmacol. 2019. PMID: 30854984
OBJECTIVE: Bafilomycin-A1 and ML9 are lysosomotropic agents, irrespective of cell types. ...We used a molecular docking approach, that predicts a stronger inhibitory activity against V-ATPase-C1 and C2 domains for bafilomycin-A1 in comparison to ML9. C …
OBJECTIVE: Bafilomycin-A1 and ML9 are lysosomotropic agents, irrespective of cell types. ...We used a molecular docking approa …
Bafilomycin A1 and U18666A Efficiently Impair ZIKV Infection.
Sabino C, Basic M, Bender D, Elgner F, Himmelsbach K, Hildt E. Sabino C, et al. Viruses. 2019 Jun 6;11(6):524. doi: 10.3390/v11060524. Viruses. 2019. PMID: 31174294 Free PMC article.
A549 and SH-SY5Y cells were infected with either the African strain (associated with mild symptoms) or the French Polynesia strain (associated with neurological complications). For both strains, the V-ATPase inhibitor, bafilomycin A1, efficiently inhibited ZIKV entr …
A549 and SH-SY5Y cells were infected with either the African strain (associated with mild symptoms) or the French Polynesia strain (associat …
The release and activity of HMGB1 in ferroptosis.
Wen Q, Liu J, Kang R, Zhou B, Tang D. Wen Q, et al. Biochem Biophys Res Commun. 2019 Mar 5;510(2):278-283. doi: 10.1016/j.bbrc.2019.01.090. Epub 2019 Jan 25. Biochem Biophys Res Commun. 2019. PMID: 30686534
In contrast, genetic ablation (using ATG5(-/-) or ATG7(-/-) cells) or pharmacologic inhibition (the administration of bafilomycin A1 or chloroquine) of autophagy was found to block ferroptosis activator-induced HMGB1 release. ...
In contrast, genetic ablation (using ATG5(-/-) or ATG7(-/-) cells) or pharmacologic inhibition (the administration of bafilomycin …
Molecular basis of V-ATPase inhibition by bafilomycin A1.
Wang R, Wang J, Hassan A, Lee CH, Xie XS, Li X. Wang R, et al. Nat Commun. 2021 Mar 19;12(1):1782. doi: 10.1038/s41467-021-22111-5. Nat Commun. 2021. PMID: 33741963 Free PMC article.
The structure reveals six bafilomycin A1 molecules bound to the c-ring. One bafilomycin A1 molecule engages with two c subunits and disrupts the interactions between the c-ring and subunit a, thereby preventing proton translocation. Structural and sequ …
The structure reveals six bafilomycin A1 molecules bound to the c-ring. One bafilomycin A1 molecule engages with …
2,667 results